PMC Articles for PubChem Compound (Select 71715374) - PMC

Select item 109499131.

Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts

Yasuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O. Holland, Erin Beck, Zina Itkin, Crystal McKnight, Kelli M. Wilson, Jameson Travers, Carleen Klumpp-Thomas, Craig J. Thomas, Chuong D. Hoang, Jonathan M. Hernandez, Jaydira Del Rivero, Yves Pommier

Cancer Res Commun. 2024 Mar; 4(3): 834–848. Published online 2024 Mar 19. doi: 10.1158/2767-9764.CRC-24-0085

PMCID:: PMC10949913

Abstract Article PDF–11M

Select item 104797432.

Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma

Srirupa Bhattacharyya, Janet L Oblinger, Roberta L Beauchamp, Zhenzhen Yin, Serkan Erdin, Priya Koundinya, Anna D Ware, Marc Ferrer, Justin T Jordan, Scott R Plotkin, Lei Xu, Long-Sheng Chang, Vijaya Ramesh

Neuro Oncol. 2023 Sep; 25(9): 1617–1630. Published online 2023 Feb 20. doi: 10.1093/neuonc/noad037

PMCID:: PMC10479743

Abstract Article PDF–7.7M

Select item 102588143.

ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1

Zhuoxun Wu, Yuqi Yang, Zining Lei, Silpa Narayanan, Jingquan Wang, Qiuxu Teng, Megumi Murakami, Suresh V. Ambudkar, Fengfeng Ping, Zhesheng Chen

Front Biosci (Landmark Ed) Author manuscript; available in PMC 2023 Jun 12.

Published in final edited form as: Front Biosci (Landmark Ed). 2022 Jan 5; 27(1): 5. doi: 10.31083/j.fbl2701005

PMCID:: PMC10258814

Abstract Article PDF–1.1M

Select item 100058984.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 93653485.

Targeting the Ubiquitin–Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer

Safa Majeed, Mansi K. Aparnathi, Kevin C.J. Nixon, Vidhyasagar Venkatasubramanian, Fariha Rahman, Lifang Song, Jessica Weiss, Ranya Barayan, Vijithan Sugumar, Samir H. Barghout, Joel D. Pearson, Rod Bremner, Aaron D. Schimmer, Ming S. Tsao, Geoffrey Liu, Benjamin H. Lok

Clin Cancer Res. 2022 May 2; 28(9): 1966–1978. Published online 2022 Feb 11. doi: 10.1158/1078-0432.CCR-21-0344

PMCID:: PMC9365348

Abstract Article PDF–1.8M

Select item 89241366.

Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants

Christian Borgo, Claudio D’Amore, Valeria Capurro, Valeria Tomati, Elvira Sondo, Federico Cresta, Carlo Castellani, Nicoletta Pedemonte, Mauro Salvi

Cell Mol Life Sci. 2022 Apr; 79(4): 192. Published online 2022 Mar 16. doi: 10.1007/s00018-022-04215-3

PMCID:: PMC8924136

Abstract Article PDF–6.3M

Select item 83026797.

RETRACTED ARTICLE: GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death

Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang, Wanhong Zhang, Xiaomin Zhong, Yifeng Wang, Huan Li, Yang Shen, Changyong Wu, Rutong Yu, Mingshan Niu, Xuejiao Liu

Cell Death Dis. 2021 Aug; 12(8): 733. Published online 2021 Jul 23. doi: 10.1038/s41419-021-04023-w

Retraction in:: Cell Death Dis. 2024 Mar; 15(3): 188.

PMCID:: PMC8302679

Abstract Article

Select item 81782088.

SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243

Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa Jenkins, Shar-Yin N. Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier

Cancer Res. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Cancer Res. 2021 Jun 1; 81(11): 3067–3078. Published online 2021 Apr 16. doi: 10.1158/0008-5472.CAN-20-2694

PMCID:: PMC8178208

Abstract Article PDF–1.2M

Select item 80696919.

Direct Conjugation of NEDD8 to the N-Terminus of a Model Protein Can Induce Degradation

Kartikeya Vijayasimha, Marilyn Vo Tran, Amy L. Leestemaker-Palmer, Brian P. Dolan

Cells. 2021 Apr; 10(4): 854. Published online 2021 Apr 9. doi: 10.3390/cells10040854

PMCID:: PMC8069691

Abstract Article PDF–3.0M

Select item 802110110.

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer

JCI Insight. 2021 Mar 8; 6(5): e141518. Published online 2021 Mar 8. doi: 10.1172/jci.insight.141518

PMCID:: PMC8021101

Abstract Article PDF–1.6M

Select item 741684711.

Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes

Rebecca L. Swan, Luke L.K. Poh, Ian G. Cowell, Caroline A. Austin

Mol Pharmacol. 2020 Sep; 98(3): 222–233. Published online 2020 Sep. doi: 10.1124/mol.119.118893

PMCID:: PMC7416847

Abstract Article PDF–1.1M

Select item 680252212.

Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies

Zhe Sha, Tamara Blyszcz, Román González-Prieto, Alfred C. O. Vertegaal, Alfred L. Goldberg

J Biol Chem. 2019 Oct 18; 294(42): 15218–15234. Published online 2019 Jul 8. doi: 10.1074/jbc.RA119.009147

PMCID:: PMC6802522

Abstract Article PDF–4.3M

Select item 615607813.

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

Katherine A Donovan, Jian An, Radosław P Nowak, Jingting C Yuan, Emma C Fink, Bethany C Berry, Benjamin L Ebert, Eric S Fischer

eLife. 2018; 7: e38430. Published online 2018 Aug 1. doi: 10.7554/eLife.38430

PMCID:: PMC6156078

Abstract Article PDF–2.2M

Select item 542681714.

Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands

Jiajie Wei, Damien Zanker, Anthony R. Di Carluccio, Margery G. Smelkinson, Kazuyo Takeda, Mina O. Seedhom, Devin Dersh, James S. Gibbs, Ning Yang, Ajit Jadhav, Weisan Chen, Jonathan W. Yewdell

J Immunol. Author manuscript; available in PMC 2018 May 15.

Published in final edited form as: J Immunol. 2017 May 15; 198(10): 3835–3845. Published online 2017 Mar 31. doi: 10.4049/jimmunol.1602122

PMCID:: PMC5426817

Abstract Article PDF–1.3M

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