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Igf1 insulin-like growth factor 1 [ Mus musculus (house mouse) ]

Gene ID: 16000, updated on 9-Dec-2024

Summary

Official Symbol
Igf1provided by MGI
Official Full Name
insulin-like growth factor 1provided by MGI
Primary source
MGI:MGI:96432
See related
Ensembl:ENSMUSG00000020053 AllianceGenome:MGI:96432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igf-1; Igf-I; C730016P09Rik
Summary
This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. This gene is predominantly expressed in the liver and the encoded protein undergoes proteolytic processing to generate a disulfide-linked mature polypeptide. Transgenic disruption of this gene in mice results in reduced postnatal survival and severe growth retardation. Mice lacking the encoded protein exhibit generalized organ hypoplasia including underdevelopment of the central nervous system and developmental defects in bone, muscle and reproductive systems. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Expression
Biased expression in liver adult (RPKM 36.1), subcutaneous fat pad adult (RPKM 12.7) and 8 other tissues See more
Orthologs
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Genomic context

See Igf1 in Genome Data Viewer
Location:
10 C1; 10 43.7 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (87694127..87772909)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (87858265..87937047)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30073 Neighboring gene nuclear encoded tRNA lysine 21 (anticodon TTT) Neighboring gene insulin-like growth factor 1, opposite strand Neighboring gene VISTA enhancer mm694 Neighboring gene STARR-seq mESC enhancer starr_27486 Neighboring gene STARR-seq mESC enhancer starr_27487 Neighboring gene thymidylate synthase, pseudogene Neighboring gene STARR-seq mESC enhancer starr_27490 Neighboring gene STARR-seq mESC enhancer starr_27491 Neighboring gene predicted gene, 30233

