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Select item 110337261.

ACOD1, rather than itaconate, facilitates p62‐mediated activation of Nrf2 in microglia post spinal cord contusion

Zhanyang Qian, Mingjie Xia, Tianyu Zhao, You Li, Guangshen Li, Yanan Zhang, Haijun Li, Lei Yang

Clin Transl Med. 2024 Apr; 14(4): e1661. Published online 2024 Apr 22. doi: 10.1002/ctm2.1661

PMCID:: PMC11033726

Abstract Article PDF–15M

Select item 110096552.

The IRG1–itaconate axis protects from cholesterol-induced inflammation and atherosclerosis

Yannick Cyr, Fazli K. Bozal, José Gabriel Barcia Durán, Alexandra A. C. Newman, Letizia Amadori, Panagiotis Smyrnis, Morgane Gourvest, Dayasagar Das, Michael Gildea, Ravneet Kaur, Tracy Zhang, Kristin M. Wang, Richard Von Itter, P. Martin Schlegel, Samantha D. Dupuis, Bernard F. Sanchez, Ann Marie Schmidt, Edward A. Fisher, Coen van Solingen, Chiara Giannarelli, Kathryn J. Moore

Proc Natl Acad Sci U S A. 2024 Apr 9; 121(15): e2400675121. Published online 2024 Apr 2. doi: 10.1073/pnas.2400675121

PMCID:: PMC11009655

Abstract Article PDF–5.3M

Select item 109817073.

Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour

Nat Commun. 2024; 15: 2803. Published online 2024 Mar 30. doi: 10.1038/s41467-024-47096-9

PMCID:: PMC10981707

Abstract Article PDF–3.0M

Select item 109623124.

The Parkinson’s disease kinase LRRK2 coordinates a cell intrinsic defense pathway against the intracellular pathogen Salmonella

Huan Lian, Donghyun Park, Meixin Chen, Florian Schueder, Maria Lara-Tejero, Jun Liu, Jorge E. Galán

Nat Microbiol. Author manuscript; available in PMC 2024 Mar 25.

Published in final edited form as: Nat Microbiol. 2023 Oct; 8(10): 1880–1895. Published online 2023 Aug 28. doi: 10.1038/s41564-023-01459-y

PMCID:: PMC10962312

Abstract Article PDF–5.5M

Select item 109572225.

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

Weiwei Shi, Tiffany J. Cassmann, Aditya Vijay Bhagwate, Taro Hitosugi, W.K. Eddie Ip

Cell Rep. Author manuscript; available in PMC 2024 Mar 21.

Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113746. Published online 2024 Feb 7. doi: 10.1016/j.celrep.2024.113746

PMCID:: PMC10957222

Abstract Article PDF–3.3M

Select item 109176606.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108345937.

ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota

Tanja Eberhart, Federico Uchenna Stanley, Luisa Ricci, Tiziana Chirico, Roberto Ferrarese, Sofia Sisti, Alessandra Scagliola, Andreina Baj, Sylvia Badurek, Andreas Sommer, Rachel Culp-Hill, Monika Dzieciatkowska, Engy Shokry, David Sumpton, Angelo D’Alessandro, Nicola Clementi, Nicasio Mancini, Simone Cardaci

Cell Death Dis. 2024 Feb; 15(2): 105. Published online 2024 Feb 1. doi: 10.1038/s41419-024-06483-2

PMCID:: PMC10834593

Abstract Article PDF–6.1M

Select item 107104088.

Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8⁺ T-cell exhaustion

Xuemei Gu, Haoran Wei, Caixia Suo, Shengqi Shen, Chuxu Zhu, Liang Chen, Kai Yan, Zhikun Li, Zhenhua Bian, Pinggen Zhang, Mengqiu Yuan, Yingxuan Yu, Jinzhi Du, Huafeng Zhang, Linchong Sun, Ping Gao

Nat Commun. 2023; 14: 8154. Published online 2023 Dec 9. doi: 10.1038/s41467-023-43988-4

PMCID:: PMC10710408

Abstract Article PDF–4.9M

Select item 106195009.

Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

Janna L. Crossley, Sonya Ostashevskaya-Gohstand, Stefano Comazzetto, Jessica S. Hook, Lei Guo, Neda Vishlaghi, Conan Juan, Lin Xu, Alexander R. Horswill, Gerta Hoxhaj, Jessica G. Moreland, Robert J. Tower, Benjamin Levi

JCI Insight. 2023 Oct 23; 8(20): e169208. Published online 2023 Oct 23. doi: 10.1172/jci.insight.169208

PMCID:: PMC10619500

Abstract Article PDF–2.4M

Select item 1059336110.

Myeloid-derived Itaconate Suppresses Cytotoxic CD8⁺ T Cells and Promotes Tumor Growth

Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Tengjia Jiang, Austin Y. Feng, Yaqing Zhang, Dennie T. Frederick, Lei Gu, Li Cai, John M. Asara, Marina Pasca di Magliano, Genevieve M Boland, Keith T. Flaherty, Kenneth D. Swanson, David Liu, Joshua D. Rabinowitz, Bin Zheng

Nat Metab. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Nat Metab. 2022 Dec; 4(12): 1660–1673. Published online 2022 Nov 14. doi: 10.1038/s42255-022-00676-9

PMCID:: PMC10593361

Abstract Article PDF–4.5M

Select item 1059045311.

