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Select item 104324961.

Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model

Tim Kaden, Katja Graf, Knut Rennert, Ruoya Li, Alexander S. Mosig, Martin Raasch

Sci Rep. 2023; 13: 13338. Published online 2023 Aug 16. doi: 10.1038/s41598-023-40004-z

PMCID:: PMC10432496

Abstract Article PDF–5.6M

Select item 74474782.

Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis

Ji-gan Wang, Hai-Rong Cui, Yi-sen Hu, Hua-Bo Tang

Medicine (Baltimore) 2020 Aug 21; 99(34): e21860. Published online 2020 Aug 21. doi: 10.1097/MD.0000000000021860

PMCID:: PMC7447478

Abstract Article PDF–1.2M

Select item 58120393.

Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

Charu Garg, Joon Ho Seo, Jayalakshmi Ramachandran, Ji Meng Loh, Frances Calderon, Jorge E. Contreras

J Neuroinflammation. 2018; 15: 42. Published online 2018 Feb 13. doi: 10.1186/s12974-018-1069-9

PMCID:: PMC5812039

Abstract Article PDF–2.0M

Select item 56734804.

Trovafloxacin acyl-glucuronide induces chemokine (C-X-C motif) ligand 2 in HepG2 cells

Ryo Mitsugi, Kyohei Sumida, Yoshiko Fujie, Robert H. Tukey, Tomoo Itoh, Ryoichi Fujiwara

Biol Pharm Bull. Author manuscript; available in PMC 2017 Nov 6.

Published in final edited form as: Biol Pharm Bull. 2016; 39(10): 1604–1610. doi: 10.1248/bpb.b16-00195

PMCID:: PMC5673480

Abstract Article PDF–794K

Select item 52902765.

A quantized mechanism for activation of pannexin channels

Yu-Hsin Chiu, Xueyao Jin, Christopher B. Medina, Susan A. Leonhardt, Volker Kiessling, Brad C. Bennett, Shaofang Shu, Lukas K. Tamm, Mark Yeager, Kodi S. Ravichandran, Douglas A. Bayliss

Nat Commun. 2017; 8: 14324. Published online 2017 Jan 30. doi: 10.1038/ncomms14324

PMCID:: PMC5290276

Abstract Article PDF–4.5M

Select item 49367116.

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

Deborah G. Nguyen, Juergen Funk, Justin B. Robbins, Candace Crogan-Grundy, Sharon C. Presnell, Thomas Singer, Adrian B. Roth

PLoS One. 2016; 11(7): e0158674. Published online 2016 Jul 7. doi: 10.1371/journal.pone.0158674

PMCID:: PMC4936711

Abstract Article PDF–4.9M

Select item 45923557.

Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library

Shiuan Chen, Jui-Hua Hsieh, Ruili Huang, Srilatha Sakamuru, Li-Yu Hsin, Menghang Xia, Keith R. Shockley, Scott Auerbach, Noriko Kanaya, Hannah Lu, Daniel Svoboda, Kristine L. Witt, B. Alex Merrick, Christina T. Teng, Raymond R. Tice

Toxicol Sci. 2015 Oct; 147(2): 446–457. Published online 2015 Jul 3. doi: 10.1093/toxsci/kfv141

PMCID:: PMC4592355

Abstract Article PDF–921K

Select item 44452418.

Trovafloxacin-induced Replication Stress Sensitizes HepG2 Cells to Tumor Necrosis Factor-alpha-induced Cytotoxicity Mediated by Extracellular Signal-regulated Kinase and Ataxia Telangiectasia and Rad3-related

Kevin M. Beggs, Ashley R. Maiuri, Aaron M. Fullerton, Kyle L. Poulsen, Anna B. Breier, Patricia E. Ganey, Robert A. Roth

Toxicology. Author manuscript; available in PMC 2016 May 4.

Published in final edited form as: Toxicology. 2015 May 4; 331: 35–46. Published online 2015 Mar 5. doi: 10.1016/j.tox.2015.03.002

PMCID:: PMC4445241

Abstract Article PDF–4.8M

Select item 43315239.

Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium

Keiyu Oshida, Naresh Vasani, Russell S. Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M. Aleksunes, Curtis Klaassen, J. Christopher Corton

PLoS One. 2015; 10(2): e0112655. Published online 2015 Feb 17. doi: 10.1371/journal.pone.0112655

Correction in:: PLoS One. 2015; 10(4): e0124224.

PMCID:: PMC4331523

Abstract Article PDF–4.2M

Select item 407899110.

Unexpected link between an antibiotic, pannexin channels, and apoptosis

Ivan K. H. Poon, Yu-Hsin Chiu, Allison J. Armstrong, Jason M. Kinchen, Ignacio J. Juncadella, Douglas A. Bayliss, Kodi S. Ravichandran

Nature. Author manuscript; available in PMC 2014 Sep 20.

