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Select item 111057701.

Bardet–Biedl Syndrome proteins regulate cilia disassembly during tissue maturation

Sarita Rani Patnaik, Viola Kretschmer, Lena Brücker, Sandra Schneider, Ann-Kathrin Volz, Liliana del Rocio Oancea-Castillo, Helen Louise May-Simera

Cell Mol Life Sci. 2019 Feb; 76(4): 757–775. Published online 2018 Nov 16. doi: 10.1007/s00018-018-2966-x

PMCID:: PMC11105770

Abstract Article PDF–3.0M

Select item 110731232.

Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage

Miao Wang, Chao Zhou, Lu Yu, Delian Kong, Weijing Ma, Bingchen Lv, Yan Wang, Weifeng Wu, Mingyue Zhou, Guiyun Cui

Cell Mol Life Sci. 2022 Jul; 79(7): 356. Published online 2022 Jun 9. doi: 10.1007/s00018-022-04341-y

PMCID:: PMC11073123

Abstract Article PDF–3.2M

Select item 110248603.

HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy

Tuo Zhang, Yuntong Tong, Rengguang Zhu, Yaoyun Liang, Jixian Zhang, Chujiao Hu, Meina He, Zhu Hu, Zhiyi Shen, Jin Niu, Jingjing Zhang, Yuanyuan Yu, Bangming Jin, Shan Lei, Zhirui Zeng, Yingmin Wu, Zengmei Cheng, Ziwen Xiao, Bing Guo, Shuyun Zhao, Guoqiang Xu, Wei Pan, Tengxiang Chen

Theranostics. 2024; 14(6): 2345–2366. Published online 2024 Mar 25. doi: 10.7150/thno.95164

PMCID:: PMC11024860

Abstract Article PDF–13M

Select item 109366004.

The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia

Minjia Chen, Xiuqin Cao, Ronghui Zheng, Haixia Chen, Ruixia He, Hao Zhou, Zhiwei Yang

Virulence. 2024; 15(1): 2327096. Published online 2024 Mar 11. doi: 10.1080/21505594.2024.2327096

PMCID:: PMC10936600

Abstract Article PDF–7.6M

Select item 108971565.

Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice

Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Ana Budan, Emma Xu, Reva Shenwai, Matthew Kozubov, Cindy Li, Melissa Van Pell, Francis Grafton, Charles E MacKay, Xiaomei Song, James R Priest, Gretchen Argast, Mohammad A. Mandegar, Timothy Hoey, Jin Yang

Nat Commun. 2024; 15: 1352. Published online 2024 Feb 26. doi: 10.1038/s41467-024-45440-7

Correction in:: Nat Commun. 2024; 15: 8749.

PMCID:: PMC10897156

Abstract Article PDF–2.0M

Select item 108800356.

Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge

Paulina M. Getsy, Gregory A. Coffee, Thomas J. Kelley, Stephen J. Lewis

Front Physiol. 2023; 14: 1332810. Published online 2024 Feb 6. doi: 10.3389/fphys.2023.1332810

PMCID:: PMC10880035

Abstract Article PDF–3.3M

Select item 108509547.

HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent

Longlong Wang, Shihua Shi, Adeline Unterreiner, Ronan Kapetanovic, Sucheta Ghosh, Jacint Sanchez, Selma Aslani, Yuan Xiong, Chi-Lin Hsu, Katherine A. Donovan, Christopher J. Farady, Eric S. Fischer, Frédéric Bornancin, Patrick Matthias

J Biol Chem. 2024 Feb; 300(2): 105638. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105638

PMCID:: PMC10850954

Abstract Article PDF–1.9M

Select item 103323018.

Histone deacetylase 6 inhibition exploits selective metabolic vulnerabilities in LKB1 mutant, KRAS driven non-small cell lung cancer

Hua Zhang, Christopher S. Nabel, Dezhi Li, Ruth Í. O’Connor, Caroline R. Crosby, Sarah M. Chang, Yuan Hao, Robyn Stanley, Soumyadip Sahu, Daniel S. Levin, Ting Chen, Sittinon Tang, Hsin-Yi Huang, Mary Meynardie, Janaye Stephens, Fiona Sherman, Alison Chafitz, Naoise Costelloe, Daniel A. Rodrigues, Hilda Fogarty, Miranda G. Kiernan, Fiona Cronin, Eleni Papadopoulos, Magdalena Ploszaj, Vajira Weerasekara, Jiehui Deng, Patrick Kiely, Nabeel Bardeesy, Matthew G. Vander Heiden, Triona Ni Chonghaile, Catríona M. Dowling, Kwok-Kin Wong

J Thorac Oncol. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: J Thorac Oncol. 2023 Jul; 18(7): 882–895. Published online 2023 Mar 22. doi: 10.1016/j.jtho.2023.03.014

PMCID:: PMC10332301

Abstract Article PDF–1.5M

Select item 102986899.

