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Items: 1 to 20 of 254

1.
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants
Letícia Tiburcio Ferreira, Gustavo Capatti Cassiano, Luis Carlos Salazar Alvarez, John Okombo, Juliana Calit, Diana Fontinha, Eva Gil-Iturbe, Rachael Coyle, Carolina Horta Andrade, Per Sunnerhagen, Daniel Youssef Bargieri, Miguel Prudêncio, Matthias Quick, Pedro V. Cravo, Marcus C. S. Lee, David A. Fidock, Fabio Trindade Maranhão Costa
PLoS Pathog. 2024 Oct; 20(10): e1012627. Published online 2024 Oct 29. doi: 10.1371/journal.ppat.1012627
PMCID:
PMC11521309
AbstractArticlePDF–2.8M
2.
Mechanistic insights and in vivo efficacy of thiosemicarbazones against methicillin-resistant Staphylococcus aureus
Avery Gaudreau, David W. Watson, Ronald S. Flannagan, Paroma Roy, Chenfangfei Shen, Ahmed Abdelmoneim, William N. Beavers, Elizabeth R. Gillies, Omar M. El-Halfawy, David E. Heinrichs
J Biol Chem. 2024 Oct; 300(10): 107689. Published online 2024 Aug 17. doi: 10.1016/j.jbc.2024.107689
PMCID:
PMC11492055
AbstractArticlePDF–2.8M
3.
Definition of Synovial Mesenchymal Stem Cells for Meniscus Regeneration by the Mechanism of Action and General Amp1200 Gene Expression
Kentaro Nakamura, Tsukasa Kitahashi, Ryo Kogawa, Yuichi Yoshino, Izumi Ogura
Int J Mol Sci. 2024 Oct; 25(19): 10510. Published online 2024 Sep 29. doi: 10.3390/ijms251910510
PMCID:
PMC11476826
AbstractArticlePDF–5.5M
4.
The moa footprints from the Pliocene – early Pleistocene of Kyeburn, Otago, New Zealand
Kane Fleury, Emma Burns, Marcus D. Richards, Kevin Norton, Stephen Read, Rachel Wesley, R. Ewan Fordyce, Klaus Wilcken
J R Soc N Z. 2024; 54(5): 620–642. Published online 2023 Nov 14. doi: 10.1080/03036758.2023.2264789
PMCID:
PMC11459810
AbstractArticlePDF–3.7M
5.
Utility of Cry1Ja for Transgenic Insect Control
John P. Mathis, Catherine Clark, Amit Sethi, Benchie Ortegon, Gilda Rauscher, Russ Booth, Samuel Coder, Mark E. Nelson
Toxins (Basel) 2024 Sep; 16(9): 384. Published online 2024 Sep 4. doi: 10.3390/toxins16090384
PMCID:
PMC11435796
AbstractArticlePDF–1.5M
6.
A multi-biomarker micronucleus assay using imaging flow cytometry
Danielle S. G. Harte, Anthony M. Lynch, Jatin Verma, Paul Rees, Andrew Filby, John W. Wills, George E. Johnson
Arch Toxicol. 2024; 98(9): 3137–3153. Published online 2024 Jul 12. doi: 10.1007/s00204-024-03801-7
PMCID:
PMC11324684
AbstractArticlePDF–1.8M
7.
A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration techniques
Louison Fresnais, Olivier Perin, Anne Riu, Romain Grall, Alban Ott, Bernard Fromenty, Jean-Clément Gallardo, Maximilian Stingl, Clément Frainay, Fabien Jourdan, Nathalie Poupin
BMC Bioinformatics. 2024; 25: 234. Published online 2024 Jul 11. doi: 10.1186/s12859-024-05845-z
PMCID:
PMC11238488
AbstractArticlePDF–2.5M
8.
Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma
Zongze He, Yu Peng, Duo Wang, Chen Yang, Chengzhi Zhou, Bo Gong, Siyuan Song, Yi Wang
Front Immunol. 2024; 15: 1427200. Published online 2024 Jun 26. doi: 10.3389/fimmu.2024.1427200
PMCID:
PMC11233524
AbstractArticlePDF–14M
9.
Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes
Melissa M Heintz, William D Klaren, Alexander W East, Laurie C Haws, Steven R McGreal, Rebecca R Campbell, Chad M Thompson
Toxicol Sci. 2024 Jul; 200(1): 165–182. Published online 2024 Apr 4. doi: 10.1093/toxsci/kfae044
PMCID:
PMC11199992
AbstractArticlePDF–3.3M
10.
Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes
Melissa M Heintz, William D Klaren, Alexander W East, Laurie C Haws, Steven R McGreal, Rebecca R Campbell, Chad M Thompson
Toxicol Sci. 2024 Jul; 200(1): 183–198. Published online 2024 Apr 4. doi: 10.1093/toxsci/kfae045
PMCID:
PMC11199908
AbstractArticlePDF–2.6M
11.
