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Select item 112127311.

TGR5 deficiency in excitatory neurons ameliorates Alzheimer’s pathology by regulating APP processing

Chenli Li, Liangjie Wang, Wenting Xie, Erqu Chen, Yanbing Chen, Huifang Li, Dan Can, Aiyu Lei, Yue Wang, Jie Zhang

Sci Adv. 2024 Jun 28; 10(26): eado1855. Published online 2024 Jun 28. doi: 10.1126/sciadv.ado1855

PMCID:: PMC11212731

Abstract Article PDF–8.5M

Select item 111991462.

Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy

Hu Wang, Jiaxing Wang, Hao Cui, Chenyu Fan, Yuzhou Xue, Huiying Liu, Hui Li, Jianping Li, Houhua Li, Ying Sun, Wengong Wang, Jiangping Song, Changtao Jiang, Ming Xu

Nat Metab. 2024; 6(6): 1161–1177. Published online 2024 May 2. doi: 10.1038/s42255-024-01036-5

PMCID:: PMC11199146

Abstract Article PDF–21M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103243604.

Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain

Yuning Wu, Yuxin Qiu, Minzhi Su, Linjie Wang, Qingjuan Gong, Xuhong Wei

CNS Neurosci Ther. 2023 Jul; 29(7): 1981–1998. Published online 2023 Mar 7. doi: 10.1111/cns.14154

PMCID:: PMC10324360

Abstract Article PDF–24M

Select item 101459465.

Tgr5^−/− mice are protected from ethanol-induced metabolic alterations through enhanced leptin and Fgf21 signaling

Sabita Pokhrel, Matthew Dilts, Zachary Stahl, Shannon Boehme, Gabrielle Frame, John Y.L. Chiang, Jessica M. Ferrell

Hepatol Commun. 2023 May; 7(5): e0138. Published online 2023 Apr 26. doi: 10.1097/HC9.0000000000000138

PMCID:: PMC10145946

Abstract Article PDF–1.5M

Select item 96388046.

The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice

Xiaoxin X. Wang, Cen Xie, Andrew E. Libby, Suman Ranjit, Jonathan Levi, Komuraiah Myakala, Kanchan Bhasin, Bryce A. Jones, David J. Orlicky, Shogo Takahashi, Alexander Dvornikov, David E. Kleiner, Stephen M. Hewitt, Luciano Adorini, Jeffrey B. Kopp, Kristopher W. Krausz, Avi Rosenberg, James L. McManaman, Charles E. Robertson, Diana Ir, Daniel N. Frank, Yuhuan Luo, Frank J. Gonzalez, Enrico Gratton, Moshe Levi

J Biol Chem. 2022 Nov; 298(11): 102530. Published online 2022 Oct 7. doi: 10.1016/j.jbc.2022.102530

PMCID:: PMC9638804

Abstract Article PDF–10M

Select item 92008377.

TGR5 agonists induce peripheral and central hypersensitivity to bladder distension

Ashlee Caldwell, Luke Grundy, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Nigel W. Bunnett, Stuart M. Brierley

Sci Rep. 2022; 12: 9920. Published online 2022 Jun 15. doi: 10.1038/s41598-022-14195-w

PMCID:: PMC9200837

Abstract Article PDF–2.3M

Select item 91896618.

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Laura Thirouard, Hélène Holota, Mélusine Monrose, Manon Garcia, Angélique de Haze, Christelle Damon‐Soubeyrand, Yoan Renaud, Jean‐Paul Saru, Alessia Perino, Kristina Schoonjans, Claude Beaudoin, David H. Volle

Adv Sci (Weinh) 2022 Jun; 9(17): 2200626. Published online 2022 Apr 18. doi: 10.1002/advs.202200626

PMCID:: PMC9189661

Abstract Article PDF–6.2M

Select item 90196339.

GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer’s Disease

Jahirul Islam, Jung-Ah Cho, Ju-yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C. Kim, Kyung-Hwa Lee, Seung-Yong Seong

Front Immunol. 2022; 13: 766919. Published online 2022 Apr 6. doi: 10.3389/fimmu.2022.766919

PMCID:: PMC9019633

Abstract Article PDF–20M

Select item 858414410.

Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown

João S. Teodoro, Ivo F. Machado, Ana C. Castela, João A. Amorim, Ivana Jarak, Rui A. Carvalho, Carlos M. Palmeira, Anabela P. Rolo

Int J Mol Sci. 2021 Nov; 22(21): 11738. Published online 2021 Oct 29. doi: 10.3390/ijms222111738

PMCID:: PMC8584144

Abstract Article PDF–2.0M

Select item 794908711.

Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice

Takashi Sasaki, Yuichi Watanabe, Ayane Kuboyama, Akira Oikawa, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato

J Biol Chem. 2021 Jan-Jun; 296: 100131. Published online 2020 Dec 4. doi: 10.1074/jbc.RA120.016203

PMCID:: PMC7949087

Abstract Article PDF–1.7M

Select item 789187012.

Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects

Snehal N. Chaudhari, David A. Harris, Hassan Aliakbarian, James N. Luo, Matthew T. Henke, Renuka Subramaniam, Ashley H. Vernon, Ali Tavakkoli, Eric G. Sheu, A. Sloan Devlin

Nat Chem Biol. Author manuscript; available in PMC 2021 Feb 18.

Published in final edited form as: Nat Chem Biol. 2021 Jan; 17(1): 20–29. Published online 2020 Aug 3. doi: 10.1038/s41589-020-0604-z

PMCID:: PMC7891870

Abstract Article PDF–4.1M

Select item 766249113.

Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5

Johanna Abrigo, Fabián Campos, Francisco Gonzalez, Francisco Aguirre, Andrea Gonzalez, Camila Huerta-Salgado, Sabrina Conejeros, Felipe Simon, Marco Arrese, Daniel Cabrera, Alvaro A. Elorza, Claudio Cabello-Verrugio

Int J Mol Sci. 2020 Nov; 21(21): 7922. Published online 2020 Oct 25. doi: 10.3390/ijms21217922

PMCID:: PMC7662491

Abstract Article PDF–3.1M

Select item 761088114.

Central anorexigenic actions of bile acids are mediated by TGR5

Alessia Perino, Laura. A. Velázquez-Villegas, Nadia Bresciani, Yu Sun, Qingyao Huang, Valérie S. Fénelon, Ashley Castellanos-Jankiewicz, Philippe Zizzari, Giuseppe Bruschetta, Sungho Jin, Aiste Baleisyte, Antimo Gioiello, Roberto Pellicciari, Julijana Ivanisevic, Bernard L. Schneider, Sabrina Diano, Daniela Cota, Kristina Schoonjans

Nat Metab. Author manuscript; available in PMC 2021 Nov 24.

Published in final edited form as: Nat Metab. 2021 May 1; 3(5): 595–603. Published online 2021 May 24. doi: 10.1038/s42255-021-00398-4

PMCID:: PMC7610881

Article PDF–3.0M

Select item 740083615.

Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice

Marlena M. Holter, Margot K. Chirikjian, Daniel A. Briere, Adriano Maida, Kyle W. Sloop, Kristina Schoonjans, Bethany P. Cummings

Nutrients. 2020 Jul; 12(7): 2124. Published online 2020 Jul 17. doi: 10.3390/nu12072124

PMCID:: PMC7400836

Abstract Article PDF–2.5M

Select item 735929816.

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Elena Bellafante, Saraid McIlvride, Vanya Nikolova, Hei Man Fan, Luiza Borges Manna, Jenny Chambers, Mavis Machirori, Anita Banerjee, Kevin Murphy, Marcus Martineau, Kristina Schoonjans, Hanns-Ulrich Marschall, Peter Jones, Catherine Williamson

Sci Rep. 2020; 10: 11523. Published online 2020 Jul 13. doi: 10.1038/s41598-020-67968-6

PMCID:: PMC7359298

Abstract Article PDF–5.3M

Select item 727452517.

Microbial bile acid metabolites modulate gut RORγ⁺ regulatory T cell homeostasis

Xinyang Song, Ximei Sun, Sungwhan F. Oh, Meng Wu, Yanbo Zhang, Wen Zheng, Naama Geva-Zatorsky, Ray Jupp, Diane Mathis, Christophe Benoist, Dennis L. Kasper

Nature. Author manuscript; available in PMC 2020 Jun 5.

Published in final edited form as: Nature. 2020 Jan; 577(7790): 410–415. Published online 2019 Dec 25. doi: 10.1038/s41586-019-1865-0

PMCID:: PMC7274525

Abstract Article PDF–5.1M

Select item 722498918.

L-cell differentiation is induced by bile acids through GPBAR1 and paracrine GLP-1 and serotonin signaling

Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M Gribble, Daniel J. Drucker, Eelco J.P. de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W. Schwartz, Natalia Petersen

Diabetes. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Diabetes. 2020 Apr 1; 69(4): 614–623. Published online 2020 Feb 10. doi: 10.2337/db19-0764

PMCID:: PMC7224989

Abstract Article PDF–1.4M

Select item 720697519.

Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the β-catenin destruction complex

Jianhua Rao, Chao Yang, Shikun Yang, Hao Lu, Yuanchang Hu, Ling Lu, Feng Cheng, Xuehao Wang

Int Immunol. 2020 May; 32(5): 321–334. Published online 2020 Jan 13. doi: 10.1093/intimm/dxaa002

Correction in:: Int Immunol. 2020 Jan; 34(1): 53.

PMCID:: PMC7206975

Abstract Article PDF–12M

Select item 691267920.

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

Caroline Klindt, Maria Reich, Birte Hellwig, Jan Stindt, Jörg Rahnenführer, Jan G. Hengstler, Karl Köhrer, Kristina Schoonjans, Dieter Häussinger, Verena Keitel

Cells. 2019 Nov; 8(11): 1467. Published online 2019 Nov 19. doi: 10.3390/cells8111467

PMCID:: PMC6912679

Abstract Article PDF–4.8M

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