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Select item 113042341.

Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4

Lu Zhang, Zhengying Fang, Qingqing Zhu, Shumin Yang, Jia Fu, Zeguo Sun, Geming Lu, Chengguo Wei, Zhi Zhang, Kyung Lee, Yifei Zhong, Ruijie Liu, John Cijiang He

Adv Sci (Weinh) 2024 Aug; 11(29): 2309642. Published online 2024 May 30. doi: 10.1002/advs.202309642

PMCID:: PMC11304234

Abstract Article PDF–6.2M

Select item 111782322.

Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning

Yukitoshi Izumi, Kazuko A. O’Dell, Anil G. Cashikar, Steven M. Paul, Douglas F. Covey, Steven J. Mennerick, Charles F. Zorumski

PLoS One. 2024; 19(6): e0304481. Published online 2024 Jun 14. doi: 10.1371/journal.pone.0304481

PMCID:: PMC11178232

Abstract Article PDF–2.3M

Select item 110850303.

25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes

Tao Jiang, Yong Li

Braz J Med Biol Res. 2024; 57: e13299. Published online 2024 May 3. doi: 10.1590/1414-431X2024e13299

PMCID:: PMC11085030

Abstract Article PDF–1.7M

Select item 110341164.

25-hydroxycholesterol promotes proliferation and metastasis of lung adenocarcinoma cells by regulating ERβ/TNFRSF17 axis

Mengting He, Wenbo Jiang, Xingkai Li, Hongjin Liu, Hongsheng Ren, Yanliang Lin

BMC Cancer. 2024; 24: 505. Published online 2024 Apr 22. doi: 10.1186/s12885-024-12227-4

PMCID:: PMC11034116

Abstract Article PDF–25M

Select item 108230775.

25-Hydroxycholesterol in health and diseases

Cindy Nguyen, Julien Saint-Pol, Shiraz Dib, Caroline Pot, Fabien Gosselet

J Lipid Res. 2024 Jan; 65(1): 100486. Published online 2023 Dec 16. doi: 10.1016/j.jlr.2023.100486

PMCID:: PMC10823077

Abstract Article PDF–1.9M

Select item 107862406.

Differing Activities of Oxysterol-binding Protein (OSBP) Targeting Anti-Viral Compounds

Brett L. Roberts, Zachary C. Severance, Ryan C. Bensen, Anh T. Le, Cori A. Malinky, Evan M. Mettenbrink, Juan I. Nuñez, William J. Reddig, Earl L. Blewett, Anthony W. G. Burgett

Antiviral Res. Author manuscript; available in PMC 2024 Jan 12.

Published in final edited form as: Antiviral Res. 2019 Oct; 170: 104548. Published online 2019 Jul 2. doi: 10.1016/j.antiviral.2019.104548

PMCID:: PMC10786240

Abstract Article PDF–1.0M

Select item 107041227.

The Importance of “Negative” Results: Lipid Lessons in Coronavirus Biology

Sarah R. Leist, Jason R. Mock

Am J Respir Cell Mol Biol. 2023 Dec 1; 69(6): 610–611. Published online 2023 Sep 6. doi: 10.1165/rcmb.2023-0301ED

PMCID:: PMC10704122

Article PDF–529K

Select item 107041158.

Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice

Michael B. Fessler, Jennifer H. Madenspacher, Paul J. Baker, Kerry L. Hilligan, Andrea C. Bohrer, Ehydel Castro, Julie Meacham, Shih-Heng Chen, Reed F. Johnson, Jeffrey G. McDonald, Negin P. Martin, Charles J. Tucker, Debabrata Mahapatra, Mark Cesta, Katrin D. Mayer-Barber

Am J Respir Cell Mol Biol. 2023 Dec 1; 69(6): 638–648. Published online 2023 Aug 14. doi: 10.1165/rcmb.2023-0007OC

PMCID:: PMC10704115

Abstract Article PDF–1.6M

Select item 105339249.

25-hydroxycholesterol: an integrator of antiviral ability and signaling

Jialu Zhang, Yaohong Zhu, Xiaojia Wang, Jiufeng Wang

Front Immunol. 2023; 14: 1268104. Published online 2023 Sep 13. doi: 10.3389/fimmu.2023.1268104

PMCID:: PMC10533924

Abstract Article PDF–3.9M

Select item 1045785510.

Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro

Nitin Kamble, Vishwanatha R. A. P. Reddy, Ben Jackson, Faisal R. Anjum, Chidiebere C. Ubachukwu, Ajit Patil, Shahriar Behboudi

Viruses. 2023 Aug; 15(8): 1652. Published online 2023 Jul 29. doi: 10.3390/v15081652

PMCID:: PMC10457855

Abstract Article PDF–1.7M

Select item 1013215011.

25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

Jennifer H. Madenspacher, Eric D. Morrell, Jeffrey G. McDonald, Bonne M. Thompson, Yue Li, Konstantin G. Birukov, Anna A. Birukova, Renee D. Stapleton, Aidin Alejo, Peer W. Karmaus, Julie M. Meacham, Prashant Rai, Carmen Mikacenic, Mark M. Wurfel, Michael B. Fessler

JCI Insight. 2023 Apr 10; 8(7): e155448. Published online 2023 Apr 10. doi: 10.1172/jci.insight.155448

PMCID:: PMC10132150

Abstract Article PDF–1.0M

Select item 1006011512.

Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol

Anil G. Cashikar, Danira Toral-Rios, David Timm, Johnathan Romero, Michael Strickland, Justin M. Long, Xianlin Han, David M. Holtzman, Steven M. Paul

J Lipid Res. 2023 Apr; 64(4): 100350. Published online 2023 Feb 25. doi: 10.1016/j.jlr.2023.100350

PMCID:: PMC10060115

Abstract Article PDF–3.9M

Select item 992180313.

SGLT2 Inhibitors May Restore Endothelial Barrier Interrupted by 25-Hydroxycholesterol

Agnieszka Pawlos, Marlena Broncel, Ewelina Woźniak, Łukasz Markiewicz, Agnieszka Piastowska-Ciesielska, Paulina Gorzelak-Pabiś

Molecules. 2023 Feb; 28(3): 1112. Published online 2023 Jan 22. doi: 10.3390/molecules28031112

PMCID:: PMC9921803

Abstract Article PDF–2.4M

Select item 989228214.

Macrophage derived 25-hydroxycholesterol promotes vascular inflammation, atherogenesis and lesion remodeling

Alberto Canfrán-Duque, Noemi Rotllan, Xinbo Zhang, Irene Andrés-Blasco, Bonne M Thompson, Jonathan Sun, Nathan L Price, Marta Fernández-Fuertes, Joseph W. Fowler, Diego Gómez-Coronado, William C. Sessa, Chiara Giannarelli, Robert J Schneider, George Tellides, Jeffrey G McDonald, Carlos Fernández-Hernando, Yajaira Suárez

Circulation. Author manuscript; available in PMC 2024 Jan 31.

Published in final edited form as: Circulation. 2023 Jan 31; 147(5): 388–408. Published online 2022 Nov 23. doi: 10.1161/CIRCULATIONAHA.122.059062

PMCID:: PMC9892282

Abstract Article PDF–2.9M

Select item 984379615.

25-Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Involved in the Pathophysiological Process of Osteoporosis

YO-SEOB SEO, KYEONG-ROK KANG, HYANGI LIM, JEONG-YEON SEO, DO KYUNG KIM, JAE-SUNG KIM

In Vivo. 2023 Jan-Feb; 37(1): 204–217. Published online 2023 Jan 3. doi: 10.21873/invivo.13069

PMCID:: PMC9843796

Abstract Article PDF–11M

Select item 976979816.

25-Hydroxycholesterol Mediates Cholesterol Metabolism to Restrict Porcine Deltacoronavirus Infection via Suppression of Transforming Growth Factor β1

Jialu Zhang, Guanghui Yang, Xuefei Wang, Yaohong Zhu, Jiufeng Wang

Microbiol Spectr. 2022 Nov-Dec; 10(6): e02198-22. Published online 2022 Oct 31. doi: 10.1128/spectrum.02198-22

PMCID:: PMC9769798

Abstract Article PDF–3.9M

Select item 963704917.

Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019

Takumi Asano, Tetsuji Wakabayashi, Yasuyuki Kondo, Kenta Okada, Daisuke Yamamuro, Yukiko Koga, Kiyonori Oka, Momoe Sakurai, Nagisa Sawayama, Manabu Takahashi, Hiroaki Okazaki, Ken Ebihara, Kensuke Minami, Yuji Morisawa, Shuji Hatakeyama, Masami Matsumura, Shun Ishibashi

J Clin Lipidol. 2023 January-February; 17(1): 78–86. Published online 2022 Nov 6. doi: 10.1016/j.jacl.2022.10.012

PMCID:: PMC9637049

Abstract Article PDF–1.0M

Select item 927241118.

Oxysterols protect bovine endometrial cells against pore-forming toxins from pathogenic bacteria

Thomas J. R. Ormsby, Sian E. Owens, Anthony D. Horlock, Daphne Davies, William J. Griffiths, Yuqin Wang, James G. Cronin, John J. Bromfield, Iain M. Sheldon

FASEB J. Author manuscript; available in PMC 2022 Jul 11.

Published in final edited form as: FASEB J. 2021 Oct; 35(10): e21889. doi: 10.1096/fj.202100036R

PMCID:: PMC9272411

Abstract Article PDF–2.9M

Select item 920126519.

25-Hydroxycholesterol as a Signaling Molecule of the Nervous System

Ulia G. Odnoshivkina, Eva A. Kuznetsova, Alexey M. Petrov

Biochemistry (Mosc) 2022; 87(6): 524–537. Published online 2022 Jun 16. doi: 10.1134/S0006297922060049

PMCID:: PMC9201265

Abstract Article PDF–1.5M

Select item 911916720.

Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins

Shijie Mao, Jie Ren, Ying Xu, Jidong Lin, Chuqiao Pan, Yu Meng, Ning Xu

Eur J Pharmacol. 2022 Jul 5; 926: 175033. Published online 2022 May 19. doi: 10.1016/j.ejphar.2022.175033

PMCID:: PMC9119167

Abstract Article PDF–5.1M

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