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Spp2 secreted phosphoprotein 2 [ Mus musculus (house mouse) ]

Gene ID: 75396, updated on 9-Dec-2024

Summary

Official Symbol
Spp2provided by MGI
Official Full Name
secreted phosphoprotein 2provided by MGI
Primary source
MGI:MGI:1922646
See related
Ensembl:ENSMUSG00000026295 AllianceGenome:MGI:1922646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pp-24; spp24; 0610038O04Rik
Summary
Predicted to be involved in protein-containing complex assembly. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Is expressed in embryo endoderm; liver lobe; urinary system; and yolk sac. Orthologous to human SPP2 (secreted phosphoprotein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in placenta adult (RPKM 478.7), kidney adult (RPKM 348.4) and 4 other tissues See more
Orthologs
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Genomic context

See Spp2 in Genome Data Viewer
Location:
1 D; 1 44.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88334688..88356022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88406966..88428300)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene STARR-seq mESC enhancer starr_01631 Neighboring gene STARR-seq mESC enhancer starr_01632 Neighboring gene STARR-seq mESC enhancer starr_01633 Neighboring gene predicted gene 29538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:90371230-90371404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:90372096-90372342 Neighboring gene predicted gene 28888 Neighboring gene glutamine repeat protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3) 

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in extracellular region  
part_of protein-containing complex  

General protein information

Preferred Names
secreted phosphoprotein 24
Names
secreted phosphoprotein 2, 24kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029269.3NP_083545.1  secreted phosphoprotein 24 precursor

    See identical proteins and their annotated locations for NP_083545.1

    Status: VALIDATED

    Source sequence(s)
    AK002814, BY787973
    Consensus CDS
    CCDS15145.1
    UniProtKB/Swiss-Prot
    Q8K1I3, Q9DCG1
    UniProtKB/TrEMBL
    Q711L0
    Related
    ENSMUSP00000027518.6, ENSMUST00000027518.12
    Conserved Domains (2) summary
    pfam07448
    Location:67203
    Spp-24; Secreted phosphoprotein 24 (Spp-24)
    cl09238
    Location:32100
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    88334688..88356022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529918.3XP_006529981.1  secreted phosphoprotein 24 isoform X1

    Conserved Domains (2) summary
    cl09238
    Location:3299
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
    cl29764
    Location:67108
    Cathelicidins
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