U.S. flag

An official website of the United States government

Fat3 FAT atypical cadherin 3 [ Mus musculus (house mouse) ]

Gene ID: 270120, updated on 9-Dec-2024

Summary

Official Symbol
Fat3provided by MGI
Official Full Name
FAT atypical cadherin 3provided by MGI
Primary source
MGI:MGI:2444314
See related
Ensembl:ENSMUSG00000074505 AllianceGenome:MGI:2444314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm510; Gm1132; MFAT3F; 9430076A06Rik; D430038H04Rik
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within generation of neurons; negative regulation of dendrite development; and retina layer formation. Located in dendrite. Is expressed in several structures, including brain; foregut; ganglia; sensory organ; and skeleton. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in whole brain E14.5 (RPKM 3.7), frontal lobe adult (RPKM 3.2) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fat3 in Genome Data Viewer
Location:
9 A2; 9 5.16 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15821485..16413981, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15910189..16502681, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 4 Neighboring gene STARR-seq mESC enhancer starr_23387 Neighboring gene melatonin receptor 1B Neighboring gene STARR-seq mESC enhancer starr_23388 Neighboring gene STARR-seq mESC enhancer starr_23389 Neighboring gene STARR-seq mESC enhancer starr_23390 Neighboring gene STARR-seq mESC enhancer starr_23391 Neighboring gene STARR-seq mESC enhancer starr_23392 Neighboring gene STARR-seq mESC enhancer starr_23393 Neighboring gene predicted gene, 53499 Neighboring gene STARR-seq mESC enhancer starr_23398 Neighboring gene STARR-seq mESC enhancer starr_23400 Neighboring gene STARR-seq mESC enhancer starr_23401 Neighboring gene STARR-seq mESC enhancer starr_23402 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 53500

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding  
Component Evidence Code Pubs
located_in dendrite PubMed 
located_in plasma membrane  

General protein information

Preferred Names
protocadherin Fat 3
Names
FAT tumor suppressor homolog 3
protocadherin Fat3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080814.2NP_001074283.2  protocadherin Fat 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154406, AC154741, AC159817, AC161370, AC162903
    Consensus CDS
    CCDS40539.2
    UniProtKB/Swiss-Prot
    Q08ED4, Q8BNA6
    UniProtKB/TrEMBL
    E9QK16
    Related
    ENSMUSP00000080808.6, ENSMUST00000082170.6
    Conserved Domains (4) summary
    cd11304
    Location:10481143
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:285372
    CA; Cadherin repeats
    cd00054
    Location:40974132
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:38643992
    Laminin_G_2; Laminin G domain
  2. NM_001413471.1NP_001400400.1  protocadherin Fat 3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154406, AC154741, AC159817, AC161370, AC162903
    UniProtKB/TrEMBL
    E9QK16

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15821485..16413981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242542.4XP_011240844.1  protocadherin Fat 3 isoform X5

    UniProtKB/TrEMBL
    E9QK16
    Conserved Domains (4) summary
    cd11304
    Location:10491144
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:286373
    CA; Cadherin repeats
    cd00054
    Location:41214156
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:38884014
    Laminin_G_2; Laminin G domain
  2. XM_011242541.4XP_011240843.1  protocadherin Fat 3 isoform X3

    UniProtKB/TrEMBL
    E9QK16
    Conserved Domains (4) summary
    cd11304
    Location:10491144
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:286373
    CA; Cadherin repeats
    cd00054
    Location:41214156
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:38884014
    Laminin_G_2; Laminin G domain
  3. XM_017313398.3XP_017168887.1  protocadherin Fat 3 isoform X2

    UniProtKB/TrEMBL
    E9QK16
    Conserved Domains (4) summary
    cd11304
    Location:10491144
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:286373
    CA; Cadherin repeats
    cd00054
    Location:41214156
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:38884014
    Laminin_G_2; Laminin G domain
  4. XM_011242543.4XP_011240845.1  protocadherin Fat 3 isoform X1

    UniProtKB/TrEMBL
    E9QK16
    Conserved Domains (4) summary
    cd11304
    Location:10491144
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:286373
    CA; Cadherin repeats
    cd00054
    Location:41214156
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:38884014
    Laminin_G_2; Laminin G domain
  5. XM_030244399.2XP_030100259.1  protocadherin Fat 3 isoform X6

    Conserved Domains (3) summary
    cd11304
    Location:21072203
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:29642999
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:27312857
    Laminin_G_2; Laminin G domain
  6. XM_036155026.1XP_036010919.1  protocadherin Fat 3 isoform X7

    Conserved Domains (2) summary
    cd11304
    Location:10491144
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:286373
    CA; Cadherin repeats
  7. XM_036155027.1XP_036010920.1  protocadherin Fat 3 isoform X8

    Conserved Domains (2) summary
    cd11304
    Location:10491144
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:286373
    CA; Cadherin repeats
External link. Please review our privacy policy.