PMC Links for OMIM (Select 600244) - PMC

Select item 59313751.

PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity

Sydney R. Gordon, Roy L. Maute, Ben W. Dulken, Gregor Hutter, Benson M. George, Melissa N. McCracken, Rohit Gupta, Jonathan M. Tsai, Rahul Sinha, Daniel Corey, Aaron M. Ring, Andrew J. Connolly, Irving L. Weissman

Nature. Author manuscript; available in PMC 2018 May 2.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 495–499. Published online 2017 May 17. doi: 10.1038/nature22396

PMCID:: PMC5931375

Abstract Article PDF–1.7M

Select item 58212142.

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

Tim Wartewig, Zsuzsanna Kurgyis, Selina Keppler, Konstanze Pechloff, Erik Hameister, Rupert Öllinger, Roman Maresch, Thorsten Buch, Katja Steiger, Christof Winter, Roland Rad, Jürgen Ruland

Nature. Author manuscript; available in PMC 2018 May 15.

Published in final edited form as: Nature. 2017 Dec 7; 552(7683): 121–125. Published online 2017 Nov 15. doi: 10.1038/nature24649

PMCID:: PMC5821214

Abstract Article PDF–4.8M

Select item 55761423.

Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le, Jennifer N. Durham, Kellie N. Smith, Hao Wang, Bjarne R. Bartlett, Laveet K. Aulakh, Steve Lu, Holly Kemberling, Cara Wilt, Brandon S. Luber, Fay Wong, Nilofer S. Azad, Agnieszka A. Rucki, Dan Laheru, Ross Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Tim F. Greten, Austin G. Duffy, Kristen K. Ciombor, Aleksandra D. Eyring, Bao H. Lam, Andrew Joe, S. Peter Kang, Matthias Holdhoff, Ludmila Danilova, Leslie Cope, Christian Meyer, Shibin Zhou, Richard M. Goldberg, Deborah K. Armstrong, Katherine M. Bever, Amanda N. Fader, Janis Taube, Franck Housseau, David Spetzler, Nianqing Xiao, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, James R. Eshleman, Bert Vogelstein, Robert A. Anders, Luis A. Diaz, Jr.

Science. Author manuscript; available in PMC 2017 Aug 30.

Published in final edited form as: Science. 2017 Jul 28; 357(6349): 409–413. Published online 2017 Jun 8. doi: 10.1126/science.aan6733

PMCID:: PMC5576142

Abstract Article PDF–671K

Select item 54975894.

The epigenetic landscape of T cell exhaustion

Debattama R. Sen, James Kaminski, R. Anthony Barnitz, Makoto Kurachi, Ulrike Gerdemann, Kathleen B. Yates, Hsiao-Wei Tsao, Jernej Godec, Martin W. LaFleur, Flavian D. Brown, Pierre Tonnerre, Raymond T. Chung, Damien C. Tully, Todd M. Allen, Nicole Frahm, Georg M. Lauer, E. John Wherry, Nir Yosef, W. Nicholas Haining

Science. Author manuscript; available in PMC 2017 Dec 2.

Published in final edited form as: Science. 2016 Dec 2; 354(6316): 1165–1169. Published online 2016 Oct 27. doi: 10.1126/science.aae0491

PMCID:: PMC5497589

Abstract Article PDF–942K

Select item 54847955.

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi, Sasikanth Manne, Jernej Godec, Omar Khan, Adam M. Drake, Zeyu Chen, Debattama R. Sen, Makoto Kurachi, R. Anthony Barnitz, Caroline Bartman, Bertram Bengsch, Alexander C. Huang, Jason M. Schenkel, Golnaz Vahedi, W. Nicholas Haining, Shelley L. Berger, E. John Wherry

Science. Author manuscript; available in PMC 2017 Jun 27.

Published in final edited form as: Science. 2016 Dec 2; 354(6316): 1160–1165. Published online 2016 Oct 27. doi: 10.1126/science.aaf2807

PMCID:: PMC5484795

Abstract Article PDF–1.9M

Select item 54083206.

Loss of PTEN associated with resistance to anti-PD-1 checkpoint blockade therapy in metastatic uterine leiomyosarcoma

Suzanne George, Diana Miao, George D. Demetri, Dennis Adeegbe, Scott J. Rodig, Sachet Shukla, Mikel Lipschitz, Ali Amin-Mansour, Chandrajit P. Raut, Scott L. Carter, Peter Hammerman, Gordon J. Freeman, Catherine J. Wu, Patrick A. Ott, Kwok-Kin Wong, Eliezer M. Van Allen

Immunity. Author manuscript; available in PMC 2018 Feb 21.

