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Select item 114318821.

Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9 bglap–bglap2 Deficiency Mouse Model

Xiang-Fang Yu, Bin Teng, Jun-Feng Li, Jian V. Zhang, Zhe Su, Pei-Gen Ren

Int J Mol Sci. 2024 Sep; 25(18): 9945. Published online 2024 Sep 15. doi: 10.3390/ijms25189945

PMCID:: PMC11431882

Abstract Article PDF–3.4M

Select item 108972162.

Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring

Danilo Correa Pinto Junior, Isabella Canal Delgado, Haiyang Yang, Alisson Clemenceau, André Corvelo, Giuseppe Narzisi, Rajeeva Musunuri, Julian Meyer Berger, Lauren E Hendricks, Kazuya Tokumura, Na Luo, Hongchao Li, Franck Oury, Patricia Ducy, Vijay K Yadav, Xiang Li, Gerard Karsenty

EMBO Rep. 2024 Feb; 25(2): 593–615. Published online 2024 Jan 16. doi: 10.1038/s44319-023-00031-3

PMCID:: PMC10897216

Abstract Article PDF–6.0M

Select item 107904173.

Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity

Angela Ruscitto, Peng Chen, Ikue Tosa, Ziyi Wang, Gan Zhou, Ingrid Safina, Ran Wei, Mallory M Morel, Alia Koch, Michael Forman, Gwendolyn Reeve, Michael K Lecholop, Marshall Wilson, Daniel Bonthius, Mo Chen, Mitsuaki Ono, Timothy C Wang, Hai Yao, Mildred C Embree

Cell Stem Cell. Author manuscript; available in PMC 2024 Sep 7.

Published in final edited form as: Cell Stem Cell. 2023 Sep 7; 30(9): 1179–1198.e7. doi: 10.1016/j.stem.2023.08.004

PMCID:: PMC10790417

Abstract Article PDF–6.0M

Select item 106562854.

Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype

Vijesh G. Vaghjiani, Catherine R. Cochrane, W. Samantha N. Jayasekara, Wai Chin Chong, Anette Szczepny, Beena Kumar, Luciano G. Martelotto, Andrew McCaw, Kirstyn Carey, Maya Kansara, David M. Thomas, Carl Walkley, Stuart Mudge, Daniel J. Gough, Peter A. Downie, Craig D. Peacock, William Matsui, D. Neil Watkins, Jason E. Cain

Oncogene. 2023; 42(47): 3529–3541. Published online 2023 Oct 16. doi: 10.1038/s41388-023-02864-7

PMCID:: PMC10656285

Abstract Article PDF–4.5M

Select item 106519545.

Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD‐induced menopausal mice

Yiting Kang, Jie Yao, Xiaohang Gao, Hao Zhong, Yifei Song, Xiaohui Di, Zeguo Feng, Lin Xie, Jianbao Zhang

CNS Neurosci Ther. 2023 Dec; 29(12): 3980–3994. Published online 2023 Jul 4. doi: 10.1111/cns.14324

PMCID:: PMC10651954

Abstract Article PDF–53M

Select item 106453996.

Insulin-Like Growth Factor-I Is Essential for Embryonic Bone Development

Yongmei Wang, Shigeki Nishida, Takeshi Sakata, Hashem Z. Elalieh, Wenhan Chang, Bernard P. Halloran, Steven B. Doty, Daniel D. Bikle

Endocrinology. Author manuscript; available in PMC 2023 Nov 14.

Published in final edited form as: Endocrinology. 2006 Oct; 147(10): 4753–4761. Published online 2006 Jul 20. doi: 10.1210/en.2006-0196

PMCID:: PMC10645399

Abstract Article PDF–2.8M

Select item 103242787.

USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice

Xingguo Li, Jun Zhang, Bing Wang, Chao Chen, Enyu Zhang, Zhengpin Lv, Qicong He, Yaoquan Hu, Xuenan Wang, Fan Zhang

Biol Direct. 2023; 18: 37. Published online 2023 Jul 6. doi: 10.1186/s13062-023-00395-5

PMCID:: PMC10324278

Abstract Article PDF–2.7M

Select item 102566858.

Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate

Mahdia Taieb, Dima Ghannoum, Lydia Barré, Mohamed Ouzzine

Cell Death Dis. 2023 Jun; 14(6): 355. Published online 2023 Jun 9. doi: 10.1038/s41419-023-05875-0

PMCID:: PMC10256685

Abstract Article PDF–8.3M

Select item 100893039.

Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice

Zihan Xu, Chao Yang, Feng Wu, Xiaowen Tan, Yaxiu Guo, Hongyu Zhang, Hailong Wang, Xiukun Sui, Zi Xu, Minbo Zhao, Siyu Jiang, Zhongquan Dai, Yinghui Li

Front Physiol. 2023; 14: 1136561. Published online 2023 Mar 28. doi: 10.3389/fphys.2023.1136561

PMCID:: PMC10089303

Abstract Article PDF–3.6M

Select item 994624810.

