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Select item 112833501.

Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial

J. Downs, P. Jacoby, N. Specchio, H. Cross, S. Amin, N. Bahi-Buisson, R. Rajaraman, B. Suter, O. Devinsky, A. Aimetti, G. Busse, H.E. Olson, S. Demarest, T.A. Benke, E. Pestana-Knight

Eur J Paediatr Neurol. Author manuscript; available in PMC 2024 Jul 28.

Published in final edited form as: Eur J Paediatr Neurol. 2024 Jul; 51: 140–146. Published online 2024 Jun 17. doi: 10.1016/j.ejpn.2024.06.005

PMCID:: PMC11283350

Abstract Article PDF–803K

Select item 111992132.

The efficacy and safety of Zuranolone for treatment of depression: A systematic review and meta-analysis

Aya M. Fayoud, Hisham Ahmed Orebi, Iman Abdelhady Elshnoudy, Mai Alaaeldin Temraz Elsebaie, Mariam Mahmoud Mohamed Elewidi, Hamdy Khaled Sabra

Psychopharmacology (Berl) 2024; 241(7): 1299–1317. Published online 2024 May 28. doi: 10.1007/s00213-024-06611-y

Correction in:: Psychopharmacology (Berl). 2024; 241(9): 1937.

PMCID:: PMC11199213

Abstract Article PDF–953K

Select item 111782323.

Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning

Yukitoshi Izumi, Kazuko A. O’Dell, Anil G. Cashikar, Steven M. Paul, Douglas F. Covey, Steven J. Mennerick, Charles F. Zorumski

PLoS One. 2024; 19(6): e0304481. Published online 2024 Jun 14. doi: 10.1371/journal.pone.0304481

PMCID:: PMC11178232

Abstract Article PDF–2.3M

Select item 111388714.

Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks

C. Patte-Mensah, S. Li, A. G. Mensah-Nyagan

Cell Mol Life Sci. 2004 Aug; 61(17): 2274–2284. doi: 10.1007/s00018-004-4235-4

PMCID:: PMC11138871

Abstract Article PDF–459K

Select item 111157435.

Cellular and functional evidence for a protective action of neurosteroids against vincristine chemotherapy-induced painful neuropathy

Laurence Meyer, Christine Patte-Mensah, Omar Taleb, Ayikoe Guy Mensah-Nyagan

Cell Mol Life Sci. 2010 Sep; 67(17): 3017–3034. Published online 2010 Apr 30. doi: 10.1007/s00018-010-0372-0

PMCID:: PMC11115743

Abstract Article PDF–964K

Select item 110919136.

Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis

Aidan Evans-Strong, Najah Walton, Katrina Blandino, Abigail T. C. Roper, S. Tiffany Donaldson, Mike Lewis, Jamie Maguire

J Neuroendocrinol. Author manuscript; available in PMC 2024 May 14.

Published in final edited form as: J Neuroendocrinol. 2024 Apr; 36(4): e13378. Published online 2024 Mar 14. doi: 10.1111/jne.13378

PMCID:: PMC11091913

Abstract Article PDF–1.0M

Select item 110485617.

Neurosteroid Modulation of Synaptic and Extrasynaptic GABA_A Receptors of the Mouse Nucleus Accumbens

Scott J. Mitchell, Grant D. Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J. Martin, Jerome D. Swinny, Louise Kelly, John R. Atack, Michael Paradowski, Jeremy J. Lambert

Biomolecules. 2024 Apr; 14(4): 460. Published online 2024 Apr 9. doi: 10.3390/biom14040460

PMCID:: PMC11048561

Abstract Article PDF–3.3M

Select item 110482628.

Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs

Irene Vuu, Edward E. Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E. Leppik, Michael A. Rogawski, Gregory A. Worrell, Vaclav Kremen, James C. Cloyd, Lisa D. Coles

J Pharmacol Exp Ther. 2022 Feb; 380(2): 104–113. Published online 2022 Feb. doi: 10.1124/jpet.121.000736

PMCID:: PMC11048262

Abstract Article PDF–1.6M

Select item 109549909.

Neurosteroids and their potential as a safer class of general anesthetics

Hiroki Tateiwa, Alex S. Evers

J Anesth. 2024; 38(2): 261–274. Published online 2024 Jan 22. doi: 10.1007/s00540-023-03291-4

PMCID:: PMC10954990

Abstract Article PDF–1.2M

Select item 1094448410.

Local effect of allopregnanolone in rat ovarian steroidogenesis, follicular and corpora lutea development

Antonella Rosario Ramona Cáceres, Daniela Alejandra Cardone, María de los Ángeles Sanhueza, Ignacio Manuel Bosch, Fernando Darío Cuello-Carrión, Graciela Beatriz Rodriguez, Leopoldina Scotti, Fernanda Parborell, Julia Halperin, Myriam Raquel Laconi

Sci Rep. 2024; 14: 6402. Published online 2024 Mar 16. doi: 10.1038/s41598-024-57102-1

PMCID:: PMC10944484

Abstract Article PDF–10M

Select item 1094444711.

Cardiovascular responses of adult male Sprague–Dawley rats following acute organophosphate intoxication and post-exposure treatment with midazolam with or without allopregnanolone

Shiyue Pan, Donald A. Bruun, Pamela J. Lein, Chao-Yin Chen

Arch Toxicol. 2024; 98(4): 1177–1189. Published online 2024 Feb 2. doi: 10.1007/s00204-023-03679-x

PMCID:: PMC10944447

Abstract Article PDF–3.3M

Select item 1080176912.

Evaluation of Midazolam-Ketamine-Allopregnanolone Combination Therapy against Cholinergic-Induced Status Epilepticus in Rats

Donna A. Nguyen, Michael F. Stone, Caroline R. Schultz, Marcio de Araujo Furtado, Jerome Niquet, Claude G. Wasterlain, Lucille A. Lumley

J Pharmacol Exp Ther. 2024 Feb; 388(2): 376–385. Published online 2024 Feb. doi: 10.1124/jpet.123.001784

PMCID:: PMC10801769

Abstract Article PDF–2.6M

Select item 1080176213.

Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic

Doodipala Samba Reddy

J Pharmacol Exp Ther. 2024 Feb; 388(2): 273–300. Published online 2024 Feb. doi: 10.1124/jpet.123.001816

PMCID:: PMC10801762

Abstract Article PDF–1.8M

Select item 1078666014.

Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor

Meiyue Dong, Yanyan Wang, Ping Li, Zinuo Chen, Varada Anirudhan, Qinghua Cui, Lijun Rong, Ruikun Du

Virol Sin. 2023 Dec; 38(6): 931–939. Published online 2023 Sep 22. doi: 10.1016/j.virs.2023.09.003

PMCID:: PMC10786660

Abstract Article PDF–2.4M

Select item 1078500715.

Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms

Chian-Ru Chern, Marcela Lauková, Antonia Schonwald, Eva Kudová, Hana Chodounská, Chian-Jiang Chern, Michael P. Shakarjian, Jana Velíšková, Libor Velíšek

Pharmacol Rep. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Pharmacol Rep. 2023 Feb; 75(1): 177–188. Published online 2022 Nov 23. doi: 10.1007/s43440-022-00437-1