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Items: 1 to 20 of 35

1.
Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone and their combination as endogenous probes for inhibition of CYP3A4 in vivo
Chi-Chi Peng, Ian Templeton, Kenneth E Thummel, Connie Davis, Kent L Kunze, Nina Isoherranen
Clin Pharmacol Ther. Author manuscript; available in PMC 2012 Oct 26.
Published in final edited form as: Clin Pharmacol Ther. 2011 Jun; 89(6): 888–895. Published online 2011 Apr 13. doi: 10.1038/clpt.2011.53
PMCID:
PMC3481835
ArticlePDF–502K
2.
Oxidation of Dihydrotestosterone by Human Cytochromes P450 19A1 and 3A4
Qian Cheng, Christal D. Sohl, Francis K. Yoshimoto, F. Peter Guengerich
J Biol Chem. 2012 Aug 24; 287(35): 29554–29567. Published online 2012 Jul 7. doi: 10.1074/jbc.M112.390047
PMCID:
PMC3436178
ArticlePDF–2.2M
3.
Cholesterol 25-hydroxylation activity of CYP3A
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki
J Lipid Res. 2011 Aug; 52(8): 1509–1516. doi: 10.1194/jlr.M014084
PMCID:
PMC3137016
ArticlePDF–773K
4.
Effects of a Commonly Occurring Genetic Polymorphism of Human CYP3A4 (I118V) on the Metabolism of Anandamide
Matthew Pratt-Hyatt, Haoming Zhang, Natasha T. Snider, Paul F. Hollenberg
Drug Metab Dispos. 2010 Nov; 38(11): 2075–2082. doi: 10.1124/dmd.110.033712
PMCID:
PMC2967395
ArticlePDF–1.3M
5.
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
Michael K. Pabarcus, Nicholas Hoe, Sheila Sadeghi, Cam Patterson, Emmanuel Wiertz, Maria Almira Correia
Arch Biochem Biophys. Author manuscript; available in PMC 2010 Jun 7.
Published in final edited form as: Arch Biochem Biophys. 2009 Mar 1; 483(1): 66–74. Published online 2008 Dec 10. doi: 10.1016/j.abb.2008.12.001
PMCID:
PMC2881844
ArticlePDF–1.4M
6.
Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450
Danièle Lucas, Sophie Goulitquer, Jan Marienhagen, Maude Fer, Yvonne Dreano, Ulrich Schwaneberg, Yolande Amet, Laurent Corcos
J Lipid Res. 2010 May; 51(5): 1125–1133. doi: 10.1194/jlr.M003061
PMCID:
PMC2853439
ArticlePDF–801K
7.
Drug Metabolism in Human Brain: High Levels of Cytochrome P4503A43 in Brain and Metabolism of Anti-Anxiety Drug Alprazolam to Its Active Metabolite
Varsha Agarwal, Reddy P. Kommaddi, Khader Valli, Daniel Ryder, Thomas M. Hyde, Joel E. Kleinman, Henry W. Strobel, Vijayalakshmi Ravindranath
PLoS One. 2008; 3(6): e2337. Published online 2008 Jun 11. doi: 10.1371/journal.pone.0002337
PMCID:
PMC2408964
ArticlePDF–499K
8.
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes
Helen C Rawden, Gilbert O Kokwaro, Stephen A Ward, Geoffrey Edwards
Br J Clin Pharmacol. 2000 Apr; 49(4): 313–322. doi: 10.1046/j.1365-2125.2000.00170.x
PMCID:
PMC2014938
ArticlePDF–276K
9.
Identification of an inducible form of cytochrome P-450 in human liver.
P B Watkins, S A Wrighton, P Maurel, E G Schuetz, G Mendez-Picon, G A Parker, P S Guzelian
Proc Natl Acad Sci U S A. 1985 Sep; 82(18): 6310–6314. doi: 10.1073/pnas.82.18.6310
PMCID:
PMC391043
ArticlePDF–1.2M
10.
Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.
P H Beaune, D R Umbenhauer, R W Bork, R S Lloyd, F P Guengerich
Proc Natl Acad Sci U S A. 1986 Nov; 83(21): 8064–8068. doi: 10.1073/pnas.83.21.8064
PMCID:
PMC386867
ArticlePDF–1.1M
11.
