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Select item 113171271.

Structure-based characterization and compound identification of the wild-type THF class-II riboswitch

Chunyan Li, Xiaochen Xu, Zhi Geng, Luqian Zheng, Qianqian Song, Xin Shen, Jingjing Wu, Jin zhao, Hongcheng Li, Mengqi He, Xiaoqing Tai, Long Zhang, Jinbiao Ma, Yuhui Dong, Aiming Ren

Nucleic Acids Res. 2024 Aug 12; 52(14): 8454–8465. Published online 2024 May 20. doi: 10.1093/nar/gkae377

PMCID:: PMC11317127

Abstract Article PDF–4.4M

Select item 91802082.

The Second Class of Tetrahydrofolate (THF-II) Riboswitches Recognizes the Tetrahydrofolic Acid Ligand via Local Conformation Changes

Minmin Zhang, Guangfeng Liu, Yunlong Zhang, Ting Chen, Shanshan Feng, Rujie Cai, Changrui Lu

Int J Mol Sci. 2022 Jun; 23(11): 5903. Published online 2022 May 25. doi: 10.3390/ijms23115903

PMCID:: PMC9180208

Abstract Article PDF–2.2M

Select item 88794133.

Role of active site loop dynamics in mediating ligand release from E. coli dihydrofolate reductase

Amrinder Singh, Robert Bryn Fenwick, H. Jane Dyson, Peter E. Wright

Biochemistry. Author manuscript; available in PMC 2022 Sep 7.

Published in final edited form as: Biochemistry. 2021 Sep 7; 60(35): 2663–2671. Published online 2021 Aug 24. doi: 10.1021/acs.biochem.1c00461

PMCID:: PMC8879413

Abstract Article PDF–1.1M

Select item 86082854.

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Mark R. Sullivan, Alicia M. Darnell, Montana F. Reilly, Tenzin Kunchok, Lena Joesch-Cohen, Daniel Rosenberg, Ahmed Ali, Matthew G. Rees, Jennifer A. Roth, Caroline A. Lewis, Matthew G. Vander Heiden

Nat Metab. Author manuscript; available in PMC 2022 May 18.

Published in final edited form as: Nat Metab. 2021 Nov; 3(11): 1500–1511. Published online 2021 Nov 18. doi: 10.1038/s42255-021-00486-5

PMCID:: PMC8608285

Abstract Article PDF–1.6M

Select item 76546195.

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

Natalia I. Krupenko, Jaspreet Sharma, Peter Pediaditakis, Kristi L. Helke, Madeline S. Hall, Xiuxia Du, Susan Sumner, Sergey A. Krupenko

Hum Genomics. 2020; 14: 41. Published online 2020 Nov 9. doi: 10.1186/s40246-020-00291-3

PMCID:: PMC7654619

Abstract Article PDF–3.3M

Select item 72517596.

DJ-1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer

Weimin Wang, Haibo Wang, Liangliang Xiang, Tengyang Ni, Feng Jin, Jianliang Deng, Yunlei Zhang, Ishikawa Shintaro, Yan Zhou, Yanqing Liu

Oncol Rep. 2020 Jul; 44(1): 77–90. Published online 2020 Apr 23. doi: 10.3892/or.2020.7593

PMCID:: PMC7251759

Abstract Article PDF–1.7M

Select item 71547627.

Structures in Tetrahydrofolate Methylation in Desulfitobacterial Glycine Betaine Metabolism at Atomic Resolution

Thomas Badmann, Prof. Dr. Michael Groll

Chembiochem. 2020 Mar 16; 21(6): 776–779. Published online 2019 Nov 18. doi: 10.1002/cbic.201900515

PMCID:: PMC7154762

Abstract Article PDF–2.1M

Select item 70762208.

Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode

David A. Korasick, Pramod K. Kandoth, John J. Tanner, Melissa G. Mitchum, Lesa J. Beamer

J Biol Chem. 2020 Mar 13; 295(11): 3708–3718. Published online 2020 Feb 2. doi: 10.1074/jbc.RA119.012256

PMCID:: PMC7076220

Abstract Article PDF–2.5M

Select item 67977079.

Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver

Natalia I. Krupenko, Jaspreet Sharma, Peter Pediaditakis, Baharan Fekry, Kristi L. Helke, Xiuxia Du, Susan Sumner, Sergey A. Krupenko

Sci Rep. 2019; 9: 14937. Published online 2019 Oct 17. doi: 10.1038/s41598-019-51397-1

PMCID:: PMC6797707

Abstract Article PDF–3.9M

Select item 674646510.

MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation

Jonathan W. Picking, Edward J. Behrman, Liwen Zhang, Joseph A. Krzycki

J Biol Chem. 2019 Sep 13; 294(37): 13697–13707. Published online 2019 Jul 24. doi: 10.1074/jbc.RA119.009886

PMCID:: PMC6746465

Abstract Article PDF–1.1M

Select item 668929711.