Published in final edited form as: Immunity. 2017 Feb 21; 46(2): 197–204. doi: 10.1016/j.immuni.2017.02.001

PMCID:: PMC5408320

Abstract Article PDF–933K

Select item 42291347.

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4⁺ T cell activation during HIV infection

Elias A Said, Franck P Dupuy, Lydie Trautmann, Yuwei Zhang, Yu Shi, Mohamed El-Far, Brenna J Hill, Alessandra Noto, Petronela Ancuta, Yoav Peretz, Simone G Fonseca, Julien Van Grevenynghe, Mohamed R Boulassel, Julie Bruneau, Naglaa H Shoukry, Jean-Pierre Routy, Daniel C Douek, Elias K Haddad, Rafick-Pierre Sekaly

Nat Med. Author manuscript; available in PMC 2014 Nov 12.

Published in final edited form as: Nat Med. 2010 Apr; 16(4): 452–459. Published online 2010 Mar 7. doi: 10.1038/nm.2106

PMCID:: PMC4229134

Abstract Article PDF–610K

Select item 37190688.

Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia

Wen Yang, Yan Song, Yun-Long Lu, Jun-Zhong Sun, Hong-Wei Wang

Immunology. 2013 Aug; 139(4): 513–522. Published online 2013 Jul 2. doi: 10.1111/imm.12101

PMCID:: PMC3719068

Abstract Article PDF–383K

Select item 33265779.

Integrative genomic analysis of HIV-specific CD8⁺ T cells reveals that PD-1 inhibits T cell function by upregulating BATF

Michael Quigley, Florencia Pereyra, Björn Nilsson, Filippos Porichis, Catia Fonseca, Quentin Eichbaum, Boris Julg, Jonathan L. Jesneck, Kathleen Brosnahan, Sabrina Imam, Kate Russell, Ildiko Toth, Alicja Piechocka-Trocha, Douglas Dolfi, Jill Angelosanto, Alison Crawford, Haina Shin, Douglas S. Kwon, Jennifer Zupkosky, Loise Francisco, Gordon J. Freeman, E. John Wherry, Daniel E. Kaufmann, Bruce D. Walker, Benjamin Ebert, W. Nicholas Haining

Nat Med. Author manuscript; available in PMC 2012 Apr 16.

Published in final edited form as: Nat Med. 2010 Oct; 16(10): 1147–1151. Published online 2010 Oct 3. doi: 10.1038/nm.2232

PMCID:: PMC3326577

Article PDF–1.1M

Select item 226819210.

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

Eszter Lázár-Molnár, Attila Gácser, Gordon J. Freeman, Steven C. Almo, Stanley G. Nathenson, Joshua D. Nosanchuk

Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7): 2658–2663. Published online 2008 Feb 11. doi: 10.1073/pnas.0711918105

PMCID:: PMC2268192

Abstract Article PDF–988K

Select item 221295611.

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b^−/−Pdcd1^−/− mice

Taku Okazaki, Yumi Otaka, Jian Wang, Hiroshi Hiai, Toshiyuki Takai, Jeffrey V. Ravetch, Tasuku Honjo

J Exp Med. 2005 Dec 19; 202(12): 1643–1648. doi: 10.1084/jem.20051984

PMCID:: PMC2212956

Abstract Article PDF–1.2M

Select item 219331112.

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai, Karen Bourque, Tatyana Chernova, Hiroyuki Nishimura, Lori J. Fitz, Nelly Malenkovich, Taku Okazaki, Michael C. Byrne, Heidi F. Horton, Lynette Fouser, Laura Carter, Vincent Ling, Michael R. Bowman, Beatriz M. Carreno, Mary Collins, Clive R. Wood, Tasuku Honjo

J Exp Med. 2000 Oct 2; 192(7): 1027–1034. doi: 10.1084/jem.192.7.1027

PMCID:: PMC2193311

Abstract Article PDF–365K

Select item 55689813.

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

Y Ishida, Y Agata, K Shibahara, T Honjo

EMBO J. 1992 Nov; 11(11): 3887–3895. doi: 10.1002/j.1460-2075.1992.tb05481.x

PMCID:: PMC556898

Summary Page Browse PDF–1.8M

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