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Select item 108992111.

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice

Calvin Simerly, Emily Robertson, Caleb Harrison, Sydney Ward, Charlize George, Jasmine Deleon, Carrie Hartnett, Gerald Schatten

Sci Rep. 2024; 14: 4808. Published online 2024 Feb 27. doi: 10.1038/s41598-024-55376-z

PMCID:: PMC10899211

Abstract Article PDF–8.5M

Select item 108556272.

1,6-Hexanediol Is Inducing Homologous Recombination by Releasing BLM from Assemblysomes in Drosophila melanogaster

Bence György Gombás, Zoltán Villányi

Int J Mol Sci. 2024 Feb; 25(3): 1611. Published online 2024 Jan 28. doi: 10.3390/ijms25031611

PMCID:: PMC10855627

Abstract Article PDF–2.1M

Select item 104643383.

Investigating phase separation properties of chromatin-associated proteins using gradient elution of 1,6-hexanediol

Peiyu Zhu, Chao Hou, Manlin Liu, Taoyu Chen, Tingting Li, Likun Wang

BMC Genomics. 2023; 24: 493. Published online 2023 Aug 28. doi: 10.1186/s12864-023-09600-1

PMCID:: PMC10464338

Abstract Article PDF–5.4M

Select item 104115644.

Impact of 1,6-hexanediol on Schizosaccharomyces pombe genome stability

Chance E Jones, Susan L Forsburg

G3 (Bethesda) 2023 Aug; 13(8): jkad123. Published online 2023 Jun 7. doi: 10.1093/g3journal/jkad123

PMCID:: PMC10411564

Abstract Article PDF–790K

Select item 103665325.

Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops

Iain Williamson, Shelagh Boyle, Graeme R Grimes, Elias T Friman, Wendy A Bickmore

Life Sci Alliance. 2023 Oct; 6(10): e202302101. Published online 2023 Jul 24. doi: 10.26508/lsa.202302101

Correction in:: Life Sci Alliance. 2024 Jan; 7(1): e202302436.

PMCID:: PMC10366532

Abstract Article PDF–3.9M

Select item 100809756.

1,6-Hexanediol regulates angiogenesis via suppression of cyclin A1-mediated endothelial function

Yongying Jiang, Gongyun Lei, Ting Lin, Nan Zhou, Jintao Wu, Zhou Wang, Yihui Fan, Hongzhuan Sheng, Renfang Mao

BMC Biol. 2023; 21: 75. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01580-8

PMCID:: PMC10080975

Abstract Article PDF–3.8M

Select item 96173317.

A facile process for adipic acid production in high yield by oxidation of 1,6-hexanediol using the resting cells of Gluconobacter oxydans

Sang-Hyun Pyo, Mahmoud Sayed, Oliver Englund Örn, Jorge Amorrortu Gallo, Nídia Fernandez Ros, Rajni Hatti-Kaul

Microb Cell Fact. 2022; 21: 223. Published online 2022 Oct 28. doi: 10.1186/s12934-022-01947-6

PMCID:: PMC9617331

Abstract Article PDF–1.2M

Select item 94860378.

Phase-separation antagonists potently inhibit transcription and broadly increase nucleosome density

Rajyalakshmi Meduri, Linda S. Rubio, Suman Mohajan, David S. Gross

J Biol Chem. 2022 Oct; 298(10): 102365. Published online 2022 Aug 11. doi: 10.1016/j.jbc.2022.102365

PMCID:: PMC9486037

Abstract Article PDF–1.5M

Select item 86752919.

How do protein domains of low sequence complexity work?

Masato Kato, Xiaoming Zhou, Steven L. McKnight

RNA. 2022 Jan; 28(1): 3–15. doi: 10.1261/rna.078990.121

PMCID:: PMC8675291

Abstract Article PDF–1.1M

Select item 856164310.

Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses

Florian Geiger, Julia Acker, Guido Papa, Xinyu Wang, William E Arter, Kadi L Saar, Nadia A Erkamp, Runzhang Qi, Jack PK Bravo, Sebastian Strauss, Georg Krainer, Oscar R Burrone, Ralf Jungmann, Tuomas PJ Knowles, Hanna Engelke, Alexander Borodavka

EMBO J. 2021 Nov 2; 40(21): e107711. Published online 2021 Sep 15. doi: 10.15252/embj.2021107711

PMCID:: PMC8561643

Abstract Article PDF–5.6M

Select item 850196911.

