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Select item 109241051.

Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress

Zhe Zhang, Xiang Kai Leng, Yuan Yuan Zhai, Xiao Zhang, Zhi Wei Sun, Jun Ying Xiao, Jun Feng Lu, Kun Liu, Bo Xia, Qi Gao, Miao Jia, Cheng Qi Xu, Yi Na Jiang, Xiao Gang Zhang, Kai Shan Tao, Jiang Wei Wu

Nat Commun. 2024; 15: 1908. Published online 2024 Mar 8. doi: 10.1038/s41467-024-46135-9

PMCID:: PMC10924105

Abstract Article PDF–7.5M

Select item 108236812.

ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity

Monika Svecla, Lorenzo Da Dalt, Annalisa Moregola, Jasmine Nour, Andrea Baragetti, Patrizia Uboldi, Elena Donetti, Lorenzo Arnaboldi, Giangiacomo Beretta, Fabrizia Bonacina, Giuseppe Danilo Norata

Cardiovasc Diabetol. 2024; 23: 42. Published online 2024 Jan 28. doi: 10.1186/s12933-023-02099-6

PMCID:: PMC10823681

Abstract Article PDF–3.5M

Select item 89087913.

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco Rinaldo Oggioni, John Leong, Jan-Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, Jing-Ren Zhang

J Exp Med. 2022 Apr 4; 219(4): e20212032. Published online 2022 Mar 8. doi: 10.1084/jem.20212032

PMCID:: PMC8908791

Abstract Article PDF–8.0M

Select item 85256414.

Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression

Yingying Xu, Jiawang Tao, Xiaorui Yu, Yuhang Wu, Yan Chen, Kai You, Jiaye Zhang, Anteneh Getachew, Tingcai Pan, Yuanqi Zhuang, Fang Yuan, Fan Yang, Xianhua Lin, Yin-xiong Li

JCI Insight. 2021 Oct 8; 6(19): e147038. Published online 2021 Oct 8. doi: 10.1172/jci.insight.147038

PMCID:: PMC8525641

Abstract Article PDF–9.3M

Select item 84794805.

Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin

Delia Susan-Resiga, Emmanuelle Girard, Rachid Essalmani, Anna Roubtsova, Jadwiga Marcinkiewicz, Rabeb M. Derbali, Alexandra Evagelidis, Jae H. Byun, Paul F. Lebeau, Richard C. Austin, Nabil G. Seidah

J Biol Chem. 2021 Oct; 297(4): 101177. Published online 2021 Sep 8. doi: 10.1016/j.jbc.2021.101177

PMCID:: PMC8479480

Abstract Article PDF–4.1M

Select item 84205056.

Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites

David Hoffmann, Stefan Mereiter, Yoo Jin Oh, Vanessa Monteil, Elizabeth Elder, Rong Zhu, Daniel Canena, Lisa Hain, Elisabeth Laurent, Clemens Grünwald‐Gruber, Miriam Klausberger, Gustav Jonsson, Max J Kellner, Maria Novatchkova, Melita Ticevic, Antoine Chabloz, Gerald Wirnsberger, Astrid Hagelkruys, Friedrich Altmann, Lukas Mach, Johannes Stadlmann, Chris Oostenbrink, Ali Mirazimi, Peter Hinterdorfer, Josef M Penninger

EMBO J. 2021 Oct 1; 40(19): e108375. Published online 2021 Aug 23. doi: 10.15252/embj.2021108375

PMCID:: PMC8420505

Abstract Article PDF–5.3M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 70030668.

Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation

Panagiota Karagianni, Panagiotis Moulos, Dominic Schmidt, Duncan T. Odom, Iannis Talianidis

Cell Rep. 2020 Feb 4; 30(5): 1319–1328.e6. Published online 2019 Feb 4. doi: 10.1016/j.celrep.2020.01.006

PMCID:: PMC7003066

Abstract Article

Select item 62236619.

Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis

Won Ho Yang, Douglas M. Heithoff, Peter V. Aziz, Benjamin Haslund-Gourley, Julia S. Westman, Sonoko Narisawa, Anthony B. Pinkerton, José Luis Millán, Victor Nizet, Michael J. Mahan, Jamey D. Marth

Cell Host Microbe. Author manuscript; available in PMC 2019 Oct 10.

Published in final edited form as: Cell Host Microbe. 2018 Oct 10; 24(4): 500–513.e5. doi: 10.1016/j.chom.2018.09.011

PMCID:: PMC6223661

Article PDF–1.8M

Select item 538964310.

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Karsten Schmidt, Thazha P. Prakash, Aaron J. Donner, Garth A. Kinberger, Hans J. Gaus, Audrey Low, Michael E. Østergaard, Melanie Bell, Eric E. Swayze, Punit P. Seth

Nucleic Acids Res. 2017 Mar 17; 45(5): 2294–2306. Published online 2017 Feb 3. doi: 10.1093/nar/gkx060

PMCID:: PMC5389643

Abstract Article PDF–897K

Select item 500924611.

Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation

Yiling Mi, Marcy Coonce, Dorothy Fiete, Lindsay Steirer, Gabriela Dveksler, R. Reid Townsend, Jacques U. Baenziger

J Biol Chem. 2016 Sep 2; 291(36): 18700–18717. Published online 2016 Jul 12. doi: 10.1074/jbc.M116.738948

PMCID:: PMC5009246

Abstract Article PDF–3.1M

Select item 464073712.

An intrinsic mechanism of secreted protein aging and turnover

Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Michael J. Mahan, Jeffrey W. Smith, Jamey D. Marth

Proc Natl Acad Sci U S A. 2015 Nov 3; 112(44): 13657–13662. Published online 2015 Oct 21. doi: 10.1073/pnas.1515464112

PMCID:: PMC4640737

Abstract Article PDF–1.7M

Select item 442815213.

Dual roles for hepatic lectin receptors in the clearance of chilled platelets

Viktoria Rumjantseva, Prabhjit K. Grewal, Hans H. Wandall, Emma C. Josefsson, Anne Louise Sørensen, Göran Larson, Jamey D. Marth, John H. Hartwig, Karin M. Hoffmeister

Nat Med. Author manuscript; available in PMC 2015 May 12.

Published in final edited form as: Nat Med. 2009 Nov; 15(11): 1273–1280. Published online 2009 Sep 27. doi: 10.1038/nm.2030

PMCID:: PMC4428152

Abstract Article PDF–994K

Select item 357241014.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 340130515.

New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis

Sibylle Sabrautzki, Isabel Rubio-Aliaga, Wolfgang Hans, Helmut Fuchs, Birgit Rathkolb, Julia Calzada-Wack, Christian M. Cohrs, Matthias Klaften, Hartwig Seedorf, Sebastian Eck, Ana Benet-Pagès, Jack Favor, Irene Esposito, Tim M. Strom, Eckhard Wolf, Bettina Lorenz-Depiereux, Martin Hrabě de Angelis

Mamm Genome. 2012; 23(7): 416–430. Published online 2012 Apr 21. doi: 10.1007/s00335-012-9397-z