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity  
enables hormone activity  
enables hormone activity  
enables hormone activity  
enables insulin receptor binding PubMed 
enables insulin receptor binding  
enables insulin-like growth factor receptor binding  
enables insulin-like growth factor receptor binding PubMed 
enables insulin-like growth factor receptor binding  
enables integrin binding  
enables protein binding PubMed 
enables protein serine/threonine kinase activator activity  
enables receptor ligand activity PubMed 
enables receptor ligand activity PubMed 
enables receptor ligand activity PubMed 
enables steroid binding  
enables transmembrane receptor protein tyrosine kinase activator activity PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity PubMed 
Items 1 - 25 of 147
Process Evidence Code Pubs
involved_in activation of protein kinase B activity  
acts_upstream_of androgen receptor signaling pathway PubMed 
acts_upstream_of_or_within blood vessel remodeling PubMed 
acts_upstream_of_or_within blood vessel remodeling PubMed 
involved_in bone mineralization involved in bone maturation  
acts_upstream_of_or_within branching morphogenesis of an epithelial tube PubMed 
acts_upstream_of_or_within cell activation PubMed 
acts_upstream_of_or_within cell development PubMed 
involved_in cell population proliferation  
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of cell population proliferation PubMed 
involved_in cell population proliferation  
involved_in cellular response to amyloid-beta  
acts_upstream_of_or_within cellular response to glucose stimulus PubMed 
acts_upstream_of_or_within cellular response to insulin-like growth factor stimulus PubMed 
acts_upstream_of cerebellar granule cell precursor proliferation PubMed 
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process PubMed 
involved_in circadian rhythm PubMed 
involved_in detection of mechanical stimulus involved in sensory perception  
acts_upstream_of_or_within exocrine pancreas development PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand PubMed 
acts_upstream_of_or_within glial cell differentiation PubMed 
acts_upstream_of_or_within inner ear development PubMed 
involved_in insulin-like growth factor receptor signaling pathway  
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway PubMed 
involved_in insulin-like growth factor receptor signaling pathway PubMed 
involved_in insulin-like growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within lung alveolus development PubMed 
acts_upstream_of_or_within lung alveolus development PubMed 
acts_upstream_of_or_within lung development PubMed 
acts_upstream_of_or_within lung lobe morphogenesis PubMed 
acts_upstream_of_or_within lung lobe morphogenesis PubMed 
acts_upstream_of_or_within lung vasculature development PubMed 
acts_upstream_of_or_within lung vasculature development PubMed 
acts_upstream_of_or_within mammary gland development PubMed 
involved_in memory  
acts_upstream_of_or_within multicellular organism growth PubMed 
involved_in muscle hypertrophy  
involved_in myoblast differentiation  
involved_in myoblast proliferation  
involved_in myotube cell development  
acts_upstream_of_or_within myotube differentiation PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade PubMed 
involved_in negative regulation of amyloid-beta formation  
acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway PubMed 
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
involved_in negative regulation of cholangiocyte apoptotic process  
involved_in negative regulation of extrinsic apoptotic signaling pathway  
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of gene expression  
involved_in negative regulation of immune system process  
involved_in negative regulation of interleukin-1 beta production  
involved_in negative regulation of muscle cell apoptotic process  
involved_in negative regulation of neuroinflammatory response  
involved_in negative regulation of oligodendrocyte apoptotic process  
involved_in negative regulation of oocyte development  
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria PubMed 
involved_in negative regulation of smooth muscle cell apoptotic process  
involved_in negative regulation of smooth muscle cell apoptotic process  
involved_in negative regulation of tumor necrosis factor production  
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process  
acts_upstream_of_or_within nervous system development PubMed 
involved_in osteoblast differentiation PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of D-glucose import  
involved_in positive regulation of D-glucose import  
involved_in positive regulation of DNA binding  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of Ras protein signal transduction  
involved_in positive regulation of activated T cell proliferation  
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of calcineurin-NFAT signaling cascade  
involved_in positive regulation of cardiac muscle hypertrophy  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell growth involved in cardiac muscle cell development  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation PubMed 
involved_in positive regulation of epithelial cell proliferation  
involved_in positive regulation of fat cell differentiation  
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of gene expression  
involved_in positive regulation of glial cell proliferation  
involved_in positive regulation of glycogen biosynthetic process  
involved_in positive regulation of glycogen biosynthetic process  
involved_in positive regulation of glycolytic process  
involved_in positive regulation of glycoprotein biosynthetic process  
involved_in positive regulation of insulin-like growth factor receptor signaling pathway  
involved_in positive regulation of mitotic nuclear division  
involved_in positive regulation of myelination PubMed 
acts_upstream_of_or_within positive regulation of myoblast proliferation PubMed 
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of protein secretion  
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of steroid hormone biosynthetic process  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription regulatory region DNA binding  
involved_in positive regulation of trophectodermal cell proliferation  
acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein  
involved_in positive regulation of vascular associated smooth muscle cell proliferation  
involved_in positive regulation of vascular endothelial cell proliferation  
involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis PubMed 
acts_upstream_of_or_within prostate gland epithelium morphogenesis PubMed 
acts_upstream_of_or_within prostate gland growth PubMed 
acts_upstream_of_or_within prostate gland growth PubMed 
acts_upstream_of_or_within prostate gland stromal morphogenesis PubMed 
involved_in protein stabilization  
involved_in proteoglycan biosynthetic process  
involved_in regulation of calcium ion transport  
involved_in regulation of cell population proliferation  
acts_upstream_of_or_within regulation of establishment or maintenance of cell polarity PubMed 
involved_in regulation of gene expression  
acts_upstream_of_or_within regulation of intracellular steroid hormone receptor signaling pathway  
acts_upstream_of_or_within regulation of nitric oxide biosynthetic process PubMed 
acts_upstream_of_or_within regulation of protein metabolic process PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation PubMed 
involved_in regulation of translation  
involved_in response to ethanol  
involved_in response to heat  
involved_in retinal cell apoptotic process  
involved_in sensory perception of smell PubMed 
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  
acts_upstream_of type B pancreatic cell proliferation PubMed 
acts_upstream_of_or_within type I pneumocyte differentiation PubMed 
acts_upstream_of_or_within type II pneumocyte differentiation PubMed 
involved_in wound healing  
Items 1 - 25 of 147
Component Evidence Code Pubs
part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
located_in exocytic vesicle PubMed 
located_in extracellular space PubMed 
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
part_of insulin-like growth factor ternary complex  
part_of insulin-like growth factor ternary complex  
part_of insulin-like growth factor ternary complex PubMed 
located_in interstitial matrix  
located_in neuronal cell body  
is_active_in neuronal dense core vesicle lumen PubMed 
is_active_in neuronal dense core vesicle lumen PubMed 
located_in platelet alpha granule  
located_in postsynapse  

General protein information

Preferred Names
insulin-like growth factor 1; insulin-like growth factor I
Names
somatomedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111274.1NP_001104744.1  insulin-like growth factor 1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation from a distinct start codon and result in an isoform (3) with a novel N-terminus, compared to isoform 1. This isoform (3) is also known as IIB. This isoform (3) may undergo proteolytic processing similar to isoform 4.
    Source sequence(s)
    AC139754, AK038119, CT010364
    Consensus CDS
    CCDS48662.1
    UniProtKB/TrEMBL
    D3Z7M4, E9PU89
    Related
    ENSMUSP00000112878.2, ENSMUST00000122100.3
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  2. NM_001111275.2NP_001104745.1  insulin-like growth factor 1 isoform 4 preproprotein

