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Select item 106276891.

Expression and clinical association of MFG-E8 and TAM receptors in diabetic patients with different stages of microvascular complication: An experimental study

Yin Xiong, Beibei Wang, Jinyu Jiao, Meina Tang, Ke Li, Rui Jiang, Wei Huang

Medicine (Baltimore) 2023 Nov 3; 102(44): e35788. Published online 2023 Nov 3. doi: 10.1097/MD.0000000000035788

PMCID:: PMC10627689

Abstract Article PDF–1.1M

Select item 101883552.

TYRO3 promotes tumorigenesis and drug resistance in colorectal cancer by enhancing the epithelial-mesenchymal transition process

Xinyu Shao, Yibin Sun, Kaiqiang Zhong, Jinrong Gu, Yang Yu, Tong Hu, Xiaoyi Kuai, Yechen Xing

Aging (Albany NY) 2023 Apr 30; 15(8): 3035–3051. Published online 2023 Apr 14. doi: 10.18632/aging.204656

PMCID:: PMC10188355

Abstract Article PDF–1.4M

Select item 100965873.

Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

Pei-Ling Hsu, Chun-Wei Chien, Yen-An Tang, Bo-Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H. Sunny Sun, Shaw-Jenq Tsai

Sci Adv. 2023 Apr; 9(15): eade3422. Published online 2023 Apr 12. doi: 10.1126/sciadv.ade3422

Correction in:: Sci Adv. 2023 Nov 10; 9(45): eadl3229.

PMCID:: PMC10096587

Abstract Article PDF–3.0M

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98700755.

TYRO3 agonist as therapy for glomerular disease

Fang Zhong, Hong Cai, Jia Fu, Zeguo Sun, Zhengzhe Li, David Bauman, Lois Wang, Bhaskar Das, Kyung Lee, John Cijiang He

JCI Insight. 2023 Jan 10; 8(1): e165207. Published online 2023 Jan 10. doi: 10.1172/jci.insight.165207

PMCID:: PMC9870075

Abstract Article PDF–13M

Select item 91714116.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 91063037.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 83630698.

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-dependent Chemoresistance and PD-L1 Expression

Canan Kasikara, Sushil Kumar, Stanley Kimani, Wen-I Tsou, Ke Geng, Viralkumar Davra, Ganapathy Sriram, Connor Devoe, Khanh-Quynh N. Nguyen, Anita Antes, Allen Krantz, Grzegorz Rymarczyk, Andrzej Wilczynski, Cyril Empig, Bruce Freimark, Michael Gray, Kyle Schlunegger, Jeff Hutchins, Sergei V. Kotenko, Raymond B. Birge

Mol Cancer Res. Author manuscript; available in PMC 2021 Aug 13.

Published in final edited form as: Mol Cancer Res. 2017 Jun; 15(6): 753–764. Published online 2017 Feb 9. doi: 10.1158/1541-7786.MCR-16-0350

PMCID:: PMC8363069

Abstract Article PDF–2.4M

Select item 82625019.

TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis

Zhou Jiang, Seung-Oe Lim, Meisi Yan, Jennifer L. Hsu, Jun Yao, Yongkun Wei, Shih-Shin Chang, Hirohito Yamaguchi, Heng-Huan Lee, Baozhen Ke, Jung-Mao Hsu, Li-Chuan Chan, Gabriel N. Hortobagyi, Liuqing Yang, Chunru Lin, Dihua Yu, Mien-Chie Hung

J Clin Invest. 2021 Apr 15; 131(8): e139434. Published online 2021 Apr 15. doi: 10.1172/JCI139434

PMCID:: PMC8262501

Abstract Article PDF–5.5M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 797118511.

TAM receptors and their ligand-mediated activation: Role in atherosclerosis

Bishuang Cai, Canan Kasikara

Int Rev Cell Mol Biol. Author manuscript; available in PMC 2021 Mar 18.

Published in final edited form as: Int Rev Cell Mol Biol. 2020; 357: 21–33. Published online 2020 Oct 5. doi: 10.1016/bs.ircmb.2020.09.001

PMCID:: PMC7971185

Abstract Article PDF–633K

Select item 783483512.

Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target

Pier Paolo Sainaghi, Mattia Bellan, Alessandra Nerviani

Dis Markers. 2021; 2021: 2854925. Published online 2021 Jan 13. doi: 10.1155/2021/2854925

PMCID:: PMC7834835

Article PDF–318K

Select item 750213613.

Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis

Julia Vullings, Juliana P. Vago, Claire E. J. Waterborg, Rogier M. Thurlings, Marije I. Koenders, Peter L. E. M. van Lent, Peter M. van der Kraan, Flavio A. Amaral, Fons A. J. van de Loo

J Immunol Res. 2020; 2020: 9690832. Published online 2020 Sep 11. doi: 10.1155/2020/9690832

PMCID:: PMC7502136

Abstract Article PDF–1.8M

Select item 742732714.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 740797315.

Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells

Nour Al Kafri, Sassan Hafizi

Biomolecules. 2020 Jul; 10(7): 1035. Published online 2020 Jul 11. doi: 10.3390/biom10071035

PMCID:: PMC7407973

Abstract Article PDF–3.6M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 704178617.

TYRO3 facilitates cell growth and metastasis via activation of the Wnt/β-catenin signaling pathway in human gastric cancer cells

Dehu Chen, Qinghong Liu, Gan Cao, Wei Zhang

Aging (Albany NY) 2020 Feb 15; 12(3): 2261–2274. Published online 2020 Feb 4. doi: 10.18632/aging.102744

PMCID:: PMC7041786

Abstract Article PDF–1.3M

Select item 699548718.

New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis

Sara Pagani, Mattia Bellan, Daniele Mauro, Luigi Mario Castello, Gian Carlo Avanzi, Myles J. Lewis, Pier Paolo Sainaghi, Costantino Pitzalis, Alessandra Nerviani

Dis Markers. 2020; 2020: 1614627. Published online 2020 Jan 19. doi: 10.1155/2020/1614627

PMCID:: PMC6995487

Abstract Article PDF–583K

Select item 694398319.

TAM Family Receptor kinase inhibition reverses MDSC-mediated suppression and augments anti-PD-1 therapy in melanoma.

Alisha Holtzhausen, William Harris, Eric Ubil, Debra M. Hunter, Jichen Zhao, Yuewei Zhang, Dehui Zhang, Qingyang Liu, Xiaodong Wang, Douglas K. Graham, Stephen V. Frye, H. Shelton Earp

Cancer Immunol Res. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: Cancer Immunol Res. 2019 Oct; 7(10): 1672–1686. Published online 2019 Aug 26. doi: 10.1158/2326-6066.CIR-19-0008

PMCID:: PMC6943983

Abstract Article PDF–2.0M

Select item 674264620.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

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