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Items: 1 to 20 of 500

1.
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.
L Lennard, B E Gibson, T Nicole, J S Lilleyman
Arch Dis Child. 1993 Nov; 69(5): 577–579. doi: 10.1136/adc.69.5.577
PMCID:
PMC1029622
SummaryPage BrowsePDF–518K
2.
Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency
Debbie S. Deben, Luc J. J. Derijks, Bianca J. C. van den Bosch, Rob H. Creemers, Annick van Nunen, Adriaan A. van Bodegraven, Dennis R. Wong
Metabolites. 2023 Oct; 13(10): 1054. Published online 2023 Oct 6. doi: 10.3390/metabo13101054
PMCID:
PMC10608562
AbstractArticlePDF–918K
3.
Case Report: Multifocal EBV-Associated Diffuse Large B-Cell Lymphoma in a Patient With 6-MP Associated Lymphopenia With TPMT Deficiency
Lara Müller-Scholden, Frank Deinlein, Matthias Eyrich, Paul Gerhardt Schlegel, Verena Wiegering, Matthias Wölfl
Front Pediatr. 2022; 10: 881612. Published online 2022 May 6. doi: 10.3389/fped.2022.881612
PMCID:
PMC9120811
AbstractArticlePDF–911K
4.
Two cases of thiopurine methyltransferase (TPMT) deficiency – a lucky save and a near miss with azathioprine
Sharon J Gardiner, Richard B Gearry, Murray L Barclay, Evan J Begg
Br J Clin Pharmacol. 2006 Oct; 62(4): 473–476. Published online 2005 Aug 1. doi: 10.1111/j.1365-2125.2005.02474.x
PMCID:
PMC1885160
AbstractArticlePDF–123K
5.
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
H. L. Tai, E. Y. Krynetski, C. R. Yates, T. Loennechen, M. Y. Fessing, N. F. Krynetskaia, W. E. Evans
Am J Hum Genet. 1996 Apr; 58(4): 694–702.
PMCID:
PMC1914689
SummaryPage BrowsePDF–1.9M
6.
Transporter-Mediated Protection Against Thiopurine-Induced Hematopoietic Toxicity
Partha Krishnamurthy, Matthias Schwab, Kazumasa Takenaka, Deepa Nachagari, Jessica Morgan, Mark Leslie, Weinan Du, Kelli Boyd, Meyling Cheok, Hiromitsu Nakauchi, Catia Marzolini, Richard B. Kim, Balasubramanian Poonkuzhali, Erin Schuetz, William Evans, Mary Relling, John Schuetz
Cancer Res. Author manuscript; available in PMC 2012 Apr 10.
Published in final edited form as: Cancer Res. 2008 Jul 1; 68(13): 4983–4989. doi: 10.1158/0008-5472.CAN-07-6790
PMCID:
PMC3323115
AbstractArticlePDF–1.3M
7.
Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier
Yitian Zhou, Carolina Dagli Hernandez, Volker M. Lauschke
Br J Cancer. 2020 Dec 8; 123(12): 1782–1789. Published online 2020 Sep 25. doi: 10.1038/s41416-020-01084-0
PMCID:
PMC7722893
AbstractArticlePDF–612K
8.
Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity
Chengcheng Liu, Laura J. Janke, Jun J. Yang, William E. Evans, John D Schuetz, Mary V. Relling
Cancer Chemother Pharmacol. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2017 Aug; 80(2): 287–293. Published online 2017 Jun 16. doi: 10.1007/s00280-017-3361-2
PMCID:
PMC5628515
AbstractArticlePDF–464K
9.
Neutrophil extracellular traps modulate inflammatory markers and uptake of oxidized LDL by human and murine macrophages
Andreas Conforti, Thorsten Wahlers, Adnana Paunel-Görgülü
PLoS One. 2021; 16(11): e0259894. Published online 2021 Nov 19. doi: 10.1371/journal.pone.0259894
PMCID:
PMC8604363
AbstractArticlePDF–1.5M
10.
A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs
Marzena Skrzypczak-Zielinska, Pawel Borun, Anna Bartkowiak-Kaczmarek, Oliwia Zakerska-Banaszak, Michal Walczak, Agnieszka Dobrowolska, Mateusz Kurzawski, Malgorzata Waszak, Daniel Lipinski, Andrzej Plawski, Ryszard Slomski
Mol Diagn Ther. 2016; 20(5): 493–499. Published online 2016 Jun 15. doi: 10.1007/s40291-016-0217-0
PMCID:
PMC5021755
AbstractArticlePDF–1.2M
11.
Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy
RM Zur, LM Roy, S Ito, J Beyene, C Carew, WJ Ungar
Pharmacogenomics J. Author manuscript; available in PMC 2016 Sep 1.
Published in final edited form as: Pharmacogenomics J. 2016 Aug; 16(4): 305–311. Published online 2016 May 24. doi: 10.1038/tpj.2016.37
PMCID:
PMC4957983
AbstractArticlePDF–553K
12.
The Outlier in All of Us: Why Implementing Pharmacogenomics Could Matter for Everyone
Peter H. O’Donnell, Keith Danahey, Mark J. Ratain
Clin Pharmacol Ther. Author manuscript; available in PMC 2017 Apr 1.
Published in final edited form as: Clin Pharmacol Ther. 2016 Apr; 99(4): 401–404. Published online 2016 Feb 15. doi: 10.1002/cpt.333
PMCID:
PMC4830348
AbstractArticlePDF–209K
13.
Implementation of TPMT testing
Lynne Lennard
Br J Clin Pharmacol. 2014 Apr; 77(4): 704–714. Published online 2014 Mar 20. doi: 10.1111/bcp.12226
PMCID:
PMC3971986
AbstractArticlePDF–873K
14.
High-Resolution Melting Analysis of the TPMT Gene: A Study in the Polish Population
Marzena Skrzypczak-Zielinska, Pawel Borun, Katarzyna Milanowska, Ludwika Jakubowska-Burek, Oliwia Zakerska, Agnieszka Dobrowolska-Zachwieja, Andrzej Plawski, Ursula G. Froster, Marlena Szalata, Ryszard Slomski
Genet Test Mol Biomarkers. 2013 Feb; 17(2): 153–159. doi: 10.1089/gtmb.2012.0192
PMCID:
PMC3552168
AbstractArticlePDF–395K
15.
TPMT Genetic Variations in Populations of the Russian Federation
Elena V Samochatova, Natalia V Chupova, Anastassia Rudneva, Olga Makarova, Tatyana V Nasedkina, Olga E Fedorova, Andrei S Glotov, Zh. Kozhekbaeva, Olga A Maiorova, Alexander G Roumyantsev, Eugene Y Krynetski, Natalia F Krynetskaia, William E Evans, Raul C Ribeiro
Pediatr Blood Cancer. Author manuscript; available in PMC 2010 Feb 1.
Published in final edited form as: Pediatr Blood Cancer. 2009 Feb; 52(2): 203–208. doi: 10.1002/pbc.21837
PMCID:
PMC2794198
AbstractArticlePDF–338K
16.
Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease
U Hindorf, M Lindqvist, C Peterson, P Söderkvist, M Ström, H Hjortswang, A Pousette, S Almer
Gut. 2006 Oct; 55(10): 1423–1431. doi: 10.1136/gut.2005.074930
PMCID:
PMC1856436
AbstractArticlePDF–302K
17.
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
E Y Krynetski, J D Schuetz, A J Galpin, C H Pui, M V Relling, W E Evans
Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4): 949–953. doi: 10.1073/pnas.92.4.949
PMCID:
PMC42614
SummaryPage BrowsePDF–1.2M
18.
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT∗3A, TPMT∗2): Mechanisms for the genetic polymorphism of TPMT activity
Hung-Liang Tai, Eugene Y. Krynetski, Erin G. Schuetz, Yuri Yanishevski, William E. Evans
Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12): 6444–6449. doi: 10.1073/pnas.94.12.6444
PMCID:
PMC21069
AbstractArticlePDF–793K
19.
Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients
Yoomi Park, Hyery Kim, Jung Yoon Choi, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Ho Joon Im, Hyoung Jin Kang, Ju Han Kim
Front Pharmacol. 2019; 10: 654. Published online 2019 Jun 11. doi: 10.3389/fphar.2019.00654
PMCID:
PMC6580331
AbstractArticlePDF–1.9M
20.
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta‐Blocker Therapy
Julio D. Duarte, Cameron D. Thomas, Craig R. Lee, Rachel Huddart, Jose A. G. Agundez, Jordan F. Baye, Andrea Gaedigk, Teri E. Klein, David E. Lanfear, Andrew A. Monte, Mohamed Nagy, Matthias Schwab, C. Michael Stein, Chakradhara Rao S. Uppugunduri, Ron H. N. van Schaik, Roseann S. Donnelly, Kelly E. Caudle, Jasmine A. Luzum
Clin Pharmacol Ther. 2024 Oct; 116(4): 939–947. Published online 2024 Jul 1. doi: 10.1002/cpt.3351
PMCID:
PMC11502236
AbstractArticlePDF–335K

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