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    TIGD7 tigger transposable element derived 7 [ Homo sapiens (human) ]

    Gene ID: 91151, updated on 10-Dec-2024

    Summary

    Official Symbol
    TIGD7provided by HGNC
    Official Full Name
    tigger transposable element derived 7provided by HGNC
    Primary source
    HGNC:HGNC:18331
    See related
    Ensembl:ENSG00000140993 MIM:612969; AllianceGenome:HGNC:18331
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Sancho
    Summary
    The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 5.6), ovary (RPKM 4.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TIGD7 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3298808..3305430, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3325858..3332480, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3348808..3355430, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:3293322-3294521 Neighboring gene MEFV innate immunity regulator, pyrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10318 Neighboring gene long intergenic non-protein coding RNA 921 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3332464-3332969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7131 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3333980-3334483 Neighboring gene zinc finger protein 263 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3354991-3355520 Neighboring gene zinc finger protein 75A Neighboring gene RPL7L1 pseudogene 19 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:3414288-3415487 Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-CO2 pseudogene 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Clone Names

    • FLJ98002, FLJ99447

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    tigger transposable element-derived protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033208.4NP_149985.2  tigger transposable element-derived protein 7

      See identical proteins and their annotated locations for NP_149985.2

      Status: REVIEWED

      Source sequence(s)
      AC004232, AI925903, AK308054, BX463753, DC351858
      Consensus CDS
      CCDS10500.1
      UniProtKB/Swiss-Prot
      Q6NT04, Q9BXZ0
      Related
      ENSP00000380071.1, ENST00000396862.2
      Conserved Domains (3) summary
      pfam03221
      Location:77135
      HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
      cl21459
      Location:455
      HTH; Helix-turn-helix domains
      cl21549
      Location:207399
      rve; Integrase core domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3298808..3305430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3325858..3332480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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