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Select item 69424211.

Ubiquitin carboxyl‐terminal hydrolase L1 promotes hypoxia‐inducible factor 1‐dependent tumor cell malignancy in spheroid models

Xuebing Li, Akira Hattori, Senye Takahashi, Yoko Goto, Hiroshi Harada, Hideaki Kakeya

Cancer Sci. 2020 Jan; 111(1): 239–252. Published online 2019 Dec 10. doi: 10.1111/cas.14236

PMCID:: PMC6942421

Article PDF–2.6M

Select item 3604822.

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

G L Semenza, G L Wang

Mol Cell Biol. 1992 Dec; 12(12): 5447–5454. doi: 10.1128/mcb.12.12.5447

PMCID:: PMC360482

Article PDF–1.8M

Select item 464953.

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

G L Wang, G L Semenza

Proc Natl Acad Sci U S A. 1993 May 1; 90(9): 4304–4308. doi: 10.1073/pnas.90.9.4304

PMCID:: PMC46495

Article PDF–1.5M

Select item 417254.

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, B H Jiang, E A Rue, G L Semenza

Proc Natl Acad Sci U S A. 1995 Jun 6; 92(12): 5510–5514. doi: 10.1073/pnas.92.12.5510

PMCID:: PMC41725

Article PDF–1.4M

Select item 69099545.

HPV 16 E6/E7 up-regulate the expression of both HIF-1α and GLUT1 by inhibition of RRAD and activation of NF-κB in lung cancer cells

Na-Jin Gu, Ming-Zhe Wu, Ling He, Xu-Bo Wang, Shiyu Wang, Xue-Shan Qiu, En-Hua Wang, Guang-Ping Wu

J Cancer. 2019; 10(27): 6903–6909. Published online 2019 Nov 17. doi: 10.7150/jca.37070

PMCID:: PMC6909954

Article PDF–1.0M

Select item 68839766.

Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells

Qian Xu, Zhihua Liu, Ling Guo, Rui Liu, Rulei Li, Xiang Chu, Jiajia Yang, Jia Luo, Faming Chen, Manjing Deng

Mol Cells. 2019 Nov; 42(11): 763–772. Published online 2019 Oct 29. doi: 10.14348/molcells.2019.0023

PMCID:: PMC6883976

Article PDF–5.2M

Select item 68213157.

HIF-transcribed p53 chaperones HIF-1α

Esha Madan, Taylor M Parker, Christopher J Pelham, Antonio M Palma, Maria L Peixoto, Masaki Nagane, Aliya Chandaria, Ana R Tomás, Rita Canas-Marques, Vanessa Henriques, Antonio Galzerano, Joaquim Cabral-Teixeira, Karuppaiyah Selvendiran, Periannan Kuppusamy, Carlos Carvalho, Antonio Beltran, Eduardo Moreno, Uttam K Pati, Rajan Gogna

Nucleic Acids Res. 2019 Nov 4; 47(19): 10212–10234. Published online 2019 Sep 20. doi: 10.1093/nar/gkz766

PMCID:: PMC6821315

Article PDF–7.9M

Select item 67541478.

Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues

Neire Niara Ferreira de Araujo, Hui Tzu Lin-Wang, Juliana de Freitas Germano, Pedro Silvio Farsky, Andre Feldman, Fabio Henrique Rossi, Nilo Mitsuru Izukawa, Maria de Lourdes Higuchi, Felicio Savioli Neto, Mario Hiroyuki Hirata, Marcelo Chiara Bertolami

PLoS One. 2019; 14(9): e0222782. Published online 2019 Sep 20. doi: 10.1371/journal.pone.0222782

PMCID:: PMC6754147

Article PDF–1.0M

Select item 67098819.

Modeling Retinitis Pigmentosa: Retinal Organoids Generated From the iPSCs of a Patient With the USH2A Mutation Show Early Developmental Abnormalities

Yonglong Guo, Peiyuan Wang, Jacey Hongjie Ma, Zekai Cui, Quan Yu, Shiwei Liu, Yunxia Xue, Deliang Zhu, Jixing Cao, Zhijie Li, Shibo Tang, Jiansu Chen

Front Cell Neurosci. 2019; 13: 361. Published online 2019 Aug 7. doi: 10.3389/fncel.2019.00361

PMCID:: PMC6709881

Article PDF–8.0M

Select item 669427210.

Differential expression of genes associated with hypoxia pathway on bone marrow stem cells in osteoporosis patients with different bone mass index

Qi Zhu, Chang Shan, Ling Li, Lige Song, Keqin Zhang, Yun Zhou

Ann Transl Med. 2019 Jul; 7(14): 309. doi: 10.21037/atm.2019.06.27

PMCID:: PMC6694272

Article PDF–3.5M

Select item 654992711.

