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Tlx2 T cell leukemia, homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 21909, updated on 9-Dec-2024

Summary

Official Symbol
Tlx2provided by MGI
Official Full Name
T cell leukemia, homeobox 2provided by MGI
Primary source
MGI:MGI:1350935
See related
Ensembl:ENSMUSG00000068327 AllianceGenome:MGI:1350935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Enx; NCX; Ncx1; Tlx1l1; Tlx1l2; Hox11l1; Hox11L.1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within enteric nervous system development; mesoderm formation; and negative regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; primitive streak; and urinary system. Used to study intestinal pseudo-obstruction. Orthologous to human TLX2 (T cell leukemia homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in adrenal adult (RPKM 24.6), duodenum adult (RPKM 3.7) and 4 other tissues See more
Orthologs
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Genomic context

See Tlx2 in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83045306..83047206, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83068325..83070225, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9275 Neighboring gene HtrA serine peptidase 2 Neighboring gene ancient ubiquitous protein 1 Neighboring gene DEAQ RNA-dependent ATPase Neighboring gene polycomb group ring finger 1 Neighboring gene ladybird homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm PubMed 
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus PubMed 

General protein information

Preferred Names
T-cell leukemia homeobox protein 2
Names
PMUR10F
enteric neuron homeobox protein
homeo box 11-like 1
homeobox TLX-2
homeobox protein Hox-11L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009392.2NP_033418.1  T-cell leukemia homeobox protein 2

    See identical proteins and their annotated locations for NP_033418.1

    Status: VALIDATED

    Source sequence(s)
    AC134899, AK013072, M75953
    Consensus CDS
    CCDS20269.1
    UniProtKB/Swiss-Prot
    B2RR62, Q61663
    Related
    ENSMUSP00000087069.4, ENSMUST00000089641.6
    Conserved Domains (1) summary
    pfam00046
    Location:160213
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83045306..83047206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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