U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Slc46a1 solute carrier family 46, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 52466, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc46a1provided by MGI
    Official Full Name
    solute carrier family 46, member 1provided by MGI
    Primary source
    MGI:MGI:1098733
    See related
    Ensembl:ENSMUSG00000020829 AllianceGenome:MGI:1098733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HCP1; Pcft; D11Ertd18e; 1110002C08Rik
    Summary
    Enables folic acid:proton symporter activity; heme transmembrane transporter activity; and methotrexate transmembrane transporter activity. Involved in folate import across plasma membrane and heme transport. Located in apical plasma membrane and cytoplasm. Is active in basolateral plasma membrane. Is expressed in adrenal gland; early conceptus; gonad; metanephros; and spinal cord. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 274.9), small intestine adult (RPKM 108.1) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc46a1 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78356527..78362771)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78465701..78471945)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30367 Neighboring gene forkhead box N1 Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Neighboring gene sterile alpha and HEAT/Armadillo motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10695 Neighboring gene SEBOX homeobox Neighboring gene vitronectin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • FLJ00234

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in folate import across plasma membrane PubMed 
    involved_in folate import across plasma membrane  
    involved_in folate transmembrane transport  
    involved_in folic acid transport  
    involved_in folic acid transport  
    involved_in heme transport PubMed 
    involved_in methotrexate transport  
    involved_in proton transmembrane transport  
    involved_in proton transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    is_active_in basolateral plasma membrane PubMed 
    is_active_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in brush border membrane  
    located_in brush border membrane  
    located_in cytoplasm PubMed 
    located_in endosome  
    located_in endosome membrane  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    proton-coupled folate transporter
    Names
    PCFT/HCP1
    heme carrier protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026740.2NP_081016.2  proton-coupled folate transporter

      See identical proteins and their annotated locations for NP_081016.2

      Status: VALIDATED

      Source sequence(s)
      AK003278, AL591177, BE984585, CX219335
      Consensus CDS
      CCDS25104.1
      UniProtKB/Swiss-Prot
      Q571I8, Q5SYG0, Q6PEM8, Q8R1H7, Q9D1P1
      Related
      ENSMUSP00000001126.4, ENSMUST00000001126.4
      Conserved Domains (2) summary
      cd06174
      Location:73443
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:94407
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78356527..78362771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.