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Hinfp histone H4 transcription factor [ Mus musculus (house mouse) ]

Gene ID: 102423, updated on 9-Dec-2024

Summary

Official Symbol
Hinfpprovided by MGI
Official Full Name
histone H4 transcription factorprovided by MGI
Primary source
MGI:MGI:2429620
See related
Ensembl:ENSMUSG00000032119 AllianceGenome:MGI:2429620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mizf; HiNF-P
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in DNA-templated transcription; in utero embryonic development; and regulation of gene expression. Predicted to be located in Cajal body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human HINFP (histone H4 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.6), CNS E14 (RPKM 5.0) and 28 other tissues See more
Orthologs
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Genomic context

See Hinfp in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44201509..44217003, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44292438..44305716, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NLR family member X1 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44113766-44114058 Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene STARR-seq mESC enhancer starr_23963 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene H2A.X variant histone

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Clone Names

  • DKFZp434F162

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding  
enables DNA binding  
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
enables chromatin binding PubMed 
enables enzyme binding  
enables enzyme binding  
enables histone binding  
enables histone binding  
enables metal ion binding  
enables transcription cis-regulatory region binding  
enables transcription cis-regulatory region binding  
Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling  
involved_in DNA damage checkpoint signaling  
involved_in DNA repair  
involved_in DNA repair  
involved_in DNA-templated transcription PubMed 
involved_in G1/S transition of mitotic cell cycle  
involved_in G1/S transition of mitotic cell cycle  
involved_in cell cycle G1/S phase transition  
involved_in cell cycle G1/S phase transition  
involved_in establishment of protein localization  
involved_in establishment of protein localization  
involved_in in utero embryonic development PubMed 
involved_in myoblast differentiation  
involved_in myoblast differentiation  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of gene expression  
involved_in negative regulation of gene expression  
involved_in negative regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of gene expression  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of DNA-templated transcription  
involved_in regulation of DNA-templated transcription  
involved_in regulation of transcription by RNA polymerase II  
Items 1 - 25 of 29
Component Evidence Code Pubs
located_in Cajal body  
located_in Cajal body  
NOT located_in nucleolus  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
histone H4 transcription factor
Names
MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
MBD2-interacting zinc finger protein
histone nuclear factor P
methyl-CpG-binding protein 2-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405064.1NP_001391993.1  histone H4 transcription factor

    Status: VALIDATED

    Source sequence(s)
    AC124577
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    UniProtKB/TrEMBL
    Q4FK13
  2. NM_001405065.1NP_001391994.1  histone H4 transcription factor

    Status: VALIDATED

    Source sequence(s)
    AC124577
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    UniProtKB/TrEMBL
    Q4FK13
    Related
    ENSMUSP00000034629.6, ENSMUST00000034629.6
  3. NM_001405066.1NP_001391995.1  histone H4 transcription factor

    Status: VALIDATED

    Source sequence(s)
    AC124577
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    UniProtKB/TrEMBL
    Q4FK13
  4. NM_172162.4NP_751894.2  histone H4 transcription factor

    See identical proteins and their annotated locations for NP_751894.2

    Status: VALIDATED

    Source sequence(s)
    AC124577
    Consensus CDS
    CCDS23102.1
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    UniProtKB/TrEMBL
    Q4FK13
    Related
    ENSMUSP00000149879.2, ENSMUST00000216508.2
    Conserved Domains (2) summary
    COG5048
    Location:224377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:282302
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44201509..44217003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242379.3XP_011240681.1  histone H4 transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011240681.1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011242378.4XP_011240680.1  histone H4 transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011240680.1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_006509897.5XP_006509960.1  histone H4 transcription factor isoform X3

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:231384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289309
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_030243934.2XP_030099794.1  histone H4 transcription factor isoform X2

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_011242376.4XP_011240678.1  histone H4 transcription factor isoform X1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:240393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:298318
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_036154502.1XP_036010395.1  histone H4 transcription factor isoform X2

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_030243935.2XP_030099795.1  histone H4 transcription factor isoform X4

    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:224377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:282302
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_030243933.2XP_030099793.1  histone H4 transcription factor isoform X2

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_011242377.4XP_011240679.1  histone H4 transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011240679.1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291311
    ZF_C2H2; C2H2 Zn finger [structural motif]
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