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Select item 47038821.

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

Najim Ameziane, Patrick May, Anneke Haitjema, Henri J. van de Vrugt, Sari E. van Rossum-Fikkert, Dejan Ristic, Gareth J. Williams, Jesper Balk, Davy Rockx, Hong Li, Martin A. Rooimans, Anneke B. Oostra, Eunike Velleuer, Ralf Dietrich, Onno B. Bleijerveld, A. F. Maarten Altelaar, Hanne Meijers-Heijboer, Hans Joenje, Gustavo Glusman, Jared Roach, Leroy Hood, David Galas, Claire Wyman, Rudi Balling, Johan den Dunnen, Johan P. de Winter, Roland Kanaar, Richard Gelinas, Josephine C. Dorsman

Nat Commun. 2015; 6: 8829. Published online 2015 Dec 18. doi: 10.1038/ncomms9829

PMCID:: PMC4703882

Article PDF–1.8M

Select item 45299642.

A dominant mutation in human RAD51 reveals its function in DNA interstrand crosslink repair independent of homologous recombination

Anderson T. Wang, Taeho Kim, John E. Wagner, Brooke A. Conti, Francis P. Lach, Athena L. Huang, Henrik Molina, Erica M. Sanborn, Heather Zierhut, Belinda K. Cornes, Avinash Abhyankar, Carrie Sougnez, Stacey B. Gabriel, Arleen D. Auerbach, Stephen C. Kowalczykowski, Agata Smogorzewska

Mol Cell. Author manuscript; available in PMC 2016 Aug 6.

Published in final edited form as: Mol Cell. 2015 Aug 6; 59(3): 478–490. doi: 10.1016/j.molcel.2015.07.009

PMCID:: PMC4529964

Article PDF–3.3M

Select item 44156023.

Homologous recombination-deficient tumors are hyper-dependent on POLQ-mediated repair

Raphael Ceccaldi, Jessica C. Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I.R. Petalcorin, Kevin W. O'Connor, Panagiotis A. Konstantinopoulos, Stephen J. Elledge, Simon J. Boulton, Timur Yusufzai, Alan D. D'Andrea

Nature. Author manuscript; available in PMC 2015 Aug 12.

Published in final edited form as: Nature. 2015 Feb 12; 518(7538): 258–262. Published online 2015 Feb 2. doi: 10.1038/nature14184

PMCID:: PMC4415602

Article PDF–1.3M

Select item 43333884.

Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase

Jianhong Chen, Milagros D. Morrical, Katherine A. Donigan, Joanne B. Weidhaas, Joann B. Sweasy, April M. Averill, Jennifer A. Tomczak, Scott W. Morrical

Nucleic Acids Res. 2015 Jan 30; 43(2): 1098–1111. Published online 2014 Dec 24. doi: 10.1093/nar/gku1337

PMCID:: PMC4333388

Article PDF–1.6M

Select item 40941075.

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

Rémi Buisson, Anne-Marie Dion-Côté, Yan Coulombe, Hélène Launay, Hong Cai, Alicja Z. Stasiak, Andrzej Stasiak, Bing Xia, Jean-Yves Masson

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 Jul 11.

Published in final edited form as: Nat Struct Mol Biol. 2010 Oct; 17(10): 1247–1254. Published online 2010 Sep 26. doi: 10.1038/nsmb.1915

PMCID:: PMC4094107

Article PDF–2.6M

Select item 39941866.

BREAST CANCER-ASSOCIATED MISSENSE MUTANTS OF THE PALB2 WD40 DOMAIN, WHICH DIRECTLY BINDS RAD51C, RAD51 AND BRCA2, DISRUPT DNA REPAIR

Jung-Young Park, Thiyam R. Singh, Nicolas Nassar, Fan Zhang, Marcel Freund, Helmut Hanenberg, Amom Ruhikanta Meetei, Paul R. Andreassen

Oncogene. Author manuscript; available in PMC 2015 Apr 2.

Published in final edited form as: Oncogene. 2014 Oct 2; 33(40): 4803–4812. Published online 2013 Oct 21. doi: 10.1038/onc.2013.421

PMCID:: PMC3994186

Article PDF–1.2M

Select item 37962017.

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization

Anand D Jeyasekharan, Yang Liu, Hiroyoshi Hattori, Venkat Pisupati, Asta Bjork Jonsdottir, Eeson Rajendra, Miyoung Lee, Elayanambi Sundaramoorthy, Simon Schlachter, Clemens Kaminski, Yaara Ofir-Rosenfeld, Ko Sato, Jane Savill, Nabieh Ayoub, Ashok R Venkitaraman

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Nat Struct Mol Biol. 2013 Oct; 20(10): 1191–1198. Published online 2013 Sep 8. doi: 10.1038/nsmb.2666

PMCID:: PMC3796201

Article PDF–978K

Select item 36968238.

FIGNL1-containing protein complex is required for efficient homologous recombination repair

Jingsong Yuan, Junjie Chen

Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26): 10640–10645. Published online 2013 Jun 10. doi: 10.1073/pnas.1220662110

PMCID:: PMC3696823

Article PDF–1.0M

Select item 36967699.

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

Li Wan, Jinhua Han, Ting Liu, Shunli Dong, Feng Xie, Hongxia Chen, Jun Huang

Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26): 10646–10651. Published online 2013 Mar 18. doi: 10.1073/pnas.1220921110

PMCID:: PMC3696769

Article PDF–804K

Select item 362424410.

