PMC Links for GEO Profiles (Select 97803635) - PMC

Maximiliano Presa, Rachel M. Bailey, Crystal Davis, Tara Murphy, Jenn Cook, Randy Walls, Hannah Wilpan, Laurent Bogdanik, Guy M. Lenk, Robert W. Burgess, Steven J. Gray, Cathleen Lutz

J Clin Invest. 2021 Jun 1; 131(11): e137159. Published online 2021 Jun 1. doi: 10.1172/JCI137159

PMCID:: PMC8159684

Abstract Article PDF–7.8M

Select item 60308995.

Protective role of the lipid phosphatase Fig4 in the adult nervous system

Yevgeniya A Mironova, Jing-Ping Lin, Ashley L Kalinski, Lucas D Huffman, Guy M Lenk, Leif A Havton, Miriam H Meisler, Roman J Giger

Hum Mol Genet. 2018 Jul 15; 27(14): 2443–2453. Published online 2018 Apr 24. doi: 10.1093/hmg/ddy145

PMCID:: PMC6030899

Abstract Article PDF–1.3M

Select item 48893286.

PI(3,5)P₂ biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

Yevgeniya A Mironova, Guy M Lenk, Jing-Ping Lin, Seung Joon Lee, Jeffery L Twiss, Ilaria Vaccari, Alessandra Bolino, Leif A Havton, Sang H Min, Charles S Abrams, Peter Shrager, Miriam H Meisler, Roman J Giger

eLife. 2016; 5: e13023. Published online 2016 Mar 23. doi: 10.7554/eLife.13023

PMCID:: PMC4889328

Abstract Article PDF–6.1M

Select item 47061177.

Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene

Guy M. Lenk, Christen M. Frei, Ashley C. Miller, Rachel C. Wallen, Yevgeniya A. Mironova, Roman J. Giger, Miriam H. Meisler

Hum Mol Genet. 2016 Jan 15; 25(2): 340–347. Published online 2015 Nov 24. doi: 10.1093/hmg/ddv480

PMCID:: PMC4706117

Abstract Article PDF–543K

Select item 42750708.

Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy

Ilaria Vaccari, Antonietta Carbone, Stefano Carlo Previtali, Yevgeniya A. Mironova, Valeria Alberizzi, Roberta Noseda, Cristina Rivellini, Francesca Bianchi, Ubaldo Del Carro, Maurizio D'Antonio, Guy M. Lenk, Lawrence Wrabetz, Roman J. Giger, Miriam H. Meisler, Alessandra Bolino

Hum Mol Genet. 2015 Jan 15; 24(2): 383–396. Published online 2014 Sep 3. doi: 10.1093/hmg/ddu451

PMCID:: PMC4275070

Abstract Article PDF–1.8M

Select item 38929699.

Jab1 regulates Schwann cell proliferation and axonal sorting through p27

Emanuela Porrello, Cristina Rivellini, Giorgia Dina, Daniela Triolo, Ubaldo Del Carro, Daniela Ungaro, Martina Panattoni, Maria Laura Feltri, Lawrence Wrabetz, Ruggero Pardi, Angelo Quattrini, Stefano Carlo Previtali

J Exp Med. 2014 Jan 13; 211(1): 29–43. doi: 10.1084/jem.20130720

PMCID:: PMC3892969

Abstract Article PDF–4.5M

Select item 384451610.

Murine Fig4 is dispensable for muscle development but required for muscle function

Aaron Reifler, Guy M Lenk, Xingli Li, Linda Groom, Susan V Brooks, Desmond Wilson, Michyla Bowerson, Robert T Dirksen, Miriam H Meisler, James J Dowling

Skelet Muscle. 2013; 3: 21. Published online 2013 Sep 1. doi: 10.1186/2044-5040-3-21

PMCID:: PMC3844516

Abstract Article PDF–1.9M

Select item 371146511.

