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HOXB9 homeobox B9 [ Homo sapiens (human) ]

Gene ID: 3219, updated on 10-Dec-2024

Summary

Official Symbol
HOXB9provided by HGNC
Official Full Name
homeobox B9provided by HGNC
Primary source
HGNC:HGNC:5120
See related
Ensembl:ENSG00000170689 MIM:142964; AllianceGenome:HGNC:5120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX2; HOX2E; HOX-2.5
Summary
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 12.6), kidney (RPKM 7.0) and 3 other tissues See more
Orthologs
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Genomic context

See HOXB9 in Genome Data Viewer
Location:
17q21.32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48621156..48626358, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49484752..49489954, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46698518..46703720, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46684881-46685426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46687251-46688071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46688072-46688891 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46688892-46689712 Neighboring gene homeobox B7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46694872-46695395 Neighboring gene homeobox B8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46702573-46703250 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:46704661-46704816 Neighboring gene HOXB cluster antisense RNA 4 Neighboring gene microRNA 196a-1 Neighboring gene long intergenic non-protein coding RNA 3057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46718588-46719586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46719587-46720583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46723751-46724419 Neighboring gene long intergenic non-protein coding RNA 2086

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA-templated transcription  
involved_in anterior/posterior pattern specification  
involved_in cell chemotaxis PubMed 
involved_in embryonic skeletal system morphogenesis  
involved_in mammary gland development  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in proximal/distal pattern formation  
involved_in regulation of transcription by RNA polymerase II  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex  
located_in chromatin  
located_in nucleoplasm  
is_active_in nucleus  

General protein information

Preferred Names
homeobox protein Hox-B9
Names
homeo box 2E
homeo box B9
homeobox protein Hox-2.5
homeobox protein Hox-2E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024017.5NP_076922.1  homeobox protein Hox-B9

    See identical proteins and their annotated locations for NP_076922.1

    Status: REVIEWED

    Source sequence(s)
    AK056123, AK056414, BC015565, BX114117, CA426693, DA696753
    Consensus CDS
    CCDS11534.1
    UniProtKB/Swiss-Prot
    B2RDB7, P17482, Q9H1I1
    Related
    ENSP00000309439.5, ENST00000311177.7
    Conserved Domains (2) summary
    pfam00046
    Location:188241
    Homeobox; Homeobox domain
    pfam04617
    Location:1172
    Hox9_act; Hox9 activation region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    48621156..48626358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    49484752..49489954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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