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
D T Molowa, E G Schuetz, S A Wrighton, P B Watkins, P Kremers, G Mendez-Picon, G A Parker, P S Guzelian
Proc Natl Acad Sci U S A. 1986 Jul; 83(14): 5311–5315. doi: 10.1073/pnas.83.14.5311
PMCID:
PMC323941
ArticlePDF–1.2M
12.
Integrating Pharmacokinetics Study, Network Analysis, and Experimental Validation to Uncover the Mechanism of Qiliqiangxin Capsule Against Chronic Heart Failure
Yu Zhang, Mingdan Zhu, Fugeng Zhang, Shaoqiang Zhang, Wuxun Du, Xuefeng Xiao
Front Pharmacol. 2019; 10: 1046. Published online 2019 Sep 18. doi: 10.3389/fphar.2019.01046
PMCID:
PMC6759796
ArticlePDF–2.4M
13.
Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis
Dan Wang, Ruisheng Li, Shizhang Wei, Sijia Gao, Zhuo Xu, Honghong Liu, Ruilin Wang, Haotian Li, Huadan Cai, Jian Wang, Yanling Zhao
Chin Med. 2019; 14: 30. Published online 2019 Aug 28. doi: 10.1186/s13020-019-0251-z
PMCID:
PMC6712842
ArticlePDF–6.3M
14.
Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis
Naiqiang Zhu, Jingyi Hou, Guiyun Ma, Jinxin Liu
Med Sci Monit. 2019; 25: 6051–6073. Published online 2019 Aug 14. doi: 10.12659/MSM.915821
PMCID:
PMC6705180
ArticlePDF–7.1M
15.
In silico comparative molecular docking analysis and analysis of the anti-inflammatory mechanisms of action of tanshinone from Salvia miltiorrhiza
Zhengshang Ruan, Lei Niu, Li Han, Rongrong Ren, Zhenyu Xu, Wenwen Dong, Lai Jiang
Exp Ther Med. 2019 Aug; 18(2): 1131–1140. Published online 2019 Jun 18. doi: 10.3892/etm.2019.7679
PMCID:
PMC6601134
ArticlePDF–1.0M
16.
The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology
Guilin Ren, Yu Zhong, Gang Ke, Xiaoli Liu, Huiting Li, Xiaofang Li, Qin Zheng, Ming Yang
Evid Based Complement Alternat Med. 2019; 2019: 9241403. Published online 2019 Jun 4. doi: 10.1155/2019/9241403
PMCID:
PMC6582871
ArticlePDF–1.5M
17.
Interaction of human drug-metabolizing CYP3A4 with small inhibitory molecules
Irina Sevrioukova
Biochemistry. Author manuscript; available in PMC 2020 Feb 19.
Published in final edited form as: Biochemistry. 2019 Feb 19; 58(7): 930–939. Published online 2019 Jan 24. doi: 10.1021/acs.biochem.8b01221
PMCID:
PMC6448587
ArticlePDF–1006K
18.
System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia
Chun Wang, Qing Ren, Xue-Tong Chen, Zhi-Qian Song, Zhang-Chi Ning, Jia-He Gan, Xin-Ling Ma, Dong-Rui Liang, Dao-Gang Guan, Zhen-Li Liu, Ai-Ping Lu
Front Pharmacol. 2018; 9: 841. Published online 2018 Aug 6. doi: 10.3389/fphar.2018.00841
PMCID:
PMC6087764
ArticlePDF–4.7M
19.
In silico prediction of potential chemical reactions mediated by human enzymes
Myeong-Sang Yu, Hyang-Mi Lee, Aaron Park, Chungoo Park, Hyithaek Ceong, Ki-Hyeong Rhee, Dokyun Na
BMC Bioinformatics. 2018; 19(Suppl 8): 207. Published online 2018 Jun 13. doi: 10.1186/s12859-018-2194-2
PMCID:
PMC5998764
ArticlePDF–1.0M
20.
PTS: a pharmaceutical target seeker
Peng Ding, Xin Yan, Zhihong Liu, Jiewen Du, Yunfei Du, Yutong Lu, Di Wu, Yuehua Xu, Huihao Zhou, Qiong Gu, Jun Xu
Database (Oxford) 2017; 2017: bax095. Published online 2017 Dec 28. doi: 10.1093/database/bax095
PMCID:
PMC5750839
ArticlePDF–547K

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