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Items: 1 to 20 of 124

1.
KIF14 Promotes AKT Phosphorylation and Contributes to Chemoresistance in Triple-Negative Breast Cancer
Stina M. Singel, Crystal Cornelius, Elma Zaganjor, Kimberly Batten, Venetia R. Sarode, Dennis L. Buckley, Yan Peng, George B. John, Hsiao C. Li, Navid Sadeghi, Woodring E. Wright, Lawrence Lum, Timothy W. Corson, Jerry W. Shay
Neoplasia. 2014 Mar; 16(3): 247–256.e2. Published online 2014 May 6. doi: 10.1016/j.neo.2014.03.008
PMCID:
PMC4094827
ArticlePDF–1.5M
2.
BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation
Yixin Yao, Milind Suraokar, Bryant G. Darnay, Brett G. Hollier, Tattym E. Shaiken, Takayuki Asano, Chien-Hung Chen, Benny H.-J. Chang, Yiling Lu, Gordon B. Mills, Dos Sarbassov, Sendurai A. Mani, James L. Abbruzzese, Shrikanth A. G. Reddy
Sci Signal. Author manuscript; available in PMC 2013 Aug 21.
Published in final edited form as: Sci Signal. 2013 Jan 8; 6(257): ra2. Published online 2013 Jan 8. doi: 10.1126/scisignal.2003295
PMCID:
PMC3748614
ArticlePDF–3.5M
3.
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies
Rocky Cipriano, Kristy L.S. Miskimen, Benjamin L. Bryson, Chase R. Foy, Courtney A. Bartel, Mark W. Jackson
Oncotarget. 2013 May; 4(5): 729–738. Published online 2013 May 11. doi: 10.18632/oncotarget.1027
PMCID:
PMC3742833
ArticlePDF–1.6M
4.
CSTP1, a Novel Protein Phosphatase, Blocks Cell Cycle, Promotes Cell Apoptosis, and Suppresses Tumor Growth of Bladder Cancer by Directly Dephosphorylating Akt at Ser473 Site
De-Xiang Zhuo, Xiao-Wei Zhang, Bo Jin, Zheng Zhang, Bu-Shan Xie, Cheng-Lin Wu, Kan Gong, Ze-Bin Mao
PLoS One. 2013; 8(6): e65679. Published online 2013 Jun 17. doi: 10.1371/journal.pone.0065679
PMCID:
PMC3684612
ArticlePDF–7.2M
5.
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
Susumu Rokudai, Oleg Laptenko, Suzzette M. Arnal, Yoichi Taya, Issay Kitabayashi, Carol Prives
Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10): 3895–3900. Published online 2013 Feb 19. doi: 10.1073/pnas.1300490110
PMCID:
PMC3593914
ArticlePDF–1.0M
6.
Germline PIK3CA and AKT1 Mutations in Cowden and Cowden-like Syndromes
Mohammed S. Orloff, Xin He, Charissa Peterson, Fusong Chen, Jin-Lian Chen, Jessica L. Mester, Charis Eng
Am J Hum Genet. 2013 Jan 10; 92(1): 76–80. doi: 10.1016/j.ajhg.2012.10.021
PMCID:
PMC3542473
ArticlePDF–354K
7.
Microarray-Assisted Pathway Analysis Identifies MT1X & NFκB as Mediators of TCRP1-Associated Resistance to Cisplatin in Oral Squamous Cell Carcinoma
Bo Peng, Yixue Gu, Yan Xiong, Guopei Zheng, Zhimin He
PLoS One. 2012; 7(12): e51413. Published online 2012 Dec 10. doi: 10.1371/journal.pone.0051413
PMCID:
PMC3519677
ArticlePDF–1.1M
8.
Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling
Shuai Wang, Xun Huang, Danni Sun, Xianliang Xin, Qiuming Pan, Shuying Peng, Zhongjie Liang, Cheng Luo, Yiming Yang, Hualiang Jiang, Min Huang, Wengang Chai, Jian Ding, Meiyu Geng
PLoS One. 2012; 7(5): e37427. Published online 2012 May 22. doi: 10.1371/journal.pone.0037427
PMCID:
PMC3358304
ArticlePDF–3.3M
9.
Akt is negatively regulated by the MULAN E3 ligase
Seunghee Bae, Sun-Yong Kim, Jin Hyuk Jung, Yeongmin Yoon, Hwa Jun Cha, Hyunjin Lee, Karam Kim, Jongran Kim, In-Sook An, Jongdoo Kim, Hong-Duck Um, In-Chul Park, Su-Jae Lee, Seon Young Nam, Young-Woo Jin, Jae Ho Lee, Sungkwan An
Cell Res. 2012 May; 22(5): 873–885. Published online 2012 Mar 13. doi: 10.1038/cr.2012.38
PMCID:
PMC3343661
ArticlePDF–1.3M
10.
A Mosaic Activating Mutation in AKT1 Associated with the Proteus Syndrome
Marjorie J. Lindhurst, Julie C. Sapp, Jamie K. Teer, Jennifer J. Johnston, Erin M. Finn, Kathryn Peters, Joyce Turner, Jennifer L. Cannons, David Bick, Laurel Blakemore, Catherine Blumhorst, Knut Brockmann, Peter Calder, Natasha Cherman, Matthew A. Deardorff, David B. Everman, Gretchen Golas, Robert M. Greenstein, B. Maya Kato, Kim M. Keppler-Noreuil, Sergei A. Kuznetsov, Richard T. Miyamoto, Kurt Newman, David Ng, Kevin O’Brien, Steven Rothenberg, Douglas J. Schwartzentruber, Virender Singhal, Roberto Tirabosco, Joseph Upton, Shlomo Wientroub, Elaine H. Zackai, Kimberly Hoag, Tracey Whitewood-Neal, Pamela G. Robey, Pamela L. Schwartzberg, Thomas N. Darling, Laura L. Tosi, James C. Mullikin, Leslie G. Biesecker
N Engl J Med. Author manuscript; available in PMC 2012 Feb 18.
