U.S. flag

An official website of the United States government

Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11933, updated on 9-Dec-2024

Summary

Official Symbol
Atp1b3provided by MGI
Official Full Name
ATPase, Na+/K+ transporting, beta 3 polypeptideprovided by MGI
Primary source
MGI:MGI:107788
See related
Ensembl:ENSMUSG00000032412 AllianceGenome:MGI:107788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPB-3
Summary
Predicted to enable several functions, including ATPase activator activity; ATPase binding activity; and P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in several processes, including intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and positive regulation of cation transmembrane transport. Located in cytoplasm. Is expressed in several structures, including early conceptus; heart; hemolymphoid system; nervous system; and sensory organ. Orthologous to human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis adult (RPKM 23.7), cerebellum adult (RPKM 12.0) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atp1b3 in Genome Data Viewer
Location:
9 E3.3; 9 50.31 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96214708..96246368, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96332655..96364431, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8308 Neighboring gene glycerol kinase 5 Neighboring gene transcription factor Dp 2 Neighboring gene STARR-seq mESC enhancer starr_24949 Neighboring gene predicted gene, 39408 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96299921-96300222 Neighboring gene predicted gene, 39409 Neighboring gene predicted gene, 40550 Neighboring gene STARR-seq mESC enhancer starr_24955 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:96338415-96338742 Neighboring gene cDNA sequence BC043934

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity  
enables ATPase activator activity  
enables ATPase activator activity  
enables ATPase binding  
enables ATPase binding  
enables P-type sodium:potassium-exchanging transporter activity  
enables protein binding PubMed 
enables protein-macromolecule adaptor activity  
enables protein-macromolecule adaptor activity  
Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in membrane repolarization  
involved_in membrane repolarization  
involved_in metal ion transport  
involved_in positive regulation of ATP-dependent activity  
involved_in positive regulation of potassium ion import across plasma membrane  
involved_in positive regulation of potassium ion import across plasma membrane  
involved_in positive regulation of potassium ion transmembrane transporter activity  
involved_in positive regulation of sodium ion export across plasma membrane  
involved_in positive regulation of sodium ion export across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion transmembrane transport  
involved_in potassium ion transport  
involved_in protein localization to plasma membrane  
involved_in protein localization to plasma membrane  
involved_in protein stabilization  
involved_in protein stabilization  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion transmembrane transport  
involved_in sodium ion transport  
Items 1 - 25 of 29
Component Evidence Code Pubs
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in caveola  
located_in cytoplasm PubMed 
located_in melanosome  
located_in plasma membrane  
part_of sodium:potassium-exchanging ATPase complex  
part_of sodium:potassium-exchanging ATPase complex  
part_of sodium:potassium-exchanging ATPase complex  
located_in sperm flagellum  
located_in sperm flagellum  

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-3
Names
ATPase, Na+/K+ beta 3 polypeptide
Na K-ATPase beta-3 subunit
sodium/potassium-dependent ATPase subunit beta-3
NP_001344141.1
NP_001344142.1
NP_001398556.1
NP_001398557.1
NP_031528.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357212.2NP_001344141.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC117248
    Conserved Domains (1) summary
    cl08255
    Location:1242
    Na_K-ATPase; Sodium / potassium ATPase beta chain
  2. NM_001357213.2NP_001344142.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC117248
    Conserved Domains (1) summary
    cl08255
    Location:1221
    Na_K-ATPase; Sodium / potassium ATPase beta chain
  3. NM_001411627.1NP_001398556.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117248
  4. NM_001411628.1NP_001398557.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117248
  5. NM_007502.6NP_031528.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 1

    See identical proteins and their annotated locations for NP_031528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC117248
    Consensus CDS
    CCDS23414.1
    UniProtKB/Swiss-Prot
    P97370
    UniProtKB/TrEMBL
    Q544Q7
    Related
    ENSMUSP00000034983.6, ENSMUST00000034983.7
    Conserved Domains (1) summary
    cl08255
    Location:1278
    Na_K-ATPase; Sodium / potassium ATPase beta chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    96214708..96246368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.