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Select item 111451241.

SIRT1 mediates the excitability of spinal CaMKIIα‐positive neurons and participates in neuropathic pain by controlling Nav1.3

Yuanzeng Wang, Yidan Zhang, Nan Ma, Wen Zhao, Xiuhua Ren, Yanyan Sun, Weidong Zang, Jing Cao

CNS Neurosci Ther. 2024 Jun; 30(6): e14764. Published online 2024 Jun 3. doi: 10.1111/cns.14764

PMCID:: PMC11145124

Abstract Article PDF–24M

Select item 109579242.

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of Na_V1.2 and Na_V1.6

Luis Manuel Arratia, Juan David Bermudes-Contreras, Jorge Armando Juarez-Monroy, Erik Alan Romero-Macías, Julio Cesar Luna-Rojas, Marisol López-Hidalgo, Ana Victoria Vega, Absalom Zamorano-Carrillo

Sci Rep. 2024; 14: 6761. Published online 2024 Mar 21. doi: 10.1038/s41598-024-57117-8

PMCID:: PMC10957924

Abstract Article PDF–4.0M

Select item 107941513.

Na_v1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

Wenyu Fu, Dmytro Vasylyev, Yufei Bi, Mingshuang Zhang, Guodong Sun, Asya Khleborodova, Guiwu Huang, Libo Zhao, Renpeng Zhou, Yonggang Li, Shujun Liu, Xianyi Cai, Wenjun He, Min Cui, Xiangli Zhao, Aubryanna Hettinghouse, Julia Good, Ellen Kim, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Edward X. Guo, Jonathan Samuels, Wenhuo Hu, Mukundan Attur, Stephen G. Waxman, Chuan-ju Liu

Nature. 2024; 625(7995): 557–565. Published online 2024 Jan 3. doi: 10.1038/s41586-023-06888-7

PMCID:: PMC10794151

Abstract Article PDF–85M

Select item 107693504.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 107577375.

Evaluating the interplay between estrous cyclicity and flurothyl-induced seizure susceptibility in Scn2a ^K1422E mice

Dennis M. Echevarria-Cooper, Jennifer A. Kearney

MicroPubl Biol. 2023; 2023: 10.17912/micropub.biology.000850. Published online 2023 Dec 16. doi: 10.17912/micropub.biology.000850

PMCID:: PMC10757737

Abstract Article PDF–670K

Select item 107556406.

Dynamic Foraging Behavior Performance Is Not Affected by Scn2a Haploinsufficiency

Selin Schamiloglu, Hao Wu, Mingkang Zhou, Alex C. Kwan, Kevin J. Bender

eNeuro. 2023 Dec; 10(12): ENEURO.0367-23.2023. Published online 2023 Dec 8. doi: 10.1523/ENEURO.0367-23.2023

PMCID:: PMC10755640

Abstract Article PDF–644K

Select item 102721397.

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice

Hyoseon Oh, Suho Lee, Yusang Oh, Seongbin Kim, Young Seo Kim, Yeji Yang, Woochul Choi, Ye-Eun Yoo, Heejin Cho, Seungjoon Lee, Esther Yang, Wuhyun Koh, Woojin Won, Ryunhee Kim, C. Justin Lee, Hyun Kim, Hyojin Kang, Jin Young Kim, Taeyun Ku, Se-Bum Paik, Eunjoon Kim

Nat Commun. 2023; 14: 3547. Published online 2023 Jun 15. doi: 10.1038/s41467-023-39203-z

PMCID:: PMC10272139

Abstract Article PDF–4.3M

Select item 101713598.

Na_v 1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation

Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf

Exp Neurol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Neurol. 2023 Jun; 364: 114393. Published online 2023 Mar 30. doi: 10.1016/j.expneurol.2023.114393

PMCID:: PMC10171359

Abstract Article PDF–1.9M

Select item 101479239.

Pain-causing stinging nettle toxins target TMEM233 to modulate Na_V1.7 function

Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter

Nat Commun. 2023; 14: 2442. Published online 2023 Apr 28. doi: 10.1038/s41467-023-37963-2

PMCID:: PMC10147923

Abstract Article PDF–3.8M

Select item 958654710.

Na_v1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann, Allison M Barry, Andrew Marshall, Michael Lee, Leah M Mayo, Manon Bohic, Georgios Baskozos, India Morrison, Line S Löken, Sarah McIntyre, Saad S Nagi, Roland Staud, Isac Sehlstedt, Richard D Johnson, Johan Wessberg, John N Wood, Christopher G Woods, Aziz Moqrich, Håkan Olausson, David L Bennett

Brain. 2022 Oct; 145(10): 3637–3653. Published online 2021 Dec 27. doi: 10.1093/brain/awab482

PMCID:: PMC9586547

Abstract Article PDF–1.9M

Select item 953684211.

Selective optogenetic activation of Na_V1.7–expressing afferents in Na_V1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli

Toyoaki Maruta, Kotaro Hidaka, Satoshi Kouroki, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Seiya Mizuno, Tetsuro Shirasaka, Toshihiko Yanagita, Satoru Takahashi, Ryu Takeya, Isao Tsuneyoshi

PLoS One. 2022; 17(10): e0275751. Published online 2022 Oct 6. doi: 10.1371/journal.pone.0275751

PMCID:: PMC9536842

Abstract Article PDF–1.4M

Select item 943373012.