Suppression of liquid–liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells

Sergey V Ulianov, Artem K Velichko, Mikhail D Magnitov, Artem V Luzhin, Arkadiy K Golov, Natalia Ovsyannikova, Igor I Kireev, Alexey S Gavrikov, Alexander S Mishin, Azat K Garaev, Alexander V Tyakht, Alexey A Gavrilov, Omar L Kantidze, Sergey V Razin

Nucleic Acids Res. 2021 Oct 11; 49(18): 10524–10541. Published online 2021 Apr 9. doi: 10.1093/nar/gkab249

PMCID:: PMC8501969

Abstract Article PDF–7.8M

Select item 842499212.

Multivalent electrostatic pi–cation interaction between synaptophysin and synapsin is responsible for the coacervation

Goeun Kim, Sang-Eun Lee, Seonyoung Jeong, Jeongkun Lee, Daehun Park, Sunghoe Chang

Mol Brain. 2021; 14: 137. Published online 2021 Sep 8. doi: 10.1186/s13041-021-00846-y

PMCID:: PMC8424992

Abstract Article PDF–2.0M

Select item 836980013.

Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization

Xinyi Liu, Shaoshuai Jiang, Lin Ma, Jiale Qu, Longying Zhao, Xing Zhu, Junjun Ding

Genome Biol. 2021; 22: 230. Published online 2021 Aug 17. doi: 10.1186/s13059-021-02455-3

PMCID:: PMC8369800

Abstract Article PDF–5.3M

Select item 836965114.

Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index

Minglei Shi, Kaiqiang You, Taoyu Chen, Chao Hou, Zhengyu Liang, Mingwei Liu, Jifeng Wang, Taotao Wei, Jun Qin, Yang Chen, Michael Q. Zhang, Tingting Li

Genome Biol. 2021; 22: 229. Published online 2021 Aug 17. doi: 10.1186/s13059-021-02456-2

PMCID:: PMC8369651

Abstract Article PDF–3.6M

Select item 825259415.

RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells

Takashi Imada, Takeshi Shimi, Ai Kaiho, Yasushi Saeki, Hiroshi Kimura

Genes Cells. 2021 May; 26(5): 298–312. Published online 2021 Mar 19. doi: 10.1111/gtc.12840

PMCID:: PMC8252594

Abstract Article PDF–1.8M

Select item 806886416.

The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus

Can Balaban, Martin Sztacho, Michaela Blažíková, Pavel Hozák

Cells. 2021 Apr; 10(4): 848. Published online 2021 Apr 8. doi: 10.3390/cells10040848

PMCID:: PMC8068864

Abstract Article PDF–6.3M

Select item 794859517.

1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities

Robert Düster, Ines H. Kaltheuner, Maximilian Schmitz, Matthias Geyer

J Biol Chem. 2021 Jan-Jun; 296: 100260. Published online 2021 Jan 8. doi: 10.1016/j.jbc.2021.100260

PMCID:: PMC7948595

Abstract Article PDF–1.4M

Select item 789866218.

1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells

Yuji Itoh, Shiori Iida, Sachiko Tamura, Ryosuke Nagashima, Kentaro Shiraki, Tatsuhiko Goto, Kayo Hibino, Satoru Ide, Kazuhiro Maeshima

Life Sci Alliance. 2021 Apr; 4(4): e202001005. Published online 2021 Feb 3. doi: 10.26508/lsa.202001005

PMCID:: PMC7898662

Abstract Article PDF–2.3M

Select item 780137919.

BET inhibition disrupts transcription but retains enhancer-promoter contact

Nicholas T. Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Tapia, Peng Hua, Christoffer Lagerholm, Panagis Filippakopoulos, James O. J. Davies, Thomas A. Milne

Nat Commun. 2021; 12: 223. Published online 2021 Jan 11. doi: 10.1038/s41467-020-20400-z