In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells
Juan Carlos Jado, Michelle Dow, Krypton Carolino, Adam Klie, Gregory J. Fonseca, Trey Ideker, Hannah Carter, Elizabeth A. Winzeler
Sci Rep. 2024; 14: 13989. Published online 2024 Jun 18. doi: 10.1038/s41598-024-63943-7
PMCID:
PMC11183241
AbstractArticlePDF–3.2M
12.
Intervention effects of telenursing based on M-O-A model in empty-nest older adult individuals with chronic diseases: a randomized controlled trial
Yuan Yuan, Ping Hou, Sican Wang, Akio Kitayama, Kiyoko Yanagihara, Jingyan Liang
Front Public Health. 2024; 12: 1239445. Published online 2024 May 29. doi: 10.3389/fpubh.2024.1239445
PMCID:
PMC11168200
AbstractArticlePDF–1.5M
13.
Research on Gas Multi-indicator Warning Method of Coal Mine Working Face Based on MOA-Transformer
Huan Yang, Jian Wang, Haoliang Zhang
ACS Omega. 2024 May 21; 9(20): 22136–22144. Published online 2024 May 7. doi: 10.1021/acsomega.4c00519
PMCID:
PMC11112559
AbstractArticlePDF–3.0M
14.
A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered
Evangeline R Jackson, Mika L Persson, Cameron J Fish, Izac J Findlay, Sabine Mueller, Javad Nazarian, Esther Hulleman, Jasper van der Lugt, Ryan J Duchatel, Matthew D Dun
Neuro Oncol. 2024 Apr; 26(Suppl 2): S136–S154. Published online 2023 Aug 17. doi: 10.1093/neuonc/noad144
PMCID:
PMC11066926
AbstractArticlePDF–7.2M
15.
A novel dual mechanism-of-action bispecific PD-1-IL-2v armed by a “βγ-only” interleukin-2 variant
Yongji Jiang, Chuyuan Chen, Yuan Liu, Rong Wang, Chuan Feng, Lili Cai, Shuang Chang, Lei Zhao
Front Immunol. 2024; 15: 1369376. Published online 2024 Apr 4. doi: 10.3389/fimmu.2024.1369376
PMCID:
PMC11024467
AbstractArticlePDF–2.3M
16.
Modes of action and potential as a peptide‐based biofungicide of a plant defensin MtDef4
Hui Li, Raviraj Kalunke, Meenakshi Tetorya, Kirk J. Czymmek, Dilip M. Shah
Mol Plant Pathol. 2024 Apr; 25(4): e13458. Published online 2024 Apr 15. doi: 10.1111/mpp.13458
PMCID:
PMC11018249
AbstractArticlePDF–14M
17.
Thwarting resistance: MgrA inhibition with methylophiopogonanone a unveils a new battlefront against S. aureus
Xuerui Guo, Li Wang, Jinlong Zhang, Quan Liu, Bingmei Wang, Da Liu, Fei Gao, Gongga Lanzi, Yicheng Zhao, Yan Shi
NPJ Biofilms Microbiomes. 2024; 10: 15. Published online 2024 Feb 27. doi: 10.1038/s41522-024-00485-w
PMCID:
PMC10899606
AbstractArticlePDF–3.1M
18.
Organic Synthesis and Current Understanding of the Mechanisms of CFTR Modulator Drugs Ivacaftor, Tezacaftor, and Elexacaftor
Filipa C. Ferreira, Camilla D. Buarque, Miquéias Lopes-Pacheco
Molecules. 2024 Feb; 29(4): 821. Published online 2024 Feb 10. doi: 10.3390/molecules29040821
PMCID:
PMC10891718
AbstractArticlePDF–6.2M
19.
Mediators of the effects of exercise and manual therapy for people with knee and hip osteoarthritis: A secondary, exploratory analysis of the MOA trial
Daniel Cury Ribeiro, Sarah E. Lamb, J. Haxby Abbott
Osteoarthr Cartil Open. 2024 Mar; 6(1): 100431. Published online 2024 Jan 9. doi: 10.1016/j.ocarto.2023.100431
PMCID:
PMC10832273
AbstractArticlePDF–506K
20.
CDS-DB, an omnibus for patient-derived gene expression signatures induced by cancer treatment
Zhongyang Liu, Ruzhen Chen, Lele Yang, Jianzhou Jiang, Shurui Ma, Lanhui Chen, Mengqi He, Yichao Mao, Congcong Guo, Xiangya Kong, Xinlei Zhang, Yaning Qi, Fengsong Liu, Fuchu He, Dong Li
Nucleic Acids Res. 2024 Jan 5; 52(D1): D1163–D1179. Published online 2023 Oct 27. doi: 10.1093/nar/gkad888
PMCID:
PMC10767794
AbstractArticlePDF–2.7M

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