U.S. flag

An official website of the United States government

Rfx6 regulatory factor X, 6 [ Mus musculus (house mouse) ]

Gene ID: 320995, updated on 9-Dec-2024

Summary

Official Symbol
Rfx6provided by MGI
Official Full Name
regulatory factor X, 6provided by MGI
Primary source
MGI:MGI:2445208
See related
Ensembl:ENSMUSG00000019900 AllianceGenome:MGI:2445208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rfxdc1; 4930572O07Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in enteroendocrine cell differentiation; glucose homeostasis; and regulation of insulin secretion. Located in nucleus. Is expressed in several structures, including gut; limb; liver; male reproductive gland or organ; and sensory organ. Orthologous to human RFX6 (regulatory factor X6). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rfx6 in Genome Data Viewer
Location:
10 B3; 10 25.74 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (51553856..51606525)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (51677760..51730429)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 162, member B Neighboring gene STARR-seq mESC enhancer starr_26663 Neighboring gene G protein-coupled receptor, family C, group 6, member A Neighboring gene Sumo1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26664 Neighboring gene predicted gene, 23906

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in endocrine pancreas development  
involved_in glucose homeostasis PubMed 
involved_in glucose homeostasis  
involved_in pancreatic A cell differentiation PubMed 
involved_in pancreatic D cell differentiation PubMed 
involved_in pancreatic epsilon cell differentiation PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of insulin secretion PubMed 
involved_in regulation of insulin secretion  
involved_in regulation of transcription by RNA polymerase II  
involved_in type B pancreatic cell differentiation PubMed 
Component Evidence Code Pubs
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
DNA-binding protein RFX6
Names
regulatory factor X domain containing 1
regulatory factor X domain-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159389.1NP_001152861.1  DNA-binding protein RFX6 isoform 1

    See identical proteins and their annotated locations for NP_001152861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC153527
    Consensus CDS
    CCDS48558.1
    UniProtKB/Swiss-Prot
    Q8C7R7, Q8CDN5
    UniProtKB/TrEMBL
    D5FLC2
    Related
    ENSMUSP00000116057.2, ENSMUST00000122922.10
    Conserved Domains (1) summary
    pfam02257
    Location:123196
    RFX_DNA_binding; RFX DNA-binding domain
  2. NM_177306.3NP_796280.1  DNA-binding protein RFX6 isoform 2

    See identical proteins and their annotated locations for NP_796280.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK029809
    Consensus CDS
    CCDS23835.1
    UniProtKB/Swiss-Prot
    Q8C7R7
    Related
    ENSMUSP00000057384.5, ENSMUST00000050455.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    51553856..51606525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.