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Select item 100947211.

Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX

Miquel Canyelles-Niño, Àngels González-Lafont, José M. Lluch

Int J Mol Sci. 2023 Apr; 24(7): 6064. Published online 2023 Mar 23. doi: 10.3390/ijms24076064

PMCID:: PMC10094721

Abstract Article PDF–20M

Select item 98884332.

Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder

Michelle Tran, Rachel L. Signorelli, Adriana Yamaguchi, Eefie Chen, Michael Holinstat, Anthony T. Iavarone, Adam R. Offenbacher, Theodore Holman

Arch Biochem Biophys. Author manuscript; available in PMC 2023 Jan 31.

Published in final edited form as: Arch Biochem Biophys. 2023 Jan 1; 733: 109472. Published online 2022 Nov 25. doi: 10.1016/j.abb.2022.109472

PMCID:: PMC9888433

Abstract Article PDF–1.3M

Select item 92718593.

ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal Cancer

Siyuan Weng, Zaoqu Liu, Hui Xu, Xiaoyong Ge, Yuqing Ren, Qin Dang, Long Liu, Jian Zhang, Peng Luo, Jianzhuang Ren, Xinwei Han

Front Immunol. 2022; 13: 910582. Published online 2022 Jun 27. doi: 10.3389/fimmu.2022.910582

PMCID:: PMC9271859

Abstract Article PDF–26M

Select item 87489584.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 84560515.

Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase

Annalisa Contursi, Simone Schiavone, Melania Dovizio, Christine Hinz, Rosa Fullone, Stefania Tacconelli, Victoria J. Tyrrell, Rosalia Grande, Paola Lanuti, Marco Marchisio, Mirco Zucchelli, Patrizia Ballerini, Angel Lanas, Valerie B. O'Donnell, Paola Patrignani

J Lipid Res. 2021; 62: 100109. Published online 2021 Aug 21. doi: 10.1016/j.jlr.2021.100109

PMCID:: PMC8456051

Abstract Article PDF–3.1M

Select item 81503726.

Regulation of Tissue Inflammation by 12-Lipoxygenases

Abhishek Kulkarni, Jerry L. Nadler, Raghavendra G. Mirmira, Isabel Casimiro

Biomolecules. 2021 May; 11(5): 717. Published online 2021 May 11. doi: 10.3390/biom11050717

PMCID:: PMC8150372

Abstract Article PDF–1.9M

Select item 77292817.

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators

Cody Freedman, Adrianne Tran, Benjamin E. Tourdot, Chakrapani Kalyanaraman, Steve Perry, Michael Holinstat, Matthew P. Jacobson, Theodore R. Holman

Biochemistry. Author manuscript; available in PMC 2021 May 19.

Published in final edited form as: Biochemistry. 2020 May 19; 59(19): 1832–1844. Published online 2020 May 7. doi: 10.1021/acs.biochem.0c00233

PMCID:: PMC7729281

Abstract Article PDF–829K

Select item 75668818.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 72701479.

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-type 12-Lipoxygenase

Ansari Mukhtar Aleem, Wan-Chen Tsai, Jennyfer Tena, Gabriella Alvarez, Joshua Deschamps, Chakrapani Kalyanaraman, Matthew P. Jacobson, Theodore Holman

Biochemistry. Author manuscript; available in PMC 2020 Jun 4.

Published in final edited form as: Biochemistry. 2019 Feb 12; 58(6): 848–857. Published online 2019 Jan 4. doi: 10.1021/acs.biochem.8b01167

PMCID:: PMC7270147

Abstract Article PDF–649K

Select item 727014210.

5S,15S-Dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1

Abigail R. Green, Cody Freedman, Jennyfer Tena, Benjamin E. Tourdot, Benjamin Liu, Michael Holinstat, Theodore R. Holman

Biochemistry. Author manuscript; available in PMC 2020 Jun 4.

Published in final edited form as: Biochemistry. 2018 Dec 4; 57(48): 6726–6734. Published online 2018 Nov 15. doi: 10.1021/acs.biochem.8b00889

PMCID:: PMC7270142

Abstract Article PDF–761K

Select item 724269211.

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer

Ehab H. Sarsour, Jyung Mean Son, Amanda L. Kalen, Wusheng Xiao, Juan Du, Matthew S. Alexander, Brianne R. O'Leary, Joseph J. Cullen, Prabhat C. Goswami

J Biol Chem. 2020 May 15; 295(20): 6946–6957. Published online 2020 Apr 7. doi: 10.1074/jbc.RA120.012798

PMCID:: PMC7242692

Abstract Article PDF–2.9M

Select item 724249212.

