PMC Articles for PubChem Compound (Select 135567102) - PMC

Select item 105992871.

High In Vitro and In Vivo Activity of BI-847325, a Dual MEK/Aurora Kinase Inhibitor, in Human Solid and Hematologic Cancer Models

Vincent Vuaroqueaux, Alexandra Musch, Anne-Lise Peille, Gerhard Kelter, Loreen Weichert, Thomas Metz, Hans R. Hendriks, Heinz-Herbert Fiebig

Cancer Res Commun. 2023 Oct; 3(10): 2170–2181. Published online 2023 Oct 25. doi: 10.1158/2767-9764.CRC-22-0221

PMCID:: PMC10599287

Abstract Article PDF–6.8M

Select item 92831752.

GANT61/BI-847325 combination: a new hope in lung cancer treatment

Abdel Halim M. El-Kishky, Nermine Moussa, Maged W. Helmy, Medhat Haroun

Med Oncol. 2022; 39(10): 144. Published online 2022 Jul 14. doi: 10.1007/s12032-022-01738-4

PMCID:: PMC9283175

Abstract Article PDF–1.2M

Select item 65929943.

Transcript-level regulation of MALAT1-mediated cell cycle and apoptosis genes using dual MEK/Aurora kinase inhibitor “BI-847325” on anaplastic thyroid carcinoma

Hilda Samimi, Vahid Haghpanah, Shiva Irani, Ehsan Arefian, Alireza Naderi Sohi, Parviz Fallah, Masoud Soleimani

Daru. 2019 Jun; 27(1): 1–7. Published online 2019 May 10. doi: 10.1007/s40199-018-0231-3

PMCID:: PMC6592994

Abstract Article PDF–705K

Select item 65426684.

The target landscape of clinical kinase drugs

Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger, Zhixiang Wu, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne-Kathrin Garz, Bjoern-Oliver Gohlke, Daniel Paul Zolg, Gian Kayser, Tonu Vooder, Robert Preissner, Hannes Hahne, Neeme Tonisson, Karl Kramer, Katharina Goetze, Florian Bassermann, Judith Schlegl, Hans-Christian Ehrlich, Stephan Aiche, Axel Walch, Philipp A. Greif, Sabine Schneider, Eduard Rudolf Felder, Juergen Ruland, Guillaume Medard, Irmela Jeremias, Karsten Spiekermann, Bernhard Kuster

Science. Author manuscript; available in PMC 2019 May 30.

Published in final edited form as: Science. 2017 Dec 1; 358(6367): eaan4368. doi: 10.1126/science.aan4368

PMCID:: PMC6542668

Abstract Article PDF–2.5M

Select item 44584625.

The novel ATP-competitive MEK/Aurora kinase inhibitor BI-847325 overcomes acquired BRAF inhibitor resistance through suppression of Mcl-1 and MEK expression

Manali S. Phadke, Patrizia Sini, Keiran S. M. Smalley

Mol Cancer Ther. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Mol Cancer Ther. 2015 Jun; 14(6): 1354–1364. Published online 2015 Apr 14. doi: 10.1158/1535-7163.MCT-14-0832

PMCID:: PMC4458462

Abstract Article PDF–3.6M

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