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Select item 108029521.

Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly

Marcos Schaan Profes, Araven Tiroumalechetty, Neel Patel, Stephanie S. Lauar, Simone Sidoli, Peri T. Kurshan

PLoS Biol. 2024 Jan; 22(1): e3002466. Published online 2024 Jan 22. doi: 10.1371/journal.pbio.3002466

PMCID:: PMC10802952

Abstract Article PDF–2.7M

Select item 107978062.

A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan

Manish Chamoli, Anand Rane, Anna Foulger, Shankar J. Chinta, Azar Asadi Shahmirzadi, Caroline Kumsta, Dhanya K. Nambiar, David Hall, Angelina Holcom, Suzanne Angeli, Minna Schmidt, Sharon Pitteri, Malene Hansen, Gordon J. Lithgow, Julie K. Andersen

Nat Aging. Author manuscript; available in PMC 2024 Jan 19.

Published in final edited form as: Nat Aging. 2023 Dec; 3(12): 1529–1543. Published online 2023 Nov 13. doi: 10.1038/s43587-023-00524-9

PMCID:: PMC10797806

Abstract Article PDF–3.4M

Select item 105997253.

Neuronal HLH-30/TFEB modulates thermoresistance and longevity in C. elegans

Louis R. Lapierre

Aging (Albany NY) 2023 Oct 15; 15(19): 9892–9893. Published online 2023 Oct 12. doi: 10.18632/aging.204849

PMCID:: PMC10599725

Abstract Article PDF–372K

Select item 105235624.

Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity

Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2221553120. Published online 2023 Sep 18. doi: 10.1073/pnas.2221553120

Correction in:: Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2318184120.

PMCID:: PMC10523562

Abstract Article PDF–1.7M

Select item 105019375.

Eicosapentaenoic acid influences the pathogenesis of Candidaalbicans in Caenorhabditiselegans via inhibition of hyphal formation and stimulation of the host immune response

N. Z. Mokoena, H. Steyn, A. Hugo, T. Dix-Peek, C. Dickens, O. M. N. Gcilitshana, O. Sebolai, J. Albertyn, C. H. Pohl

Med Microbiol Immunol. 2023; 212(5): 349–368. Published online 2023 Sep 6. doi: 10.1007/s00430-023-00777-6

PMCID:: PMC10501937

Abstract Article PDF–3.9M

Select item 104573906.

Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans

Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Côté, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S.R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki

Nat Commun. 2023; 14: 5214. Published online 2023 Aug 25. doi: 10.1038/s41467-023-40857-y

PMCID:: PMC10457390

Abstract Article PDF–3.3M

Select item 103932987.

Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

Maria I Lazaro-Pena, Adam B Cornwell, Carlos A Diaz-Balzac, Ritika Das, Zachary C Ward, Nicholas Macoretta, Juilee Thakar, Andrew V Samuelson

eLife. 2023; 12: e85792. Published online 2023 Jun 20. doi: 10.7554/eLife.85792

PMCID:: PMC10393298

Abstract Article PDF–6.8M

Select item 102877388.

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee

Nat Commun. 2023; 14: 3716. Published online 2023 Jun 22. doi: 10.1038/s41467-023-39393-6

PMCID:: PMC10287738

Abstract Article PDF–1.7M

Select item 102364459.

Increased Alcohol Dehydrogenase 1 activity promotes longevity

Abbas Ghaddar, Vinod K. Mony, Swarup Mishra, Samuel Berhanu, James C. Johnson, Elisa Enriquez-Hesles, Emma Harrison, Aaroh Patel, Mary Kate Horak, Jeffrey S. Smith, Eyleen J. O’Rourke

Curr Biol. Author manuscript; available in PMC 2024 Mar 27.

Published in final edited form as: Curr Biol. 2023 Mar 27; 33(6): 1036–1046.e6. Published online 2023 Feb 17. doi: 10.1016/j.cub.2023.01.059

PMCID:: PMC10236445

Abstract Article PDF–1.3M

Select item 1015423610.

