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TBCC tubulin folding cofactor C [ Homo sapiens (human) ]

Gene ID: 6903, updated on 10-Dec-2024

Summary

Official Symbol
TBCCprovided by HGNC
Official Full Name
tubulin folding cofactor Cprovided by HGNC
Primary source
HGNC:HGNC:11580
See related
Ensembl:ENSG00000124659 MIM:602971; AllianceGenome:HGNC:11580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFC
Summary
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See TBCC in Genome Data Viewer
Location:
6p21.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42744498..42746103, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42573235..42574840, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42712236..42713841, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak5809 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42677933-42678518 Neighboring gene peripherin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24565 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42713934-42714897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24569 Neighboring gene putative uncharacterized protein encoded by LINC00269 Neighboring gene BICRA like chromatin remodeling complex associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24570 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42750599-42751288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42751289-42751978 Neighboring gene uncharacterized LOC401261

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activity PubMed 
enables protein binding PubMed 
enables protein-folding chaperone binding PubMed 
enables tubulin binding  
Process Evidence Code Pubs
involved_in post-chaperonin tubulin folding pathway PubMed 
involved_in protein folding  
involved_in protein folding PubMed 
involved_in tubulin complex assembly  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoskeleton PubMed 
located_in cytosol  
located_in microtubule PubMed 
located_in photoreceptor connecting cilium PubMed 

General protein information

Preferred Names
tubulin-specific chaperone C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003192.3NP_003183.2  tubulin-specific chaperone C

    Status: REVIEWED

    Source sequence(s)
    AL353716
    Consensus CDS
    CCDS4872.1
    UniProtKB/Swiss-Prot
    Q15814, Q53Y43, Q5T787
    Related
    ENSP00000361967.1, ENST00000372876.2
    Conserved Domains (2) summary
    pfam07986
    Location:204321
    TBCC; Tubulin binding cofactor C
    pfam16752
    Location:29135
    TBCC_N; Tubulin-specific chaperone C N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    42744498..42746103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42573235..42574840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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