U.S. flag

An official website of the United States government

Ripk1 receptor interacting serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306886, updated on 9-Dec-2024

Summary

Official Symbol
Ripk1provided by RGD
Official Full Name
receptor interacting serine/threonine kinase 1provided by RGD
Primary source
RGD:1310158
See related
EnsemblRapid:ENSRNOG00000017787 AllianceGenome:RGD:1310158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables death receptor binding activity. Involved in positive regulation of necroptotic process; positive regulation of neuron apoptotic process; and positive regulation of non-canonical NF-kappaB signal transduction. Part of protein-containing complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 117.7), Lung (RPKM 117.5) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ripk1 in Genome Data Viewer
Location:
17p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (31044983..31077167, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30839639..30871824, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (31537580..31569904, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene tubulin, beta 2A class IIa Neighboring gene biphenyl hydrolase like Neighboring gene serpin family B member 6A Neighboring gene N-ribosyldihydronicotinamide:quinone dehydrogenase 2 Neighboring gene uncharacterized LOC102554685

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables JUN kinase kinase kinase activity  
enables death domain binding  
enables death receptor binding PubMed 
enables death receptor binding  
enables identical protein binding  
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein kinase activity  
enables protein kinase activity  
enables protein serine/threonine kinase activity  
enables protein-containing complex binding PubMed 
enables protein-containing complex binding  
enables signaling adaptor activity  
enables ubiquitin protein ligase binding  
Items 1 - 25 of 62
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in T cell apoptotic process  
involved_in T cell apoptotic process  
involved_in amyloid fibril formation  
involved_in amyloid fibril formation  
involved_in apoptotic process  
involved_in apoptotic process  
involved_in cellular response to growth factor stimulus  
involved_in cellular response to hydrogen peroxide  
involved_in cellular response to tumor necrosis factor  
involved_in extrinsic apoptotic signaling pathway  
involved_in intracellular signal transduction  
acts_upstream_of_or_within necroptotic process  
involved_in necroptotic process  
involved_in necroptotic process  
involved_in necroptotic signaling pathway  
involved_in necroptotic signaling pathway  
involved_in necroptotic signaling pathway  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of canonical NF-kappaB signal transduction  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway  
involved_in negative regulation of extrinsic apoptotic signaling pathway  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
involved_in negative regulation of necroptotic process  
involved_in peptidyl-serine autophosphorylation  
involved_in positive regulation of JNK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of NF-kappaB transcription factor activity  
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of execution phase of apoptosis  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway  
involved_in positive regulation of extrinsic apoptotic signaling pathway  
involved_in positive regulation of gene expression  
involved_in positive regulation of inflammatory response  
involved_in positive regulation of interleukin-6-mediated signaling pathway  
involved_in positive regulation of interleukin-8 production  
involved_in positive regulation of macrophage differentiation  
acts_upstream_of positive regulation of miRNA processing  
involved_in positive regulation of necroptotic process PubMed 
involved_in positive regulation of necroptotic process  
involved_in positive regulation of neuron apoptotic process PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of phosphorylation  
involved_in positive regulation of programmed cell death  
involved_in positive regulation of programmed necrotic cell death  
involved_in positive regulation of protein phosphorylation  
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transferase activity  
involved_in positive regulation of tumor necrosis factor production  
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway  
involved_in programmed necrotic cell death  
involved_in protein autophosphorylation  
involved_in protein catabolic process  
involved_in regulation of ATP:ADP antiporter activity  
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process  
involved_in response to oxidative stress  
involved_in response to tumor necrosis factor  
involved_in ripoptosome assembly  
involved_in ripoptosome assembly  
acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process  
Items 1 - 25 of 62
Component Evidence Code Pubs
is_active_in cytoplasm  
part_of death-inducing signaling complex  
located_in mitochondrion  
part_of protein-containing complex PubMed 
part_of protein-containing complex  
part_of receptor complex  
part_of ripoptosome  
part_of ripoptosome  

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 1
Names
RIP
receptor (TNFRSF)-interacting serine-threonine kinase 1
NP_001100820.1
XP_017456015.1
XP_017456017.1
XP_017456018.1
XP_038951624.1
XP_063132480.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107350.1NP_001100820.1  receptor-interacting serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_001100820.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473977
    UniProtKB/TrEMBL
    A6J7H3, D3ZYL0
    Related
    ENSRNOP00000023962.4, ENSRNOT00000023962.7
    Conserved Domains (2) summary
    cd08777
    Location:570655
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23290
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    31044983..31077167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600528.3XP_017456017.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A6J7H3, D3ZYL0
    Conserved Domains (2) summary
    cd08777
    Location:570655
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23290
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017600529.2XP_017456018.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A6J7H3, D3ZYL0
    Conserved Domains (2) summary
    cd08777
    Location:570655
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23290
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017600526.2XP_017456015.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A6J7H3, D3ZYL0
    Conserved Domains (2) summary
    cd08777
    Location:570655
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:23290
    PKc_like; Protein Kinases, catalytic domain
  4. XM_063276410.1XP_063132480.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A6J7H3, D3ZYL0
  5. XM_039095696.1XP_038951624.1  receptor-interacting serine/threonine-protein kinase 1 isoform X2

    Conserved Domains (2) summary
    cd08777
    Location:378463
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cl21453
    Location:198
    PKc_like; Protein Kinases, catalytic domain
External link. Please review our privacy policy.