The Properties of 5-Methyltetrahydrofolate Dehydrogenase (MetF1) and Its Role in the Tetrahydrofolate-Dependent Dicamba Demethylation System in Rhizorhabdus dicambivorans Ndbn-20

Shigang Yao, Le Chen, Zhou Yang, Li Yao, Jianchun Zhu, Jiguo Qiu, Guoxiang Wang, Jian He

J Bacteriol. 2019 Sep 1; 201(17): e00096-19. Prepublished online 2019 Jun 17. Published online 2019 Aug 8. doi: 10.1128/JB.00096-19

PMCID:: PMC6689297

Abstract Article PDF–1.9M

Select item 661569412.

A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

Sakunrat Ubonprasert, Juthamas Jaroensuk, Wichai Pornthanakasem, Nuntaporn Kamonsutthipaijit, Peerapong Wongpituk, Pitchayathida Mee-udorn, Thanyada Rungrotmongkol, Onuma Ketchart, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen, Somchart Maenpuen

J Biol Chem. 2019 Jul 5; 294(27): 10490–10502. Published online 2019 May 22. doi: 10.1074/jbc.RA119.007454

PMCID:: PMC6615694

Abstract Article PDF–2.3M

Select item 661492013.

Responsive self-assembly of tectoRNAs with loop–receptor interactions from the tetrahydrofolate (THF) riboswitch

Charles Mitchell, Julio A Polanco, Laura DeWald, Dustin Kress, Luc Jaeger, Wade W Grabow

Nucleic Acids Res. 2019 Jul 9; 47(12): 6439–6451. Published online 2019 May 2. doi: 10.1093/nar/gkz304

PMCID:: PMC6614920

Abstract Article PDF–3.7M

Select item 656831314.

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Yuxiang Zheng, Ting-Yu Lin, Gina Lee, Marcia N. Paddock, Jessica Momb, Zhe Cheng, Qian Li, Dennis L. Fei, Benjamin D. Stein, Shivan Ramsamooj, Guoan Zhang, John Blenis, Lewis C. Cantley

Cell. Author manuscript; available in PMC 2019 Nov 29.

Published in final edited form as: Cell. 2018 Nov 29; 175(6): 1546–1560.e17. doi: 10.1016/j.cell.2018.09.041

PMCID:: PMC6568313

Abstract Article PDF–2.5M

Select item 656781515.

Metabolic Intermediates in Tumorigenesis and Progression

Yuchen He, Menghui Gao, Haosheng Tang, Yiqu Cao, Shuang Liu, Yongguang Tao

Int J Biol Sci. 2019; 15(6): 1187–1199. Published online 2019 May 7. doi: 10.7150/ijbs.33496

PMCID:: PMC6567815

Abstract Article PDF–1.3M

Select item 641629716.

The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism

Karla Misselbeck, Luca Marchetti, Corrado Priami, Patrick J. Stover, Martha S. Field

Sci Rep. 2019; 9: 4322. Published online 2019 Mar 13. doi: 10.1038/s41598-019-40230-4

PMCID:: PMC6416297

Abstract Article PDF–1.5M

Select item 626818317.

Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate

Shouxin Zhou, Chao Tian, Chao Li, Ying Guo, Xiaowei Wang, Junyi Liu, Zhili Zhang

Molecules. 2012 May; 17(5): 5604–5614. Published online 2012 May 10. doi: 10.3390/molecules17055604

PMCID:: PMC6268183

Abstract Article PDF–307K

Select item 624233718.

A Single Mutation Traps a Half-sites Reactive Enzyme in Mid-stream, Explaining Asymmetry in Hydride Transfer^†

Janet S. Finer-Moore, Tom T. Lee, Robert M. Stroud

Biochemistry. Author manuscript; available in PMC 2018 Nov 19.

Published in final edited form as: Biochemistry. 2018 May 15; 57(19): 2786–2795. Published online 2018 May 2. doi: 10.1021/acs.biochem.8b00176

PMCID:: PMC6242337

Abstract Article PDF–2.4M

Select item 622220119.

Coenzyme F₄₂₀-Dependent Glucose-6-Phosphate Dehydrogenase-Coupled Polyglutamylation of Coenzyme F₄₂₀ in Mycobacteria

Endang Purwantini, Usha Loganathan, Biswarup Mukhopadhyay

J Bacteriol. 2018 Dec 1; 200(23): e00375-18. Prepublished online 2018 Sep 24. Published online 2018 Nov 6. doi: 10.1128/JB.00375-18

PMCID:: PMC6222201

Abstract Article PDF–1.3M

Select item 621948620.

Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells

Clara B. García-Calderón, José Antonio Bejarano-García, Isabel Tinoco-Gago, María José Castro, Paula Moreno-Gordillo, José I. Piruat, Teresa Caballero-Velázquez, José A. Pérez-Simón, Iván V. Rosado

Cell Death Differ. 2018 Nov; 25(11): 1967–1979. Published online 2018 Mar 6. doi: 10.1038/s41418-018-0089-4