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    Bok BCL2 family apoptosis regulator BOK [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29884, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bokprovided by RGD
    Official Full Name
    BCL2 family apoptosis regulator BOKprovided by RGD
    Primary source
    RGD:70984
    See related
    EnsemblRapid:ENSRNOG00000018214 AllianceGenome:RGD:70984
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bok-BH3
    Summary
    Enables BH domain binding activity and protein heterodimerization activity. Involved in several processes, including male gonad development; oligodendrocyte differentiation; and positive regulation of apoptotic process. Predicted to be located in several cellular components, including bounding membrane of organelle; mitochondrial inner membrane; and trans-Golgi network membrane. Predicted to be active in mitochondrial outer membrane. Biomarker of hydrocephalus. Orthologous to human BOK (BCL2 family apoptosis regulator BOK). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 146.6), Testes (RPKM 133.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Bok in Genome Data Viewer
    Location:
    9q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101670729..101681834)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94223493..94234476)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100829593..100840498)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene 5S ribosomal RNA Neighboring gene serine/threonine kinase 25 Neighboring gene THAP domain containing 4 Neighboring gene autophagy related 4B, cysteine peptidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BH domain binding PubMed 
    enables channel activity  
    enables protein binding PubMed 
    enables protein dimerization activity PubMed 
    NOT enables protein heterodimerization activity PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein-containing complex binding PubMed 
    enables signaling receptor binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in apoptotic process PubMed 
    involved_in apoptotic process PubMed 
    involved_in apoptotic process  
    involved_in cellular component disassembly involved in execution phase of apoptosis  
    involved_in cellular component disassembly involved in execution phase of apoptosis  
    involved_in extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage  
    involved_in male gonad development PubMed 
    involved_in negative regulation of mitochondrial depolarization  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    involved_in negative regulation of necroptotic process  
    involved_in negative regulation of neuron apoptotic process  
    acts_upstream_of_or_within neuron apoptotic process  
    involved_in oligodendrocyte differentiation PubMed 
    involved_in positive regulation of PERK-mediated unfolded protein response  
    involved_in positive regulation of PERK-mediated unfolded protein response  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    involved_in protein complex oligomerization  
    involved_in protein complex oligomerization  
    involved_in regulation of autophagy  
    involved_in regulation of chorionic trophoblast cell proliferation  
    involved_in regulation of chorionic trophoblast cell proliferation  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of granulosa cell apoptotic process  
    involved_in regulation of granulosa cell apoptotic process  
    involved_in release of cytochrome c from mitochondria  
    involved_in release of cytochrome c from mitochondria  
    involved_in response to cisplatin PubMed 
    involved_in transmembrane transport  
    Items 1 - 25 of 42
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cis-Golgi network membrane  
    located_in cis-Golgi network membrane  
    located_in cytoplasm  
    located_in early endosome membrane  
    located_in early endosome membrane  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial membrane  
    located_in mitochondrial membrane  
    is_active_in mitochondrial outer membrane  
    located_in mitochondrion  
    located_in nuclear outer membrane  
    located_in nucleus  
    located_in nucleus  
    located_in recycling endosome membrane  
    located_in recycling endosome membrane  
    located_in trans-Golgi network membrane  
    located_in trans-Golgi network membrane  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    bcl-2-related ovarian killer protein
    Names
    BCL2-related ovarian killer
    BOK, BCL2 family apoptosis regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017312.2NP_059008.1  bcl-2-related ovarian killer protein

      See identical proteins and their annotated locations for NP_059008.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078871
      UniProtKB/Swiss-Prot
      O88857, Q792S6
      UniProtKB/TrEMBL
      A6JR24
      Related
      ENSRNOP00000024693.3, ENSRNOT00000024695.8
      Conserved Domains (1) summary
      cd06845
      Location:37178
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101670729..101681834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083130.2XP_038939058.1  bcl-2-related ovarian killer protein isoform X1

      UniProtKB/TrEMBL
      A6JR25
      Related
      ENSRNOP00000024526.2, ENSRNOT00000024526.6
      Conserved Domains (1) summary
      smart00337
      Location:32129
      BCL; BCL (B-Cell lymphoma); contains BH1, BH2 regions
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