The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma

Lily Oguh-Olayinka, Vijay Agarwal, Dulani Ranatunge, Anne Campbell, Stefan Laufer, Lynn Cawkwell, Michael J. Lind

Pathol Oncol Res. 2020; 26(2): 985–995. Published online 2019 Apr 2. doi: 10.1007/s12253-019-00652-x

PMCID:: PMC7242492

Abstract Article PDF–1.7M

Select item 721856013.

Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis

Jee Yeon Kim, Bong-Geun Choi, Jaroslav Jelinek, Dae Hyun Kim, Seo Hyun Lee, Kwangjo Cho, Seo Hee Rha, Young Ho Lee, Hyo Sun Jin, Dae-Kyoung Choi, Geun-Eun Kim, Sun U. Kwon, Junha Hwang, Jae Kwan Cha, Sukhoon Lee, Jean-Pierre J. Issa, Jei Kim

Clin Epigenetics. 2020; 12: 66. Published online 2020 May 12. doi: 10.1186/s13148-020-00846-0

PMCID:: PMC7218560

Abstract Article PDF–2.1M

Select item 720157214.

The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer

Qi Zhang, Guifang Yan, Juan Lei, Yu Chen, Ting Wang, Juan Gong, Yong Zhou, Huakan Zhao, Hao Chen, Yu Zhou, Lei Wu, Jiangang Zhang, Xiao Zhang, Jingchun Wang, Yongsheng Li

Mol Med. 2020; 26: 39. Published online 2020 May 6. doi: 10.1186/s10020-020-00174-2

PMCID:: PMC7201572

Abstract Article PDF–1.7M

Select item 717052215.

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA₂γ knockout

Xinping Liu, Harold F. Sims, Christopher M. Jenkins, Shaoping Guan, Beverly G. Dilthey, Richard W. Gross

J Biol Chem. 2020 Apr 17; 295(16): 5307–5320. Published online 2020 Mar 11. doi: 10.1074/jbc.RA119.012296

PMCID:: PMC7170522

Abstract Article PDF–3.1M

Select item 677488816.

12-lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat

Luiz Osório Leiria, Chih-Hao Wang, Matthew D. Lynes, Kunyan Yang, Farnaz Shamsi, Mari Sato, Satoru Sugimoto, Emily Y. Chen, Valerie Bussberg, Niven R. Narain, Brian E. Sansbury, Justin Darcy, Tian Lian Huang, Sean D. Kodani, Masaji Sakaguchi, Andréa L. Rocha, Tim J. Schulz, Alexander Bartelt, Gökhan S. Hotamisligil, Michael F. Hirshman, Klaus van Leyen, Laurie J. Goodyear, Matthias Blüher, Aaron M. Cypess, Michael A. Kiebish, Matthew Spite, Yu-Hua Tseng

Cell Metab. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Cell Metab. 2019 Oct 1; 30(4): 768–783.e7. Published online 2019 Jul 25. doi: 10.1016/j.cmet.2019.07.001

PMCID:: PMC6774888

Abstract Article PDF–3.0M

Select item 662484017.

ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway

Bo Chu, Ning Kon, Delin Chen, Tongyuan Li, Tong Liu, Le Jiang, Shujuan Song, Omid Tavana, Wei Gu

Nat Cell Biol. Author manuscript; available in PMC 2019 Oct 8.

Published in final edited form as: Nat Cell Biol. 2019 May; 21(5): 579–591. Published online 2019 Apr 8. doi: 10.1038/s41556-019-0305-6

PMCID:: PMC6624840

Abstract Article PDF–2.1M

Select item 633851818.

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

Nikhlesh K. Singh, Gadiparthi N. Rao

Prog Lipid Res. Author manuscript; available in PMC 2020 Jan 1.

Published in final edited form as: Prog Lipid Res. 2019 Jan; 73: 28–45. Published online 2018 Nov 22. doi: 10.1016/j.plipres.2018.11.001

PMCID:: PMC6338518

Abstract Article PDF–1.1M

Select item 564324019.

Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase

Niharika Samala, Sarah A. Tersey, Naga Chalasani, Ryan M. Anderson, Raghavendra G. Mirmira

J Diabetes Complications. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: J Diabetes Complications. 2017 Nov; 31(11): 1630–1637. Published online 2017 Jul 31. doi: 10.1016/j.jdiacomp.2017.07.014

PMCID:: PMC5643240

Abstract Article PDF–501K

Select item 548869320.

12-HETrE, a 12-LOX oxylipin of DGLA, inhibits thrombosis via Gα_s signaling in platelets

Jennifer Yeung, Benjamin E. Tourdot, Reheman Adili, Abigail R. Green, Cody J. Freedman, Pilar Fernandez-Perez, Johnny Yu, Theodore R. Holman, Michael Holinstat

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Oct; 36(10): 2068–2077. Published online 2016 Jul 28. doi: 10.1161/ATVBAHA.116.308050

PMCID:: PMC5488693

Abstract Article PDF–1.0M

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