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Items: 1 to 20 of 32

1.
Enhancing the immunogenicity of Wilms tumor 1 epitope in mesothelioma cells with immunoproteasome inhibitors
Masaki Ito, Shigeo Koido, Takeo Iwamoto, Soyoko Morimoto, Fumihiro Fujiki, Haruo Sugiyama, Saki Matsumoto, Clara Effenberger, Kazuma Kiyotani, Kiyotaka Shiba
PLoS One. 2024; 19(8): e0308330. Published online 2024 Aug 8. doi: 10.1371/journal.pone.0308330
PMCID:
PMC11309442
AbstractArticlePDF–2.4M
2.
Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation
Nicolás Albornoz, Javiera Álvarez-Indo, Adely de la Peña, Eloisa Arias-Muñoz, Alanis Coca, Fabián Segovia-Miranda, Bredford Kerr, Mauricio Budini, Alfredo Criollo, María A. García-Robles, Eugenia Morselli, Andrea Soza, Patricia V. Burgos
J Neuroinflammation. 2024; 21: 191. Published online 2024 Aug 2. doi: 10.1186/s12974-024-03154-z
PMCID:
PMC11297766
AbstractArticlePDF–5.6M
3.
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
Frank H. Schaftenaar, Andrea D. van Dam, Gerjan de Bruin, Marie A.C. Depuydt, Jill de Mol, Jacob Amersfoort, Hidde Douna, Menno Meijer, Mara J. Kröner, Peter J. van Santbrink, Mireia N.A. Bernabé Kleijn, Gijs H.M. van Puijvelde, Bogdan I. Florea, Bram Slütter, Amanda C. Foks, Ilze Bot, Patrick C.N. Rensen, Johan Kuiper
Arterioscler Thromb Vasc Biol. 2024 Jun; 44(6): 1346–1364. Published online 2024 Apr 25. doi: 10.1161/ATVBAHA.123.319701
PMCID:
PMC11188635
AbstractArticlePDF–2.9M
4.
Inhibition of immunoproteasome subunit low molecular mass polypeptide 7 with ONX-0914 improves hypoxic-ischemic brain damage via PI3K/Akt signaling
Yue Zhou, Zhixian Gou, Lin Huang, Yang Fan, Feng Zhang, Liqun Lu
Neuroreport. 2021 Oct 6; 32(14): 1206–1215. Published online 2021 Aug 16. doi: 10.1097/WNR.0000000000001715
PMCID:
PMC8389355
AbstractArticlePDF–1.4M
5.
Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods
Giulia Culletta, Maria Zappalà, Roberta Ettari, Anna Maria Almerico, Marco Tutone
Molecules. 2021 Jul; 26(13): 4046. Published online 2021 Jul 2. doi: 10.3390/molecules26134046
PMCID:
PMC8271555
AbstractArticlePDF–3.6M
6.
Immunoproteasome Activity and Content Determine Hematopoietic Cell Sensitivity to ONX-0914 and to the Infection of Cells with Lentiviruses
Elmira Vagapova, Alexander Burov, Daria Spasskaya, Timofey Lebedev, Tatiana Astakhova, Pavel Spirin, Vladimir Prassolov, Vadim Karpov, Alexey Morozov
Cells. 2021 May; 10(5): 1185. Published online 2021 May 12. doi: 10.3390/cells10051185
PMCID:
PMC8150886
AbstractArticlePDF–3.0M
7.
Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL–AF4 fusion protein
Tyler W. Jenkins, Sondra L. Downey-Kopyscinski, Jennifer L. Fields, Gilbert J. Rahme, William C. Colley, Mark A. Israel, Andrey V. Maksimenko, Steven N. Fiering, Alexei F. Kisselev
Sci Rep. 2021; 11: 10883. Published online 2021 May 25. doi: 10.1038/s41598-021-90451-9
PMCID:
PMC8149845
AbstractArticlePDF–1.5M
8.
Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
Sheng-hong Du, Yu-jiao Xiang, Lu Liu, Mu Nie, Yu Hou, Ling Wang, Ban-ban Li, Miao Xu, Qing-liang Teng, Jun Peng, Ming Hou, Yan Shi
Front Immunol. 2020; 11: 603278. Published online 2021 Jan 20. doi: 10.3389/fimmu.2020.603278
PMCID:
PMC7855704
AbstractArticlePDF–1.6M
9.
Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection
Carl Christoph Goetzke, Nadine Althof, Hannah Louise Neumaier, Arndt Heuser, Ziya Kaya, Meike Kespohl, Karin Klingel, Antje Beling
Basic Res Cardiol. 2021; 116(1): 7. Published online 2021 Feb 1. doi: 10.1007/s00395-021-00848-w
PMCID:
PMC7851025
AbstractArticlePDF–8.1M
10.
