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MARK4 microtubule affinity regulating kinase 4 [ Homo sapiens (human) ]

Gene ID: 57787, updated on 10-Dec-2024

Summary

Official Symbol
MARK4provided by HGNC
Official Full Name
microtubule affinity regulating kinase 4provided by HGNC
Primary source
HGNC:HGNC:13538
See related
Ensembl:ENSG00000007047 MIM:606495; AllianceGenome:HGNC:13538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L
Summary
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in testis (RPKM 14.0), brain (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

See MARK4 in Genome Data Viewer
Location:
19q13.32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45251271..45305284)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48077944..48131959)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45754529..45808542)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14789 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45682829-45683329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45683755-45684256 Neighboring gene Sharpr-MPRA regulatory region 2997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10758 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 3 Neighboring gene Sharpr-MPRA regulatory region 12921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45719170-45719704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45720327-45721022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45721023-45721716 Neighboring gene exocyst complex component 3 like 2 Neighboring gene exocyst complex component 3 like 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45748359-45749355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45755437-45755993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45767676-45768261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45768262-45768846 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:45794892-45795094 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:45811788-45811945 Neighboring gene heart enhancer 22 Neighboring gene creatine kinase, M-type Neighboring gene ribosomal protein S16 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ12177, FLJ90097, KIAA1860

Gene Ontology Provided by GOA

Items 1 - 25 of 35
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables cytoskeletal anchor activity PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables gamma-tubulin binding PubMed 
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables microtubule binding PubMed 
enables protein binding PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables ribosomal protein S6 kinase activity  
enables tau protein binding PubMed 
enables tau-protein kinase activity  
enables tau-protein kinase activity PubMed 
enables tau-protein kinase activity PubMed 
enables tau-protein kinase activity PubMed 
enables ubiquitin binding PubMed 
Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in cell division  
involved_in chromatin remodeling  
involved_in cilium organization PubMed 
involved_in intracellular signal transduction  
involved_in microtubule bundle formation PubMed 
NOT involved_in microtubule cytoskeleton organization PubMed 
involved_in microtubule cytoskeleton organization PubMed 
involved_in nervous system development PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly PubMed 
acts_upstream_of_or_within positive regulation of cell cycle PubMed 
involved_in positive regulation of cilium assembly PubMed 
involved_in positive regulation of programmed cell death  
involved_in positive regulation of protein localization to centrosome PubMed 
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of centrosome cycle PubMed 
Component Evidence Code Pubs
located_in centrosome PubMed 
located_in ciliary basal body PubMed 
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in dendrite PubMed 
part_of gamma-tubulin complex PubMed 
located_in microtubule cytoskeleton PubMed 
is_active_in microtubule organizing center PubMed 
located_in microtubule organizing center PubMed 
located_in midbody PubMed 
located_in neuron projection PubMed 

General protein information

Preferred Names
MAP/microtubule affinity-regulating kinase 4
Names
MAP/microtubule affinity-regulating kinase like 1
MARK4 serine/threonine protein kinase
epididymis secretory sperm binding protein
NP_001186796.1
NP_113605.2
XP_006723370.1
XP_054177554.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199867.2NP_001186796.1  MAP/microtubule affinity-regulating kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_001186796.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC005581, AC005781, AC006126
    Consensus CDS
    CCDS56097.1
    UniProtKB/Swiss-Prot
    Q8NG37, Q96JG7, Q96L34, Q96SQ2, Q9BYD8
    Related
    ENSP00000262891.3, ENST00000262891.9
    Conserved Domains (4) summary
    cd12197
    Location:654752
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:59310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. NM_031417.4NP_113605.2  MAP/microtubule affinity-regulating kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_113605.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005581, AC005781, AC006126
    Consensus CDS
    CCDS12658.1
    UniProtKB/Swiss-Prot
    Q96L34
    Related
    ENSP00000300843.3, ENST00000300843.8
    Conserved Domains (3) summary
    smart00220
    Location:59310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    45251271..45305284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723307.5XP_006723370.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

    Conserved Domains (4) summary
    cd12197
    Location:587685
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:12243
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:261303
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:18243
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48077944..48131959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321579.1XP_054177554.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

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