Published in final edited form as: N Engl J Med. 2011 Aug 18; 365(7): 611–619. Published online 2011 Jul 27. doi: 10.1056/NEJMoa1104017
PMCID:
PMC3170413
ArticlePDF–847K
11.
IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation
Xiaoduo Xie, Denghong Zhang, Bin Zhao, Min-Kan Lu, Ming You, Gianluigi Condorelli, Cun-Yu Wang, Kun-Liang Guan
Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16): 6474–6479. Published online 2011 Apr 4. doi: 10.1073/pnas.1016132108
PMCID:
PMC3081021
ArticlePDF–808K
12.
Clk2 and B56β mediate insulin regulated assembly of the PP2A phosphatase holoenzyme complex on Akt
Joseph T. Rodgers, Rutger Vogel, Pere Puigserver
Mol Cell. Author manuscript; available in PMC 2012 Feb 18.
Published in final edited form as: Mol Cell. 2011 Feb 18; 41(4): 471–479. doi: 10.1016/j.molcel.2011.02.007
PMCID:
PMC3060660
ArticlePDF–1.1M
13.
Initial characterization of the human central proteome
Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge
BMC Syst Biol. 2011; 5: 17. Published online 2011 Jan 26. doi: 10.1186/1752-0509-5-17
PMCID:
PMC3039570
ArticlePDF–2.3M
14.
The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
Wei-Lei Yang, Jing Wang, Chia-Hsin Chan, Szu-Wei Lee, Alejandro D. Campos, Lana Hur, Brian Grabiner, Xin Lin, Bryant G. Darnay, Hui-Kuan Lin
Science. Author manuscript; available in PMC 2010 Dec 23.
Published in final edited form as: Science. 2009 Aug 28; 325(5944): 1134–1138. doi: 10.1126/science.1175065
PMCID:
PMC3008763
ArticlePDF–762K
15.
Phosphorylation of CLK2 at Serine 34 and Threonine 127 by AKT Controls Cell Survival after Ionizing Radiation
Seon Young Nam, Hyung Ho Seo, Hyung Sun Park, Sungkwan An, Ji-Young Kim, Kwang Hee Yang, Cha Soon Kim, Meeseon Jeong, Young-Woo Jin
J Biol Chem. 2010 Oct 8; 285(41): 31157–31163. Published online 2010 Aug 3. doi: 10.1074/jbc.M110.122044
PMCID:
PMC2951189
ArticlePDF–1.3M
16.
Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
Wen-I Wu, Walter C. Voegtli, Hillary L. Sturgis, Faith P. Dizon, Guy P. A. Vigers, Barbara J. Brandhuber
PLoS One. 2010; 5(9): e12913. Published online 2010 Sep 23. doi: 10.1371/journal.pone.0012913
PMCID:
PMC2944833
ArticlePDF–918K
17.
Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain
Kyle E. Landgraf, Carissa Pilling, Joseph J. Falke
Biochemistry. Author manuscript; available in PMC 2010 Aug 10.
Published in final edited form as: Biochemistry. 2008 Nov 25; 47(47): 12260–12269. doi: 10.1021/bi801683k
PMCID:
PMC2919500
ArticlePDF–2.3M
18.
Co-operation between Raf-1 and Akt pathways for the inhibition of RASSF1A-MST2-triggered apoptosis
David Romano, David Matallanas, Gregory Weitsman, Christian Preisinger, Tony Ng, Walter Kolch
Cancer Res. Author manuscript; available in PMC 2010 Aug 1.
Published in final edited form as: Cancer Res. 2010 Feb 1; 70(3): 1195–1203. Published online 2010 Jan 19. doi: 10.1158/0008-5472.CAN-09-3147
PMCID:
PMC2880716
ArticlePDF–2.1M
19.
THE ACTIN BUNDLING PROTEIN PALLADIN IS AN AKT1-SPECIFIC SUBSTRATE THAT REGULATES BREAST CANCER CELL MIGRATION
Y. Rebecca Chin, Alex Toker
Mol Cell. Author manuscript; available in PMC 2011 May 14.
Published in final edited form as: Mol Cell. 2010 May 14; 38(3): 333–344. doi: 10.1016/j.molcel.2010.02.031
PMCID:
PMC2872630
ArticlePDF–2.2M
20.
Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
Kiran Mahajan, Domenico Coppola, Sridevi Challa, Bin Fang, Y. Ann Chen, Weiwei Zhu, Alexis S. Lopez, John Koomen, Robert W. Engelman, Charlene Rivera, Rebecca S. Muraoka-Cook, Jin Q. Cheng, Ernst Schönbrunn, Said M. Sebti, H. Shelton Earp, Nupam P. Mahajan
PLoS One. 2010; 5(3): e9646. Published online 2010 Mar 19. doi: 10.1371/journal.pone.0009646
PMCID:
PMC2841635
ArticlePDF–1.8M

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