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LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [ Homo sapiens (human) ]

Gene ID: 10542, updated on 10-Dec-2024

Summary

Official Symbol
LAMTOR5provided by HGNC
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5provided by HGNC
Primary source
HGNC:HGNC:17955
See related
Ensembl:ENSG00000134248 MIM:608521; AllianceGenome:HGNC:17955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XIP; HBXIP
Summary
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 162.7), bone marrow (RPKM 53.1) and 24 other tissues See more
Orthologs
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Genomic context

See LAMTOR5 in Genome Data Viewer
Location:
1p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110401253..110407924, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110416405..110423069, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110943875..110950546, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:110882428-110883166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110883828-110884393 Neighboring gene RNA binding motif protein 15 Neighboring gene solute carrier family 16 member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1471 Neighboring gene LAMTOR5 and SLC16A4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1174 Neighboring gene prokineticin 1 Neighboring gene uncharacterized LOC105378899

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hepatitis B virus x interacting protein (HBXIP) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC71071

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in TORC1 signaling PubMed 
involved_in cellular response to amino acid stimulus  
involved_in cellular response to amino acid stimulus PubMed 
involved_in cellular response to amino acid stimulus PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cysteine-type endopeptidase activity PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity PubMed 
acts_upstream_of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding PubMed 
involved_in positive regulation of TOR signaling PubMed 
involved_in positive regulation of TORC1 signaling  
involved_in positive regulation of TORC1 signaling PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
acts_upstream_of positive regulation of gene expression PubMed 
involved_in positive regulation of interleukin-8 production PubMed 
involved_in positive regulation of protein localization to nucleus PubMed 
involved_in protein localization to lysosome PubMed 
involved_in regulation of cell size PubMed 
involved_in response to virus PubMed 
involved_in viral genome replication PubMed 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP PubMed 
part_of Ragulator complex  
part_of Ragulator complex PubMed 
part_of Ragulator complex PubMed 
located_in cytosol PubMed 
located_in late endosome membrane PubMed 
is_active_in lysosomal membrane PubMed 
located_in lysosomal membrane PubMed 
located_in lysosomal membrane  
is_active_in lysosome  
located_in lysosome PubMed 
part_of protein-containing complex PubMed 

General protein information

Preferred Names
ragulator complex protein LAMTOR5
Names
HBV X-interacting protein
HBx-interacting protein
hepatitis B virus x interacting protein
hepatitis B virus x-interacting protein (9.6kD)
late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382293.1NP_001369222.1  ragulator complex protein LAMTOR5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a downstream transcription start site and a downstream in-frame translation start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL390797
    Consensus CDS
    CCDS91022.1
    UniProtKB/Swiss-Prot
    A0A0C4DGV4, O43504, Q6IBD8
    UniProtKB/TrEMBL
    E9PLX3
    Related
    ENSP00000473439.1, ENST00000602318.6
    Conserved Domains (1) summary
    pfam16672
    Location:188
    LAMTOR5; Ragulator complex protein LAMTOR5
  2. NM_006402.3NP_006393.2  ragulator complex protein LAMTOR5 isoform 1

    See identical proteins and their annotated locations for NP_006393.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). It uses upstream transcription and translation start sites, compared to variant 2.
    Source sequence(s)
    AL390797
    Consensus CDS
    CCDS824.1
    UniProtKB/TrEMBL
    A0A8Z5A536
    Related
    ENSP00000256644.4, ENST00000256644.8
    Conserved Domains (1) summary
    pfam16672
    Location:83170
    LAMTOR5; Ragulator complex protein LAMTOR5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    110401253..110407924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    110416405..110423069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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