An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2

Carissa K. Harvest, Taylor J. Abele, Chen Yu, Cole J. Beatty, Megan E. Amason, Zachary P. Billman, Morgan A. DePrizio, Fernando W. Souza, Carolyn A. Lacey, Vivien I. Maltez, Heather N. Larson, Benjamin D. McGlaughon, Daniel R. Saban, Stephanie A. Montgomery, Edward A. Miao

Nat Commun. 2023; 14: 6686. Published online 2023 Oct 21. doi: 10.1038/s41467-023-42218-1

PMCID:: PMC10590453

Abstract Article PDF–14M

Select item 1051714112.

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis

Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou, Kaiwei Jia, Suyuan Wang, Mu Wang, Yunhui Li, Shudan Luo, Shan Lu, Yiwen Fan, Dingji Zhang, Yingyun Yang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou

Cell Death Dis. 2023 Sep; 14(9): 625. Published online 2023 Sep 22. doi: 10.1038/s41419-023-06155-7

PMCID:: PMC10517141

Abstract Article PDF–5.9M

Select item 1037428113.

Succinate mediates inflammation-induced adrenocortical dysfunction

Ivona Mateska, Anke Witt, Eman Hagag, Anupam Sinha, Canelif Yilmaz, Evangelia Thanou, Na Sun, Ourania Kolliniati, Maria Patschin, Heba Abdelmegeed, Holger Henneicke, Waldemar Kanczkowski, Ben Wielockx, Christos Tsatsanis, Andreas Dahl, Axel Karl Walch, Ka Wan Li, Mirko Peitzsch, Triantafyllos Chavakis, Vasileia Ismini Alexaki

eLife. 2023; 12: e83064. Published online 2023 Jul 14. doi: 10.7554/eLife.83064

PMCID:: PMC10374281

Abstract Article PDF–8.3M

Select item 1035497714.

Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression

Linxi Lv, Hui Jiang, Dianze Song, Xiaoqin Zhou, Feng Chen, Long Ren, Yongen Xie, Mei Zeng

Arthritis Res Ther. 2023; 25: 121. Published online 2023 Jul 19. doi: 10.1186/s13075-023-03107-6

PMCID:: PMC10354977

Abstract Article PDF–22M

Select item 1029321315.

Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1

Fangfang Chen, Israfil Yalcin, Mingming Zhao, Chutao Chen, Wulf Blankenfeldt, Frank Pessler, Konrad Büssow

Sci Rep. 2023; 13: 10360. Published online 2023 Jun 26. doi: 10.1038/s41598-023-37373-w

PMCID:: PMC10293213

Abstract Article PDF–2.2M

Select item 1020271416.

Deficiency of IRG1/ itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice

Jing-Huan Qiu, Li Zhang, Ke-Xin Li, Qiu-Hong Zhang, Ke-Rui Fan, Kun Chen, Yu Jiang, Gang Liu

Exp Anim. 2023; 72(2): 164–172. Published online 2022 Oct 26. doi: 10.1538/expanim.22-0104

PMCID:: PMC10202714

Abstract Article PDF–4.7M

Select item 1014689217.

Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy

Yu-Jia Chen, Guan-Nan Li, Xian-Jing Li, Lin-Xing Wei, Min-Jie Fu, Zhou-Li Cheng, Zhen Yang, Gui-Qi Zhu, Xu-Dong Wang, Cheng Zhang, Jin-Ye Zhang, Yi-Ping Sun, Hexige Saiyin, Jin Zhang, Wei-Ren Liu, Wen-Wei Zhu, Kun-Liang Guan, Yue Xiong, Yong Yang, Dan Ye, Lei-Lei Chen

Sci Adv. 2023 Apr; 9(17): eadg0654. Published online 2023 Apr 28. doi: 10.1126/sciadv.adg0654

PMCID:: PMC10146892

Abstract Article PDF–2.8M

Select item 992004518.

Cepharanthine Alleviates DSS-Induced Ulcerative Colitis via Regulating Aconitate Decarboxylase 1 Expression and Macrophage Infiltration

Min-Na Zhang, Rui Xie, Hong-Gang Wang, Xin Wen, Jing-Yi Wang, Le He, Meng-Hui Zhang, Xiao-Zhong Yang

Molecules. 2023 Feb; 28(3): 1060. Published online 2023 Jan 20. doi: 10.3390/molecules28031060

PMCID:: PMC9920045

Abstract Article PDF–2.6M

Select item 990639519.

Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever

Lisa Kohl, Md Nur A Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Ölke, Elisabeth Liebler‐Tenorio, Jan Schulze‐Luehrmann, Michael Mauermeir, Kai‐Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Krönke, Peter J Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens‐Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Lührmann, Roland Lang

EMBO Mol Med. 2023 Feb; 15(2): e15931. Published online 2022 Dec 7. doi: 10.15252/emmm.202215931

PMCID:: PMC9906395

Abstract Article PDF–1.4M

Select item 974438420.

Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages

Wei He, Antonia Henne, Mario Lauterbach, Eike Geißmar, Fabian Nikolka, Celia Kho, Alexander Heinz, Catherine Dostert, Melanie Grusdat, Thekla Cordes, Janika Härm, Oliver Goldmann, Anouk Ewen, Charlène Verschueren, Julia Blay-Cadanet, Robert Geffers, Hendrikus Garritsen, Manfred Kneiling, Christian K. Holm, Christian M. Metallo, Eva Medina, Zeinab Abdullah, Eicke Latz, Dirk Brenner, Karsten Hiller

Nat Metab. Author manuscript; available in PMC 2023 Jun 2.

Published in final edited form as: Nat Metab. 2022 May; 4(5): 524–533. Published online 2022 Jun 2. doi: 10.1038/s42255-022-00565-1

PMCID:: PMC9744384

Abstract Article PDF–3.6M

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