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Items: 1 to 20 of 47

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
Elodie Ehret, Sévan Stroh, Muriel Auberson, Frédérique Ino, Yannick Jäger, Marc Maillard, Roman Szabo, Thomas H. Bugge, Simona Frateschi, Edith Hummler
Cells. 2023 Oct; 12(19): 2342. Published online 2023 Sep 23. doi: 10.3390/cells12192342
PMCID:
PMC10572026
AbstractArticlePDF–6.1M
3.
Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway
Toshihisa Ishii, Yoshikazu Miyasato, Masashi Ichijo, Kohei Uchimura, Fumihiko Furuya
Sci Rep. 2023; 13: 9086. Published online 2023 Jun 5. doi: 10.1038/s41598-023-36326-7
PMCID:
PMC10241893
AbstractArticlePDF–3.6M
4.
Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway
Elodie Ehret, Yannick Jäger, Chloé Sergi, Anne-Marie Mérillat, Thibaud Peyrollaz, Deepika Anand, Qing Wang, Fréderique Ino, Marc Maillard, Stephan Kellenberger, Ivan Gautschi, Roman Szabo, Thomas H. Bugge, Lotte K. Vogel, Edith Hummler, Simona Frateschi
Int J Mol Sci. 2022 Jun; 23(12): 6745. Published online 2022 Jun 16. doi: 10.3390/ijms23126745
PMCID:
PMC9224322
AbstractArticlePDF–2.9M
5.
Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity
Daniel Essigke, Bernhard N. Bohnert, Andrea Janessa, Matthias Wörn, Kingsley Omage, Hubert Kalbacher, Andreas L. Birkenfeld, Thomas H. Bugge, Roman Szabo, Ferruh Artunc
Pflugers Arch. 2022; 474(6): 613–624. Published online 2022 Mar 21. doi: 10.1007/s00424-022-02682-y
PMCID:
PMC9117342
AbstractArticlePDF–5.1M
6.
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice
Tetsuo Sekine, Soichi Takizawa, Kohei Uchimura, Asako Miyazaki, Kyoichiro Tsuchiya
Int J Mol Sci. 2021 Aug; 22(15): 8314. Published online 2021 Aug 2. doi: 10.3390/ijms22158314
PMCID:
PMC8348244
AbstractArticlePDF–3.0M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy
Roman Szabo, LuLu K. Callies, Thomas H. Bugge
Development. 2019 Nov 15; 146(22): dev183392. Published online 2019 Nov 18. doi: 10.1242/dev.183392
PMCID:
PMC6899019
AbstractArticle
9.
Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine
Makiko Kawaguchi, Koji Yamamoto, Naoki Takeda, Tsuyoshi Fukushima, Fumiki Yamashita, Katsuaki Sato, Kenichiro Kitamura, Yoshitaka Hippo, James W. Janetka, Hiroaki Kataoka
Commun Biol. 2019; 2: 11. Published online 2019 Jan 4. doi: 10.1038/s42003-018-0255-8
PMCID:
PMC6320337
AbstractArticlePDF–8.5M
10.
Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy
Roman Szabo, Thomas H. Bugge
PLoS One. 2018; 13(4): e0194660. Published online 2018 Apr 4. doi: 10.1371/journal.pone.0194660
PMCID:
PMC5884512
AbstractArticlePDF–24M
11.
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis
Marguerite S. Buzza, Tierra A. Johnson, Gregory D. Conway, Erik W. Martin, Subhradip Mukhopadhyay, Terez Shea-Donohue, Toni M. Antalis
J Biol Chem. 2017 Jun 30; 292(26): 10801–10812. Published online 2017 May 10. doi: 10.1074/jbc.M116.771469
PMCID:
PMC5491767
AbstractArticlePDF–4.1M
12.
Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases
Tsuyoshi Shuto, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Yukihiro Tasaki, Takuya Sugahara, Tomomi Ono, Chizuru Matsumoto, Yuki Sakaguchi, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Mary Ann Suico, Yoshitaka Kondo, Akihito Ishigami, Toru Takeo, Ken-ichiro Tanaka, Hiroshi Watanabe, Naomi Nakagata, Kohei Uchimura, Kenichiro Kitamura, Jian-Dong Li, Hirofumi Kai
Sci Rep. 2016; 6: 39305. Published online 2016 Dec 16. doi: 10.1038/srep39305
PMCID:
PMC5159865
AbstractArticlePDF–2.7M
13.
Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin
Roman Szabo, Taliya Lantsman, Diane E. Peters, Thomas H. Bugge
Development. 2016 Aug 1; 143(15): 2818–2828. doi: 10.1242/dev.137968
PMCID:
PMC5004911
AbstractArticle
14.
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
Martina Brunati, Simone Perucca, Ling Han, Angela Cattaneo, Francesco Consolato, Annapaola Andolfo, Céline Schaeffer, Eric Olinger, Jianhao Peng, Sara Santambrogio, Romain Perrier, Shuo Li, Marcel Bokhove, Angela Bachi, Edith Hummler, Olivier Devuyst, Qingyu Wu, Luca Jovine, Luca Rampoldi
eLife. 2015; 4: e08887. Published online 2015 Dec 17. doi: 10.7554/eLife.08887
PMCID:
PMC4755741
AbstractArticlePDF–4.1M
15.
Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin
Stine Friis, Daniel H. Madsen, Thomas H. Bugge
J Biol Chem. 2016 Feb 5; 291(6): 2577–2582. Published online 2015 Dec 30. doi: 10.1074/jbc.C115.706721
PMCID:
PMC4742728
AbstractArticlePDF–1.8M
16.
Yap and Taz are required for Ret-dependent urinary tract morphogenesis
Antoine Reginensi, Masato Hoshi, Sami Kamel Boualia, Maxime Bouchard, Sanjay Jain, Helen McNeill
Development. 2015 Aug 1; 142(15): 2696–2703. doi: 10.1242/dev.122044
PMCID:
PMC4529030
AbstractArticle
17.
The Cap1–claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation
Yongfeng Gong, Miao Yu, Jing Yang, Ernie Gonzales, Ronaldo Perez, Mingli Hou, Piyush Tripathi, Kathleen S. Hering-Smith, L. Lee Hamm, Jianghui Hou
Proc Natl Acad Sci U S A. 2014 Sep 9; 111(36): E3766–E3774. Published online 2014 Aug 25. doi: 10.1073/pnas.1406741111
PMCID:
PMC4246945
AbstractArticlePDF–1.2M
18.
Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease
Marcelo D. Carattino, Gunhild M. Mueller, Lawrence G. Palmer, Gustavo Frindt, Anna C. Rued, Rebecca P. Hughey, Thomas R. Kleyman
Am J Physiol Renal Physiol. 2014 Nov 1; 307(9): F1080–F1087. Published online 2014 Sep 10. doi: 10.1152/ajprenal.00157.2014
PMCID:
PMC4216988
AbstractArticle
19.
The retarded hair growth (rhg) mutation in mice is an allele of ornithine aminotransferase (Oat)
Jason J. Bisaillon, Legairre A. Radden, II, Eric T. Szabo, Samantha R. Hughes, Aaron M. Feliciano, Alex V. Nesta, Belinda Petrovic, Kenneth M. Palanza, Dainius Lancinskas, Theodore A. Szmurlo, David C. Artus, Martin A. Kapper, James P. Mulrooney, Thomas R. King
Mol Genet Metab Rep. 2014; 1: 378–390. Published online 2014 Sep 16. doi: 10.1016/j.ymgmr.2014.08.002
PMCID:
PMC4171744
AbstractArticlePDF–1.3M
20.
The Protease Inhibitor HAI-2, but Not HAI-1, Regulates Matriptase Activation and Shedding through Prostasin
Stine Friis, Katiuchia Uzzun Sales, Jeffrey Martin Schafer, Lotte K. Vogel, Hiroaki Kataoka, Thomas H. Bugge
J Biol Chem. 2014 Aug 8; 289(32): 22319–22332. Published online 2014 Jun 24. doi: 10.1074/jbc.M114.574400
PMCID:
PMC4139241
AbstractArticlePDF–4.6M

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