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Select item 69856561.

SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection

Wei Ouyang, Chao Liu, Ying Pan, Yu Han, Liping Yang, Jingyan Xia, Feng Xu

Cell Prolif. 2020 Jan; 53(1): e12721. Published online 2019 Nov 29. doi: 10.1111/cpr.12721

PMCID:: PMC6985656

Article PDF–1.1M

Select item 68000252.

Excitatory neuron–specific SHP2-ERK signaling network regulates synaptic plasticity and memory

Hyun-Hee Ryu, TaeHyun Kim, Jung-Woong Kim, Minkyung Kang, Pojeong Park, Yong Gyu Kim, Hyopil Kim, Jiyeon Ha, Ja Eun Choi, Jisu Lee, Chae-Seok Lim, Chul-Hong Kim, Sang Jeong Kim, Alcino J. Silva, Bong-Kiun Kaang, Yong-Seok Lee

Sci Signal. Author manuscript; available in PMC 2019 Oct 18.

Published in final edited form as: Sci Signal. 2019 Mar 5; 12(571): eaau5755. Published online 2019 Mar 5. doi: 10.1126/scisignal.aau5755

PMCID:: PMC6800025

Article PDF–2.2M

Select item 67698793.

The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity

Yvonn Heun, Katharina Grundler Groterhorst, Kristin Pogoda, Bjoern F Kraemer, Alexander Pfeifer, Ulrich Pohl, Hanna Mannell

Int J Mol Sci. 2019 Sep; 20(18): 4404. Published online 2019 Sep 7. doi: 10.3390/ijms20184404

PMCID:: PMC6769879

Article PDF–2.1M

Select item 64437814.

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Eunhee Choi, Sotaro Kikuchi, Haishan Gao, Karolina Brodzik, Ibrahim Nassour, Adam Yopp, Amit G. Singal, Hao Zhu, Hongtao Yu

Nat Commun. 2019; 10: 1473. Published online 2019 Apr 1. doi: 10.1038/s41467-019-09318-3

PMCID:: PMC6443781

Article PDF–5.9M

Select item 64410795.

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Charlène Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda

Nat Commun. 2019; 10: 1444. Published online 2019 Mar 29. doi: 10.1038/s41467-019-09431-3

PMCID:: PMC6441079

Article PDF–1.6M

Select item 68598346.

Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation

Wenqian Li, Yinjiao Li, Kewei Qin, Boxiang Du, Tianliang Li, Hongbin Yuan, Chaofeng Han, Yan Luo

Front Immunol. 2019; 10: 2575. Published online 2019 Nov 7. doi: 10.3389/fimmu.2019.02575

PMCID:: PMC6859834

Article PDF–2.1M

Select item 66371527.

Gas6 is a reciprocal regulator of mitophagy during mammalian oocyte maturation

Kyeoung-Hwa Kim, Eun-Young Kim, Jung-Jae Ko, Kyung-Ah Lee

Sci Rep. 2019; 9: 10343. Published online 2019 Jul 17. doi: 10.1038/s41598-019-46459-3

PMCID:: PMC6637152

Article PDF–4.0M

Select item 65239868.

Regulation of Microtubule Nucleation in Mouse Bone Marrow-Derived Mast Cells by Protein Tyrosine Phosphatase SHP-1

Anastasiya Klebanovych, Vladimíra Sládková, Tetyana Sulimenko, Věra Vosecká, Zuzana Rubíková, Martin Čapek, Eduarda Dráberová, Pavel Dráber, Vadym Sulimenko

Cells. 2019 Apr; 8(4): 345. Published online 2019 Apr 11. doi: 10.3390/cells8040345

PMCID:: PMC6523986

Article PDF–3.1M

Select item 62305929.

ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases

Doaa Glal, Janaki N. Sudhakar, Hsueh-Han Lu, Ming-Che Liu, Hung-Yu Chiang, Yen-Chun Liu, Ching-Feng Cheng, Jr-Wen Shui

Front Immunol. 2018; 9: 2522. Published online 2018 Nov 5. doi: 10.3389/fimmu.2018.02522

PMCID:: PMC6230592

Article PDF–9.6M

Select item 593201210.

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

Axel Hyrenius-Wittsten, Mattias Pilheden, Helena Sturesson, Jenny Hansson, Michael P. Walsh, Guangchun Song, Julhash U. Kazi, Jian Liu, Ramprasad Ramakrishan, Cristian Garcia-Ruiz, Stephanie Nance, Pankaj Gupta, Jinghui Zhang, Lars Rönnstrand, Anne Hultquist, James R. Downing, Karin Lindkvist-Petersson, Kajsa Paulsson, Marcus Järås, Tanja A. Gruber, Jing Ma, Anna K. Hagström-Andersson

Nat Commun. 2018; 9: 1770. Published online 2018 May 2. doi: 10.1038/s41467-018-04180-1

PMCID:: PMC5932012

Article PDF–2.0M

Select item 508147111.

Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation

Gyun Jee Song, Jaehong Kim, Jong-Heon Kim, Seungeun Song, Hana Park, Zhong-Yin Zhang, Kyoungho Suk

Exp Neurobiol. 2016 Oct; 25(5): 252–261. Published online 2016 Oct 20. doi: 10.5607/en.2016.25.5.252

PMCID:: PMC5081471

Article PDF–924K

Select item 506155512.

RGC-32 is a novel regulator of the T-lymphocyte cell cycle

Cosmin A. Tegla, Cornelia D. Cudrici, Vinh Nguyen, Jacob Danoff, Adam M. Kruszewski, Dallas Boodhoo, Armugam P. Mekala, Sonia I. Vlaicu, Ching Chen, Violeta Rus, Tudor C. Badea, Horea Rus

Exp Mol Pathol. Author manuscript; available in PMC 2016 Oct 12.

Published in final edited form as: Exp Mol Pathol. 2015 Jun; 98(3): 328–337. Published online 2015 Mar 11. doi: 10.1016/j.yexmp.2015.03.011

PMCID:: PMC5061555

Article PDF–1011K

Select item 428164413.

The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration

Michelle A. Edwards, Kathryn Crombie, Christine Schramm, Maike Krenz

J Appl Physiol (1985) 2015 Jan 1; 118(1): 124–131. Published online 2014 Oct 30. doi: 10.1152/japplphysiol.00008.2014

PMCID:: PMC4281644

Article

Select item 379477314.

Pattern-Recognition Receptor Signaling Regulator mRNA Expression in Humans and Mice, and in Transient Inflammation or Progressive Fibrosis

Roman Günthner, Vankayala Ramaiah Santhosh Kumar, Georg Lorenz, Hans-Joachim Anders, Maciej Lech

Int J Mol Sci. 2013 Sep; 14(9): 18124–18147. Published online 2013 Sep 4. doi: 10.3390/ijms140918124

PMCID:: PMC3794773

Article PDF–5.9M

Select item 368997515.

New Approaches to Prevent LEOPARD Syndrome-associated Cardiac Hypertrophy by Specifically Targeting Shp2-dependent Signaling

Christine Schramm, Michelle A. Edwards, Maike Krenz

J Biol Chem. 2013 Jun 21; 288(25): 18335–18344. Published online 2013 May 14. doi: 10.1074/jbc.M113.483800

PMCID:: PMC3689975

Article PDF–2.3M

Select item 365045116.

Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice

Li-ya Wang, Ning Wang, Fang Le, Lei Li, Le-jun Li, Xiao-zhen Liu, Ying-ming Zheng, Hang-ying Lou, Xiang-rong Xu, Xiao-ming Zhu, Yi-min Zhu, He-feng Huang, Fan Jin

J Zhejiang Univ Sci B. 2013 May; 14(5): 372–381. doi: 10.1631/jzus.B1200321