Repressive role of stabilized hypoxia inducible factor 1α expression on transforming growth factor β‐induced extracellular matrix production in lung cancer cells

Akira Ando, Naozumi Hashimoto, Koji Sakamoto, Norihito Omote, Shinichi Miyazaki, Yoshio Nakahara, Kazuyoshi Imaizumi, Tsutomu Kawabe, Yoshinori Hasegawa

Cancer Sci. 2019 Jun; 110(6): 1959–1973. Published online 2019 May 13. doi: 10.1111/cas.14027

PMCID:: PMC6549927

Article PDF–3.2M

Select item 653958712.

Fucoidan inhibits epithelial-to-mesenchymal transition via regulation of the HIF-1α pathway in mammary cancer cells under hypoxia

Weiwei Li, Dingshan Xue, Meilan Xue, Jinglan Zhao, Hui Liang, Ying Liu, Ting Sun

Oncol Lett. 2019 Jul; 18(1): 330–338. Published online 2019 Apr 25. doi: 10.3892/ol.2019.10283

PMCID:: PMC6539587

Article PDF–1.7M

Select item 648701913.

MiR-200c downregulates HIF-1α and inhibits migration of lung cancer cells

Yuree Byun, Young-Chul Choi, Yunhui Jeong, Gangtae Lee, Sena Yoon, Yongsu Jeong, Jaeseung Yoon, Kwanghee Baek

Cell Mol Biol Lett. 2019; 24: 28. Published online 2019 Apr 27. doi: 10.1186/s11658-019-0152-2

PMCID:: PMC6487019

Article PDF–1.3M

Select item 642685314.

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

Lisha Xiang, Jun Mou, Bin Shao, Yuquan Wei, Houjie Liang, Naoharu Takano, Gregg L. Semenza, Ganfeng Xie

Cell Death Dis. 2019 Feb; 10(2): 40. Published online 2019 Jan 17. doi: 10.1038/s41419-018-1291-5

PMCID:: PMC6426853

Article PDF–2.5M

Select item 640654415.

Translating the Hypoxic Response—The Role of HIF Protein Translation in the Cellular Response to Low Oxygen

Iglika G. Ivanova, Catherine V. Park, Niall S. Kenneth

Cells. 2019 Feb; 8(2): 114. Published online 2019 Feb 1. doi: 10.3390/cells8020114

PMCID:: PMC6406544

Article PDF–561K

Select item 640113916.

Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2

Jae Eun Lee, Seung-Hyun Shin, Hyun-Woo Shin, Yang-Sook Chun, Jong-Wan Park

Sci Rep. 2019; 9: 3480. Published online 2019 Mar 5. doi: 10.1038/s41598-019-39843-6

PMCID:: PMC6401139

Article PDF–1.9M

Select item 627692217.

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

Xia Ke, Fei Fei, Yanke Chen, Li Xu, Zheng Zhang, Qichao Huang, Hongxin Zhang, Hushan Yang, Zhinan Chen, Jinliang Xing

Carcinogenesis. 2012 Aug; 33(8): 1598–1607. Published online 2012 Jun 7. doi: 10.1093/carcin/bgs196

PMCID:: PMC6276922

Article PDF–5.2M

Select item 604201918.

Gene Expression Variability in Subcutaneous and Omental Adipose Tissue of Obese Men

Yonghua Zhang, Yohan Bossé, Picard Marceau, Simon Biron, Stephan Lebel, Denis Richard, Marie-Claude Vohl, André Tchernof

Gene Expr. 2007; 14(1): 35–46. Published online 2018 Jul 12. doi: 10.3727/000000007783991772

PMCID:: PMC6042019

Article PDF–107K

Select item 603741419.

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

Ming Luo, Li Shang, Michael D. Brooks, Evelyn Jiagge, Yongyou Zhu, Johanna M. Buschhaus, Sarah Conley, Melissa A. Fath, April Davis, Elizabeth Gheordunescu, Yongfang Wang, Ramdane Harouaka, Ann Lozier, Daniel Triner, Sean McDermott, Sofia D. Merajver, Gary D. Luker, Douglas R. Spitz, Max S. Wicha

Cell Metab. Author manuscript; available in PMC 2019 Jul 3.

Published in final edited form as: Cell Metab. 2018 Jul 3; 28(1): 69–86.e6. doi: 10.1016/j.cmet.2018.06.006

PMCID:: PMC6037414

Article PDF–2.4M

Select item 596134920.

The number of titrated microRNA species dictates ceRNA regulation

Hua-Sheng Chiu, María Rodríguez Martínez, Elena V . Komissarova, David Llobet-Navas, Mukesh Bansal, Evan O Paull, José Silva, Xuerui Yang, Pavel Sumazin, Andrea Califano

Nucleic Acids Res. 2018 May 18; 46(9): 4354–4369. Published online 2018 Apr 19. doi: 10.1093/nar/gky286