PMC Articles for PubChem BioAssay (Select 1345548) - PMC

Select item 53984151.

Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

Lohith Bachegowda, Kerry Morrone, Shannon L. Winski, Ioannis Mantzaris, Matthias Bartenstein, Nandini Ramachandra, Orsi Giricz, Vineeth Sukrithan, George Nwankwo, Samira Shahnaz, Tushar Bhagat, Sanchari Bhattacharyya, Amer Assal, Aditi Shastri, Shanisha Gordon-Mitchell, Andrea Pellagatti, Jacqueline Boultwood, Carolina Schinke, Yiting Yu, Chandan Guha, James Rizzi, Jennifer Garrus, Suzy Brown, Lance Wollenberg, Grant Hogeland, Dale Wright, Mark Munson, Mareli Rodriguez, Stefan Gross, David Chantry, Yiyu Zou, Leonidas Platanias, Laurence E. Burgess, Kith Pradhan, Ulrich Steidl, Amit Verma

Cancer Res. Author manuscript; available in PMC 2017 Aug 15.

Published in final edited form as: Cancer Res. 2016 Aug 15; 76(16): 4841–4849. Published online 2016 Jun 10. doi: 10.1158/0008-5472.CAN-15-3062

PMCID:: PMC5398415

Abstract Article PDF–2.1M

Select item 48261922.

Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma

Parag P. Patwardhan, Kathryn S. Ivy, Elgilda Musi, Elisa de Stanchina, Gary K. Schwartz

Oncotarget. 2016 Jan 26; 7(4): 4093–4109. Published online 2015 Dec 10. doi: 10.18632/oncotarget.6547

PMCID:: PMC4826192

Abstract Article PDF–6.5M

Select item 46224583.

Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy

Qiaoling Sun, Jinghong Zhou, Zheng Zhang, Mingchuan Guo, Junqing Liang, Feng Zhou, Jingwen Long, Wei Zhang, Fang Yin, Huaqing Cai, Haibin Yang, Weihan Zhang, Yi Gu, Liang Ni, Yang Sai, Yumin Cui, Meifang Zhang, Minhua Hong, Junen Sun, Zheng Yang, Weiguo Qing, Weiguo Su, Yongxin Ren

Cancer Biol Ther. 2014 Dec; 15(12): 1635–1645. Published online 2014 Oct 29. doi: 10.4161/15384047.2014.964087

PMCID:: PMC4622458

Abstract Article PDF–1012K

Select item 38234254.

AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and anti-tumour activity via targeting VEGFR, FGFR and PDGFR

Yuanfeng Zhou, Yi Chen, Linjiang Tong, Hua Xie, Weiwei Wen, Jie Zhang, Yong Xi, Yanyan Shen, Meiyu Geng, Yuanyuan Wang, Hualiang Jiang, Cheng Luo, Liping Lin, Jian Ding

J Cell Mol Med. 2012 Oct; 16(10): 2321–2330. Published online 2012 Sep 26. doi: 10.1111/j.1582-4934.2012.01541.x

PMCID:: PMC3823425

Abstract Article PDF–451K

Select item 36155545.

A High-Content Biosensor Based Screen Identifies Cell Permeable Activators and Inhibitors of EGFR Function: Implications in Drug Discovery

Christophe Antczak, Jeni P. Mahida, Bhavneet Bhinder, Paul A. Calder, Hakim Djaballah

J Biomol Screen. Author manuscript; available in PMC 2013 Apr 3.

Published in final edited form as: J Biomol Screen. 2012 Aug; 17(7): 885–899. Published online 2012 May 9. doi: 10.1177/1087057112446174

PMCID:: PMC3615554

Abstract Article PDF–3.3M

Select item 29575606.

The rational design of a novel potent analogue of the 5’-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity

Fouzia Machrouhi, Nouara Ouhamou, Keith Laderoute, Joy Calaoagan, Marina Bukhtiyarova, Paula J. Ehrlich, Anthony E. Klon

Bioorg Med Chem Lett. Author manuscript; available in PMC 2011 Nov 15.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Nov 15; 20(22): 6394–6399. Published online 2010 Sep 19. doi: 10.1016/j.bmcl.2010.09.088

PMCID:: PMC2957560

Abstract Article PDF–1.7M

Select item 21544647.

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Oleg Fedorov, Brian Marsden, Vanda Pogacic, Peter Rellos, Susanne Müller, Alex N. Bullock, Juerg Schwaller, Michael Sundström, Stefan Knapp

Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51): 20523–20528. Published online 2007 Dec 11. doi: 10.1073/pnas.0708800104

PMCID:: PMC2154464

Abstract Article PDF–1.3M

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