Congenital CNS Hypomyelination in the Fig4 Null Mouse Is Rescued by Neuronal Expression of the PI(3,5)P₂ Phosphatase Fig4

Jesse J. Winters, Cole J. Ferguson, Guy M. Lenk, Vessela I. Giger-Mateeva, Peter Shrager, Miriam H. Meisler, Roman J. Giger

J Neurosci. 2011 Nov 30; 31(48): 17736–17751. doi: 10.1523/JNEUROSCI.1482-11.2011

PMCID:: PMC3711465

Abstract Article PDF–5.7M

Select item 364464112.

Yunis-Varón Syndrome Is Caused by Mutations in FIG4, Encoding a Phosphoinositide Phosphatase

Philippe M. Campeau, Guy M. Lenk, James T. Lu, Yangjin Bae, Lindsay Burrage, Peter Turnpenny, Jorge Román Corona-Rivera, Lucia Morandi, Marina Mora, Heiko Reutter, Anneke T. Vulto-van Silfhout, Laurence Faivre, Eric Haan, Richard A. Gibbs, Miriam H. Meisler, Brendan H. Lee

Am J Hum Genet. 2013 May 2; 92(5): 781–791. doi: 10.1016/j.ajhg.2013.03.020

PMCID:: PMC3644641

Abstract Article PDF–1.3M

Select item 349150613.

In vivo, Pikfyve generates PI(3,5)P₂, which serves as both a signaling lipid and the major precursor for PI5P

Sergey N. Zolov, Dave Bridges, Yanling Zhang, Wei-Wei Lee, Ellen Riehle, Rakesh Verma, Guy M. Lenk, Kimber Converso-Baran, Thomas Weide, Roger L. Albin, Alan R. Saltiel, Miriam H. Meisler, Mark W. Russell, Lois S. Weisman

Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43): 17472–17477. Published online 2012 Oct 9. doi: 10.1073/pnas.1203106109

PMCID:: PMC3491506

Abstract Article PDF–1.0M

Select item 341993214.

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P

Yanling Zhang, Amber J McCartney, Sergey N Zolov, Cole J Ferguson, Miriam H Meisler, Michael A Sutton, Lois S Weisman

EMBO J. 2012 Aug 15; 31(16): 3442–3456. Published online 2012 Jul 27. doi: 10.1038/emboj.2012.200

PMCID:: PMC3419932

Abstract Article PDF–2.1M

Select item 340842115.

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

Dave Bridges, Jing-Tyan Ma, Sujin Park, Ken Inoki, Lois S. Weisman, Alan R. Saltiel

Mol Biol Cell. 2012 Aug 1; 23(15): 2955–2962. doi: 10.1091/mbc.E11-12-1034

PMCID:: PMC3408421

Abstract Article PDF–4.0M

Select item 340675316.

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration

C. J. Ferguson, G. M. Lenk, J. M. Jones, A. E. Grant, J. J. Winters, J. J. Dowling, R. J. Giger, Miriam H. Meisler

Hum Mol Genet. 2012 Aug 15; 21(16): 3525–3534. Published online 2012 May 11. doi: 10.1093/hmg/dds179

PMCID:: PMC3406753

Abstract Article PDF–714K

Select item 319767917.

Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies

Ilaria Vaccari, Giorgia Dina, Hélène Tronchère, Emily Kaufman, Gaëtan Chicanne, Federica Cerri, Lawrence Wrabetz, Bernard Payrastre, Angelo Quattrini, Lois S. Weisman, Miriam H. Meisler, Alessandra Bolino

PLoS Genet. 2011 Oct; 7(10): e1002319. Published online 2011 Oct 20. doi: 10.1371/journal.pgen.1002319

PMCID:: PMC3197679

Abstract Article PDF–6.2M

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 310719719.

Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J

Guy M. Lenk, Cole J. Ferguson, Clement Y. Chow, Natsuko Jin, Julie M. Jones, Adrienne E. Grant, Sergey N. Zolov, Jesse J. Winters, Roman J. Giger, James J. Dowling, Lois S. Weisman, Miriam H. Meisler

PLoS Genet. 2011 Jun; 7(6): e1002104. Published online 2011 Jun 2. doi: 10.1371/journal.pgen.1002104

PMCID:: PMC3107197

Abstract Article PDF–2.6M

Select item 302253420.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

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