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Wenming Huang, Chun Kew, Stephanie de Alcantara Fernandes, Anna Löhrke, Lynn Han, Constantinos Demetriades, Adam Antebi

Nat Aging. 2022; 2(9): 796–808. Published online 2022 Sep 19. doi: 10.1038/s43587-022-00275-z

PMCID:: PMC10154236

Abstract Article PDF–17M

Select item 1008652011.

Age‐dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans

Konstantinos Palikaras, Meropi Mari, Christina Ploumi, Andrea Princz, George Filippidis, Nektarios Tavernarakis

Aging Cell. 2023 Apr; 22(4): e13788. Published online 2023 Jan 31. doi: 10.1111/acel.13788

PMCID:: PMC10086520

Abstract Article PDF–2.8M

Select item 1001405212.

Neuronal HLH‐30/TFEB modulates peripheral mitochondrial fragmentation to improve thermoresistance in Caenorhabditis elegans

Shi Quan Wong, Catherine J. Ryan, Dennis M. Bonal, Joslyn Mills, Louis R. Lapierre

Aging Cell. 2023 Mar; 22(3): e13741. Published online 2022 Nov 23. doi: 10.1111/acel.13741

PMCID:: PMC10014052

Abstract Article PDF–4.9M

Select item 996893313.

C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB

Debanjan Goswamy, Xavier Gonzalez, Sid A. Labed, Javier E. Irazoqui

Front Immunol. 2023; 14: 1094145. Published online 2023 Feb 13. doi: 10.3389/fimmu.2023.1094145

PMCID:: PMC9968933

Abstract Article PDF–6.3M

Select item 996121114.

Naringin Alleviates Glucose-Induced Aging by Reducing Fat Accumulation and Promoting Autophagy in Caenorhabditis elegans

Peisen Guo, Panpan Wang, Limin Liu, Peixi Wang, Guimiao Lin, Zhi Qu, Zengli Yu, Nan Liu

Nutrients. 2023 Feb; 15(4): 907. Published online 2023 Feb 10. doi: 10.3390/nu15040907

PMCID:: PMC9961211

Abstract Article PDF–9.9M

Select item 980994815.

SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity

Chiao-Yin Lim, Huan-Ting Lin, Caroline Kumsta, Tzu-Chiao Lu, Feng-Yung Wang, Yun-Hsuan Kang, Malene Hansen, Tsui-Ting Ching, Ao-Lin Hsu

Autophagy. 2023; 19(1): 224–240. Published online 2022 May 3. doi: 10.1080/15548627.2022.2068267

PMCID:: PMC9809948

Abstract Article PDF–4.7M

Select item 964278016.

Cobalt chloride has beneficial effects across species through a hormetic mechanism

Alfonso Schiavi, Alessandra Runci, Teresa Maiorino, Francesco Davide Naso, Marta Barenys, Ellen Fritsche, Flavie Strappazzon, Natascia Ventura

Front Cell Dev Biol. 2022; 10: 986835. Published online 2022 Oct 25. doi: 10.3389/fcell.2022.986835

PMCID:: PMC9642780

Abstract Article PDF–1.7M

Select item 957002717.

Axenic Culture of Caenorhabditis elegans Alters Lysosomal/Proteasomal Balance and Increases Neuropeptide Expression

Huaihan Cai, Ping Wu, Lieselot Vandemeulebroucke, Ineke Dhondt, Madina Rasulova, Andy Vierstraete, Bart P. Braeckman

Int J Mol Sci. 2022 Oct; 23(19): 11517. Published online 2022 Sep 29. doi: 10.3390/ijms231911517

PMCID:: PMC9570027

Abstract Article PDF–6.2M

Select item 948099018.

Nutrient sensing pathways regulating adult reproductive diapause in C. elegans

Moriah Eustice, Daniel Konzman, Jeff M. Reece, Salil Ghosh, Jhullian Alston, Tyler Hansen, Andy Golden, Michelle R. Bond, Lara K. Abramowitz, John A. Hanover

PLoS One. 2022; 17(9): e0274076. Published online 2022 Sep 16. doi: 10.1371/journal.pone.0274076