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Full record GDS5337

Heat shock protein 90 inhibitor effect on Huntington’s disease model: brain striatum

Analysis of R6/2 Huntington’s disease (HD) model treated with 12mg/kg HSP990 for 4h. HSP990, a brain-penetrant HSP90 inhibitor, activates heat shock response (HSR) and alters HD-related phenotypes. Results provide insight into molecular mechanisms underlying impaired HSR-mediated HD progression.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL1261
Series:
GSE29681
32 Samples
Download data: CEL

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