Ectomesenchymal Six1 controls mandibular skeleton formation

Songyuan Luo, Zhixu Liu, Qian Bian, Xudong Wang

Front Genet. 2023; 14: 1082911. Published online 2023 Feb 8. doi: 10.3389/fgene.2023.1082911

PMCID:: PMC9946248

Abstract Article PDF–4.5M

Select item 989855211.

Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis

Runze Jin, Hanshu Zhang, Chujiao Lin, Jinqiang Guo, Weiguo Zou, Zhi Chen, Huan Liu

Exp Mol Med. 2023 Jan; 55(1): 69–80. Published online 2023 Jan 4. doi: 10.1038/s12276-022-00914-w

PMCID:: PMC9898552

Abstract Article PDF–9.9M

Select item 971088112.

GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis

Takamitsu Maruyama, Daigaku Hasegawa, Tomas Valenta, Jody Haigh, Maxime Bouchard, Konrad Basler, Wei Hsu

Sci Adv. 2022 Dec; 8(48): eadd6172. Published online 2022 Nov 30. doi: 10.1126/sciadv.add6172

PMCID:: PMC9710881

Abstract Article PDF–2.2M

Select item 967555613.

DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities

M. Elena Martinez, Ilka Pinz, Marilena Preda, Christine R. Norton, Thomas Gridley, Arturo Hernandez

JCI Insight. 2022 Nov 8; 7(21): e161214. Published online 2022 Nov 8. doi: 10.1172/jci.insight.161214

PMCID:: PMC9675556

Abstract Article PDF–3.9M

Select item 884375314.

Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse

Vijay K. Yadav, Julian M. Berger, Parminder Singh, Perumal Nagarajan, Gerard Karsenty

J Clin Invest. 2022 Feb 15; 132(4): e153752. Published online 2022 Feb 15. doi: 10.1172/JCI153752

PMCID:: PMC8843753

Abstract Article PDF–4.9M

Select item 882887415.

The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development

Fatma F. Mohamed, Chunxi Ge, Randy T. Cowling, Daniel Lucas, Shawn A. Hallett, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Renny T. Franceschi

Bone Res. 2022; 10: 11. Published online 2022 Feb 9. doi: 10.1038/s41413-021-00182-w

PMCID:: PMC8828874

Abstract Article PDF–6.8M

Select item 874296216.

Osteogenic and angiogenic profiles of the palatal process of the maxilla and the palatal process of the palatine bone

Caiyu Liao, Meng Lu, Yuhang Hong, Chuanqing Mao, Jiangping Chen, Chengyan Ren, Minkui Lin, Weihui Chen

J Anat. 2022 Feb; 240(2): 385–397. Published online 2021 Sep 26. doi: 10.1111/joa.13545

PMCID:: PMC8742962

Abstract Article PDF–2.1M

Select item 866494517.

Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta

Yang Chen, Sujuan Yang, Sara Lovisa, Catherine G. Ambrose, Kathleen M. McAndrews, Hikaru Sugimoto, Raghu Kalluri

Nat Commun. 2021; 12: 7199. Published online 2021 Dec 10. doi: 10.1038/s41467-021-27563-3

PMCID:: PMC8664945

Abstract Article PDF–8.8M

Select item 842139218.

Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin

Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Cristian Coarfa, Kimal Rajapakshe, Dimuthu Perera, Jizhong Cheng, Huaizhu Wu, Christie M. Ballantyne, Zheng Sun, Liang Xie, Xinchun Pi

Nat Commun. 2021; 12: 5296. Published online 2021 Sep 6. doi: 10.1038/s41467-021-25673-6

PMCID:: PMC8421392

Abstract Article PDF–1.7M

Select item 824373019.

Osteocalcin Affects Bone Mineral and Mechanical Properties in Female Mice.

O. Berezovska, G. Yildirim, W. Budell, S. Yagerman, B. Pidhaynyy, C. Bastien, M.C.H. van der Meulen, T.L. Dowd

Bone. Author manuscript; available in PMC 2021 Jun 30.

Published in final edited form as: Bone. 2019 Nov; 128: 115031. Published online 2019 Aug 8. doi: 10.1016/j.bone.2019.08.004

PMCID:: PMC8243730

Article PDF–1016K

Select item 802426120.

Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling

Long Guo, Aritoshi Iida, Gandham SriLakshmi Bhavani, Kalpana Gowrishankar, Zheng Wang, Jing-yi Xue, Juan Wang, Noriko Miyake, Naomichi Matsumoto, Takanori Hasegawa, Yusuke Iizuka, Masashi Matsuda, Tomoki Nakashima, Masaki Takechi, Sachiko Iseki, Shinsei Yambe, Gen Nishimura, Haruhiko Koseki, Chisa Shukunami, Katta M. Girisha, Shiro Ikegawa

Nat Commun. 2021; 12: 2046. Published online 2021 Apr 6. doi: 10.1038/s41467-021-22340-8