Cellular and behavioral effects of altered Na_V1.2 sodium channel ion permeability in Scn2a^K1422E mice

Dennis M Echevarria-Cooper, Nicole A Hawkins, Sunita N Misra, Alexandra M Huffman, Tyler Thaxton, Christopher H Thompson, Roy Ben-Shalom, Andrew D Nelson, Anna M Lipkin, Alfred L George Jr, Kevin J Bender, Jennifer A Kearney

Hum Mol Genet. 2022 Sep 1; 31(17): 2964–2988. Published online 2022 Apr 13. doi: 10.1093/hmg/ddac087

PMCID:: PMC9433730

Abstract Article PDF–2.9M

Select item 901861713.

Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms

Zhixiong Ma, Muriel Eaton, Yushuang Liu, Jingliang Zhang, Xiaoling Chen, Xinyu Tu, Yiqiang Shi, Zhefu Que, Kyle Wettschurack, Zaiyang Zhang, Riyi Shi, Yueyi Chen, Adam Kimbrough, Nadia A. Lanman, Leah Schust, Zhuo Huang, Yang Yang

Neurobiol Dis. Author manuscript; available in PMC 2023 Jun 15.

Published in final edited form as: Neurobiol Dis. 2022 Jun 15; 168: 105690. Published online 2022 Mar 14. doi: 10.1016/j.nbd.2022.105690

PMCID:: PMC9018617

Abstract Article PDF–2.0M

Select item 871964914.

Paradoxical hyperexcitability from Na_V1.2 sodium channel loss in neocortical pyramidal cells

Perry W.E. Spratt, Ryan P.D. Alexander, Roy Ben-Shalom, Atehsa Sahagun, Henry Kyoung, Caroline M. Keeshen, Stephan J. Sanders, Kevin J. Bender

Cell Rep. Author manuscript; available in PMC 2021 Dec 31.

Published in final edited form as: Cell Rep. 2021 Aug 3; 36(5): 109483. doi: 10.1016/j.celrep.2021.109483

PMCID:: PMC8719649

Abstract Article PDF–2.5M

Select item 863159915.

Antisense oligonucleotide therapy reduces seizures and extends life span in an SCN2A gain-of-function epilepsy model

Melody Li, Nikola Jancovski, Paymaan Jafar-Nejad, Lisseth E. Burbano, Ben Rollo, Kay Richards, Lisa Drew, Alicia Sedo, Jacqueline Heighway, Svenja Pachernegg, Armand Soriano, Linghan Jia, Todd Blackburn, Blaine Roberts, Alex Nemiroff, Kelley Dalby, Snezana Maljevic, Christopher A. Reid, Frank Rigo, Steven Petrou

J Clin Invest. 2021 Dec 1; 131(23): e152079. Published online 2021 Dec 1. doi: 10.1172/JCI152079

PMCID:: PMC8631599

Abstract Article PDF–4.9M

Select item 849743916.

Dissecting the precise nature of itch-evoked scratching

Nivanthika K. Wimalasena, George Milner, Ricardo Silva, Cliff Vuong, Zihe Zhang, Diana M. Bautista, Clifford J. Woolf

Neuron. Author manuscript; available in PMC 2021 Oct 8.

Published in final edited form as: Neuron. 2021 Oct 6; 109(19): 3075–3087.e2. Published online 2021 Aug 18. doi: 10.1016/j.neuron.2021.07.020

PMCID:: PMC8497439

Abstract Article PDF–1.4M

Select item 848614317.

SCN2A contributes to oligodendroglia excitability and development in the mammalian brain

Elizabeth Gould, Jun Hee Kim

Cell Rep. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Cell Rep. 2021 Sep 7; 36(10): 109653. doi: 10.1016/j.celrep.2021.109653

PMCID:: PMC8486143

Abstract Article PDF–2.2M

Select item 841005818.

Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors

Hong-Gang Wang, Charlotte C. Bavley, Anfei Li, Rebecca M. Jones, Jonathan Hackett, Yared Bayleyen, Francis S. Lee, Anjali M. Rajadhyaksha, Geoffrey S. Pitt

JCI Insight. 2021 Aug 9; 6(15): e150698. Published online 2021 Aug 9. doi: 10.1172/jci.insight.150698

PMCID:: PMC8410058

Abstract Article PDF–1.8M

Select item 838231619.

Severe deficiency of the voltage-gated sodium channel Na_V1.2 elevates neuronal excitability in adult mice

Jingliang Zhang, Xiaoling Chen, Muriel Eaton, Jiaxiang Wu, Zhixiong Ma, Shirong Lai, Anthony Park, Talha S. Ahmad, Zhefu Que, Ji Hea Lee, Tiange Xiao, Yuansong Li, Yujia Wang, Maria I. Olivero-Acosta, James A. Schaber, Krishna Jayant, Chongli Yuan, Zhuo Huang, Nadia A. Lanman, William C. Skarnes, Yang Yang

Cell Rep. Author manuscript; available in PMC 2021 Aug 23.

Published in final edited form as: Cell Rep. 2021 Aug 3; 36(5): 109495. doi: 10.1016/j.celrep.2021.109495

PMCID:: PMC8382316

Abstract Article PDF–1.7M

Select item 831323920.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

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