Published in final edited form as: Nature. 2014 Mar 20; 507(7492): 329–334. Published online 2014 Mar 12. doi: 10.1038/nature13147

PMCID:: PMC4078991

Abstract Article PDF–2.0M

Select item 405626911.

Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response

Kyle L. Poulsen, Jesus Olivero-Verbel, Kevin M. Beggs, Patricia E. Ganey, Robert A. Roth

J Pharmacol Exp Ther. 2014 Jul; 350(1): 164–170. Published online 2014 Jul. doi: 10.1124/jpet.114.214189

PMCID:: PMC4056269

Abstract Article PDF–688K

Select item 398980412.

Trovafloxacin Potentiation of Lipopolysaccharide-Induced Tumor Necrosis Factor Release from RAW 264.7 Cells Requires Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase

Kyle L. Poulsen, Ryan P. Albee, Patricia E. Ganey, Robert A. Roth

J Pharmacol Exp Ther. 2014 May; 349(2): 185–191. Published online 2014 May. doi: 10.1124/jpet.113.211276

PMCID:: PMC3989804

Abstract Article PDF–494K

Select item 387192913.

Molecular Mechanisms of Hepatocellular Apoptosis Induced by Trovafloxacin-Tumor Necrosis Factor-alpha Interaction

Kevin M. Beggs, Aaron M. Fullerton, Kazuhisa Miyakawa, Patricia E. Ganey, Robert A. Roth

Toxicol Sci. 2014 Jan; 137(1): 91–101. Published online 2013 Oct 4. doi: 10.1093/toxsci/kft226

PMCID:: PMC3871929

Abstract Article PDF–7.2M

Select item 353535114.

Multi-cell type human liver microtissues for hepatotoxicity testing

S. Messner, I. Agarkova, W. Moritz, J. M. Kelm

Arch Toxicol. 2013; 87(1): 209–213. Published online 2012 Nov 11. doi: 10.1007/s00204-012-0968-2

PMCID:: PMC3535351

Abstract Article PDF–420K

Select item 337250115.

Genetics of Microenvironmental Sensitivity of Body Weight in Rainbow Trout (Oncorhynchus mykiss) Selected for Improved Growth

Matti Janhunen, Antti Kause, Harri Vehviläinen, Otso Järvisalo

PLoS One. 2012; 7(6): e38766. Published online 2012 Jun 11. doi: 10.1371/journal.pone.0038766

PMCID:: PMC3372501

Abstract Article PDF–153K

Select item 337147916.

Uncontrolled penile erection and increased sexual desire with intravenous moxifloxacin

Abdulkadir Kucukbayrak, Zulkuf Perdeci, Zeynep Seckin Kucukbayrak, Ersin Günay

Indian J Pharmacol. 2012 May-Jun; 44(3): 426–427. doi: 10.4103/0253-7613.96359

PMCID:: PMC3371479

Article

Select item 335640317.

Activity Patterns during Food Provisioning Are Affected by Artificial Light in Free Living Great Tits (Parus major)

Mieke Titulaer, Kamiel Spoelstra, Cynthia Y. M. J. G. Lange, Marcel E. Visser

PLoS One. 2012; 7(5): e37377. Published online 2012 May 18. doi: 10.1371/journal.pone.0037377

PMCID:: PMC3356403

Abstract Article PDF–95K

Select item 333533718.

High-Performance Liquid Chromatography Assay for Moxifloxacin in Brain Tissue and Plasma: Validation in a Pharmacokinetic Study in a Murine Model of Cerebral Listeriosis

Renaud Respaud, Solene Grayo, Eric Singlas, Sophie Dubouch, Alban Le Monnier, Marie-Catherine Lott

J Anal Methods Chem. 2012; 2012: 436349. Published online 2012 Mar 14. doi: 10.1155/2012/436349

PMCID:: PMC3335337

Abstract Article PDF–795K

Select item 332276019.

Quinolone Safety and Efficacy More Important than Potency

Richard Frothingham

Emerg Infect Dis. 2004 Jan; 10(1): 156–157. doi: 10.3201/eid1001.030307

PMCID:: PMC3322760

Article PDF–25K

Select item 332275520.

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from Pigs to Humans, Taiwan

Po-Ren Hsueh, Lee-Jene Teng, Sung-Pin Tseng, Chao-Fu Chang, Jen-Hsien Wan, Jing-Jou Yan, Chun-Ming Lee, Yin-Ching Chuang, Wen-Kuei Huang, Dine Yang, Jainn-Ming Shyr, Kwok-Woon Yu, Li-Shin Wang, Jang-Jih Lu, Wen-Chien Ko, Jiunn-Jong Wu, Feng-Yee Chang, Yi-Chueh Yang, Yeu-Jun Lau, Yung-Ching Liu, Cheng-Yi Liu, Shen-Wu Ho, Kwen-Tay Luh

Emerg Infect Dis. 2004 Jan; 10(1): 60–68. doi: 10.3201/eid1001.030171