The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites To Facilitate Homologous Recombination

Jonghoon Park, David T. Long, Kyung Yong Lee, Tarek Abbas, Etsuko Shibata, Masamitsu Negishi, Yunhai Luo, John C. Schimenti, Agnieszka Gambus, Johannes C. Walter, Anindya Dutta

Mol Cell Biol. 2013 Apr; 33(8): 1632–1644. doi: 10.1128/MCB.01503-12

PMCID:: PMC3624244

Article PDF–2.1M

Select item 361671711.

Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase

Tokiha Masuda-Ozawa, Trish Hoang, Yeon-Soo Seo, Lin-Feng Chen, Maria Spies

Nucleic Acids Res. 2013 Apr; 41(6): 3576–3587. Published online 2013 Feb 6. doi: 10.1093/nar/gkt056

PMCID:: PMC3616717

Article PDF–2.9M

Select item 341203112.

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB

Petra Van Damme, Marta Lasa, Bogdan Polevoda, Cristina Gazquez, Alberto Elosegui-Artola, Duk Soo Kim, Elena De Juan-Pardo, Kimberly Demeyer, Kristine Hole, Esther Larrea, Evy Timmerman, Jesus Prieto, Thomas Arnesen, Fred Sherman, Kris Gevaert, Rafael Aldabe

Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31): 12449–12454. Published online 2012 Jul 18. doi: 10.1073/pnas.1210303109

PMCID:: PMC3412031

Article PDF–958K

Select item 330888413.

hSWS1·SWSAP1 Is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair

Ting Liu, Li Wan, Yue Wu, Junjie Chen, Jun Huang

J Biol Chem. 2011 Dec 2; 286(48): 41758–41766. Published online 2011 Sep 29. doi: 10.1074/jbc.M111.271080

PMCID:: PMC3308884

Article PDF–1.8M

Select item 327666814.

RAD51 Haploinsufficiency Causes Congenital Mirror Movements in Humans

Christel Depienne, Delphine Bouteiller, Aurélie Méneret, Ségolène Billot, Sergiu Groppa, Stephan Klebe, Fanny Charbonnier-Beaupel, Jean-Christophe Corvol, Jean-Paul Saraiva, Norbert Brueggemann, Kailash Bhatia, Massimo Cincotta, Vanessa Brochard, Constance Flamand-Roze, Wassila Carpentier, Sabine Meunier, Yannick Marie, Marion Gaussen, Giovanni Stevanin, Rosine Wehrle, Marie Vidailhet, Christine Klein, Isabelle Dusart, Alexis Brice, Emmanuel Roze

Am J Hum Genet. 2012 Feb 10; 90(2): 301–307. doi: 10.1016/j.ajhg.2011.12.002

PMCID:: PMC3276668

Article PDF–1.0M

Select item 326732415.

Inhibition of homologous recombination by the PCNA-interacting protein PARI

George-Lucian Moldovan, Donniphat Dejsuphong, Mark I. R. Petalcorin, Kay Hofmann, Shunichi Takeda, Simon J. Boulton, Alan D. D’Andrea

Mol Cell. Author manuscript; available in PMC 2013 Jan 13.

Published in final edited form as: Mol Cell. 2012 Jan 13; 45(1): 75–86. Published online 2011 Dec 6. doi: 10.1016/j.molcel.2011.11.010

PMCID:: PMC3267324

Article PDF–3.7M

Select item 305904816.

The Role of the Human SWI5-MEI5 Complex in Homologous Recombination Repair

Jingsong Yuan, Junjie Chen

J Biol Chem. 2011 Mar 18; 286(11): 9888–9893. Published online 2011 Jan 20. doi: 10.1074/jbc.M110.207290

PMCID:: PMC3059048

Article PDF–949K

Select item 305714017.

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

Dong-Hyun Lee, Yunfeng Pan, Shlomo Kanner, Patrick Sung, James A Borowiec, Dipanjan Chowdhury

Nat Struct Mol Biol. Author manuscript; available in PMC 2011 Mar 15.

Published in final edited form as: Nat Struct Mol Biol. 2010 Mar; 17(3): 365–372. Published online 2010 Feb 14. doi: 10.1038/nsmb.1769

PMCID:: PMC3057140

Article PDF–1.5M

Select item 292899418.

Regulation of DNA Repair through De-SUMOylation and SUMOylation of Replication Protein A Complex

Hong Dou, Chao Huang, Melissa Singh, Phillip B Carpenter, Edward T. H. Yeh

Mol Cell. Author manuscript; available in PMC 2011 Aug 13.

Published in final edited form as: Mol Cell. 2010 Aug 13; 39(3): 333–345. doi: 10.1016/j.molcel.2010.07.021

PMCID:: PMC2928994

Article PDF–2.3M

Select item 288517519.

Discovery of a Novel Function for Human Rad51: MAINTENANCE OF THE MITOCHONDRIAL GENOME

Jay M. Sage, Otto S. Gildemeister, Kendall L. Knight

J Biol Chem. 2010 Jun 18; 285(25): 18984–18990. Published online 2010 Apr 22. doi: 10.1074/jbc.M109.099846

PMCID:: PMC2885175

Article PDF–1.0M

Select item 287144020.

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity

Sybille Schwendener, Steven Raynard, Shreya Paliwal, Anita Cheng, Radhakrishnan Kanagaraj, Igor Shevelev, Jeremy M. Stark, Patrick Sung, Pavel Janscak

J Biol Chem. 2010 May 21; 285(21): 15739–15745. Published online 2010 Mar 25. doi: 10.1074/jbc.M110.110478

PMCID:: PMC2871440

Article PDF–1.6M

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