Proteasome Inhibitors Diminish c-Met Expression and Induce Cell Death in Non-Small Cell Lung Cancer Cells
Yanhui Li, Su Dong, Arya Tamaskar, Heather Wang, Jing Zhao, Haichun Ma, Yutong Zhao
Oncol Res. 2020; 28(5): 497–507. Published online 2020 Dec 10. doi: 10.3727/096504020X15929939001042
PMCID:
PMC7751221
AbstractArticlePDF–20M
11.
Short-Term ONX-0914 Administration: Performance and Muscle Phenotype in Mdx Mice
Dongmin Kwak, Guoxian Wei, LaDora V. Thompson, Jong-Hee Kim
Int J Environ Res Public Health. 2020 Jul; 17(14): 5211. Published online 2020 Jul 19. doi: 10.3390/ijerph17145211
PMCID:
PMC7399807
AbstractArticlePDF–980K
12.
PR-957对A1反应性星形胶质细胞形成的影响
戴 淑馨, 王 宇, 林 丽芳, 袁 天明
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Nov 25; 21(11): 1110–1115. Chinese. doi: 10.7499/j.issn.1008-8830.2019.11.011
PMCID:
PMC7389308
AbstractArticlePDF–1.4M
13.
ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in CoxsackievirusB3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage
Hannah Louise Neumaier, Shelly Harel, Karin Klingel, Ziya Kaya, Arnd Heuser, Meike Kespohl, Antje Beling
Cells. 2020 May; 9(5): 1093. Published online 2020 Apr 28. doi: 10.3390/cells9051093
PMCID:
PMC7290815
AbstractArticlePDF–6.3M
14.
The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology
Simon D. Harding, Elena Faccenda, Christopher Southan, Adam J. Pawson, Pasquale Maffia, Stephen P. H. Alexander, Anthony P. Davenport, Doriano Fabbro, Francesca Levi‐Schaffer, Michael Spedding, Jamie A. Davies
Immunology. 2020 May; 160(1): 10–23. Published online 2020 Mar 2. doi: 10.1111/imm.13175
PMCID:
PMC7160657
AbstractArticlePDF–4.1M
15.
Immunoproteasomes as a novel antiviral mechanism in rhinovirus-infected airways
Kris Genelyn Dimasuay, Amelia Sanchez, Niccolette Schaefer, Jorge Polanco, Deborah A. Ferrington, Hong Wei Chu
Clin Sci (Lond) Author manuscript; available in PMC 2020 Mar 31.
Published in final edited form as: Clin Sci (Lond). 2018 Aug 16; 132(15): 1711–1723. Published online 2018 Aug 16. doi: 10.1042/CS20180337
PMCID:
PMC7105891
AbstractArticlePDF–1.2M
16.
Synthesis and Application of an Activity-Based Peptide-Peptoid Hybrid Probe for the Immunoproteasome
Breanna L. Zerfas, Darci J. Trader
Curr Protoc Chem Biol. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Curr Protoc Chem Biol. 2019 Dec; 11(4): e76. doi: 10.1002/cpch.76
PMCID:
PMC6927525
AbstractArticlePDF–1.0M
17.
Inhibiting the immunoproteasome's β5i catalytic activity affects human peripheral blood‐derived immune cell viability
Katrien Pletinckx, Silke Vaßen, Ilka Schlusche, Sonja Nordhoff, Gregor Bahrenberg, Torsten R. Dunkern
Pharmacol Res Perspect. 2019 Aug; 7(4): e00482. Published online 2019 Jun 18. doi: 10.1002/prp2.482
PMCID:
PMC6581949
AbstractArticlePDF–2.3M
18.
Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis
Christian Schmidt, Thilo Berger, Marcus Groettrup, Michael Basler
Front Immunol. 2018; 9: 2386. Published online 2018 Oct 26. doi: 10.3389/fimmu.2018.02386
PMCID:
PMC6212513
AbstractArticlePDF–3.0M
19.
An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors
Sondra Downey-Kopyscinski, Ellen W. Daily, Marc Gautier, Ananta Bhatt, Bogdan I. Florea, Constantine S. Mitsiades, Paul G. Richardson, Christoph Driessen, Herman S. Overkleeft, Alexei F. Kisselev
Blood Adv. 2018 Oct 9; 2(19): 2443–2451. Published online 2018 Sep 28. doi: 10.1182/bloodadvances.2018016360
PMCID:
PMC6177641
AbstractArticlePDF–1.3M
20.
PR‐957 mediates neuroprotection by inhibiting Th17 differentiation and modulating cytokine production in a mouse model of ischaemic stroke
Y. Guo, X. Chen, D. Li, H. Liu, Y. Ding, R. Han, Y. Shi, X. Ma
Clin Exp Immunol. 2018 Aug; 193(2): 194–206. Published online 2018 Apr 23. doi: 10.1111/cei.13132
PMCID:
PMC6046491
AbstractArticlePDF–832K

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