    See identical proteins and their annotated locations for NP_001104745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. This isoform (4) is also known as IA.
    Source sequence(s)
    AC125082, AC139754, AK081019
    Consensus CDS
    CCDS48661.1
    UniProtKB/Swiss-Prot
    P05017, P05018, Q6LDP4, Q8C4U6
    UniProtKB/TrEMBL
    Q4VJC0, Q547V2
    Related
    ENSMUSP00000093005.5, ENSMUST00000095360.11
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  3. NM_001111276.1NP_001104746.1  insulin-like growth factor 1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a distinct start codon and result in an isoform (5) with novel N- and C-termini, compared to isoform 1. This isoform (5) is also known as IIA. This isoform (5) may undergo proteolytic processing similar to isoform 4.
    Source sequence(s)
    AC139754, AK038119, CT010364
    Consensus CDS
    CCDS48663.1
    UniProtKB/TrEMBL
    E9Q138, Q547V2
    Related
    ENSMUSP00000114120.2, ENSMUST00000121161.8
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  4. NM_001314010.1NP_001300939.1  insulin-like growth factor 1 isoform 4 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. This isoform (4) is also known as IA.
    Source sequence(s)
    AC125082, AC139754, AK081019
    Consensus CDS
    CCDS48661.1
    UniProtKB/Swiss-Prot
    P05017, P05018, Q6LDP4, Q8C4U6
    UniProtKB/TrEMBL
    Q4VJC0, Q547V2
    Related
    ENSMUSP00000113905.2, ENSMUST00000122386.8
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  5. NM_010512.5NP_034642.2  insulin-like growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034642.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This isoform (1) is also known as IB. This isoform (1) may undergo proteolytic processing similar to isoform 4.
    Source sequence(s)
    AC125082, AC139754, AI019109, AK081019
    Consensus CDS
    CCDS24104.2
    UniProtKB/TrEMBL
    D3Z7M4, Q4VJB9
    Related
    ENSMUSP00000100937.3, ENSMUST00000105300.9
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    87694127..87772909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244906.1XP_030100766.1  insulin-like growth factor I isoform X4

    Conserved Domains (1) summary
    cd04368
    Location:64131
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  2. XM_006513264.4XP_006513327.1  insulin-like growth factor I isoform X10

    UniProtKB/TrEMBL
    D3Z7M4
    Conserved Domains (1) summary
    cd04368
    Location:34101
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  3. XM_030244911.1XP_030100771.1  insulin-like growth factor I isoform X12

    UniProtKB/TrEMBL
    Q547V2
    Conserved Domains (1) summary
    cd04368
    Location:34101
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  4. XM_006513257.1XP_006513320.1  insulin-like growth factor I isoform X2

    See identical proteins and their annotated locations for XP_006513320.1

    Conserved Domains (1) summary
    cd04368
    Location:87154
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  5. XM_006513255.3XP_006513318.1  insulin-like growth factor I isoform X1

    See identical proteins and their annotated locations for XP_006513318.1

    Conserved Domains (1) summary
    cd04368
    Location:87154
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  6. XM_030244907.1XP_030100767.1  insulin-like growth factor I isoform X5

    Conserved Domains (1) summary
    cd04368
    Location:64131
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  7. XM_006513258.3XP_006513321.1  insulin-like growth factor I isoform X6

    Conserved Domains (1) summary
    cd04368
    Location:57124
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  8. XM_030244908.2XP_030100768.1  insulin-like growth factor I isoform X7

    Conserved Domains (1) summary
    cd04368
    Location:57124
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  9. XM_030244910.1XP_030100770.1  insulin-like growth factor I isoform X9

    UniProtKB/TrEMBL
    Q547V2
    Conserved Domains (1) summary
    cd04368
    Location:46113
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  10. XM_006513262.3XP_006513325.1  insulin-like growth factor I isoform X8

    UniProtKB/TrEMBL
    D3Z7M4
    Conserved Domains (1) summary
    cd04368
    Location:46113
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  11. XM_017313810.2XP_017169299.1  insulin-like growth factor I isoform X3

    Conserved Domains (1) summary
    cd04368
    Location:76143
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  12. XM_017313812.3XP_017169301.1  insulin-like growth factor I isoform X11

    UniProtKB/TrEMBL
    D3Z7M4, E9PU89
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  13. XM_017313811.1XP_017169300.1  insulin-like growth factor I isoform X11

    UniProtKB/TrEMBL
    D3Z7M4, E9PU89
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  14. XM_030244912.2XP_030100772.1  insulin-like growth factor I isoform X13

    UniProtKB/TrEMBL
    E9Q138, Q547V2
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  15. XM_036155648.1XP_036011541.1  insulin-like growth factor I isoform X11

    UniProtKB/TrEMBL
    D3Z7M4, E9PU89
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

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