HDAC6 Deficiency Has Moderate Effects on Behaviors and Parkinson’s Disease Pathology in Mice

Jiayin Zhao, Yongtao He, Yufei Duan, Yuanyuan Ma, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Mei Yu, Fang Huang

Int J Mol Sci. 2023 Jun; 24(12): 9975. Published online 2023 Jun 9. doi: 10.3390/ijms24129975

PMCID:: PMC10298689

Abstract Article PDF–5.5M

Select item 981161910.

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6

Kohei Tsujimoto, Tatsunori Jo, Daiki Nagira, Hachiro Konaka, Jeong Hoon Park, Shin‐ichiro Yoshimura, Akinori Ninomiya, Fuminori Sugihara, Takehiro Hirayama, Eri Itotagawa, Yusei Matsuzaki, Yuki Takaichi, Wataru Aoki, Shotaro Saita, Shuhei Nakamura, Andrea Ballabio, Shigeyuki Nada, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

EMBO J. 2023 Jan; 42(1): e111389. Published online 2022 Nov 29. doi: 10.15252/embj.2022111389

PMCID:: PMC9811619

Abstract Article PDF–4.2M

Select item 980057811.

Histone deacetylase 6 plays an important role in TGF-β-induced murine Treg cell differentiation by regulating cell proliferation

Ji Hyeon Lee, Hyeong Su Kim, Sung Woong Jang, Gap Ryol Lee

Sci Rep. 2022; 12: 22550. Published online 2022 Dec 29. doi: 10.1038/s41598-022-27230-7

PMCID:: PMC9800578

Abstract Article PDF–3.4M

Select item 952523612.

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

René Winkler, Ann-Sophie Mägdefrau, Eva-Maria Piskor, Markus Kleemann, Mandy Beyer, Kevin Linke, Lisa Hansen, Anna-Maria Schaffer, Marina E. Hoffmann, Simon Poepsel, Florian Heyd, Petra Beli, Tarik Möröy, Siavosh Mahboobi, Oliver H. Krämer, Christian Kosan

Oncogene. 2022; 41(40): 4560–4572. Published online 2022 Sep 6. doi: 10.1038/s41388-022-02450-3

PMCID:: PMC9525236

Abstract Article PDF–2.6M

Select item 928788813.

H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes

Amit Kumar, Malabika Datta

Mol Med. 2022; 28: 81. Published online 2022 Jul 16. doi: 10.1186/s10020-022-00507-3

PMCID:: PMC9287888

Abstract Article PDF–2.9M

Select item 927726714.

Opposing roles of HDAC6 in liver regeneration and hepatocarcinogenesis

Sophors Phorl, Azra Memon, Yuri Seo, Thi Oanh Hoang, Trung Nghia Tran, Le Minh Tri Nguyen, Chang Hoon Lee, Woon Kyu Lee, Joo‐Yong Lee

Cancer Sci. 2022 Jul; 113(7): 2311–2322. Published online 2022 Jun 29. doi: 10.1111/cas.15391

PMCID:: PMC9277267

Abstract Article PDF–28M

Select item 916876215.

ARID1A‐deficient cells require HDAC6 for progression of endometrial carcinoma

Cristina Megino‐Luque, Pol Sisó, Natalia Mota‐Martorell, Raúl Navaridas, Inés de la Rosa, Izaskun Urdanibia, Manel Albertí‐Valls, Maria Santacana, Miquel Pinyol, Núria Bonifaci, Anna Macià, David Llobet‐Navas, Sònia Gatius, Xavier Matias‐Guiu, Núria Eritja

Mol Oncol. 2022 Jun; 16(11): 2235–2259. Published online 2022 Mar 2. doi: 10.1002/1878-0261.13193

PMCID:: PMC9168762

Abstract Article PDF–13M

Select item 910634416.

HDAC6 modulates myofibril stiffness and diastolic function of the heart

Ying-Hsi Lin, Jennifer L. Major, Tim Liebner, Zaynab Hourani, Joshua G. Travers, Sara A. Wennersten, Korey R. Haefner, Maria A. Cavasin, Cortney E. Wilson, Mark Y. Jeong, Yu Han, Michael Gotthardt, Scott K. Ferguson, Amrut V. Ambardekar, Maggie P.Y. Lam, Chunaram Choudhary, Henk L. Granzier, Kathleen C. Woulfe, Timothy A. McKinsey

J Clin Invest. 2022 May 16; 132(10): e148333. Published online 2022 May 16. doi: 10.1172/JCI148333

PMCID:: PMC9106344

Abstract Article PDF–4.5M

Select item 894777017.

Sulforaphane reduces obesity by reversing leptin resistance

Işın Çakır, Pauline Lining Pan, Colleen K Hadley, Abdulrahman El-Gamal, Amina Fadel, Dina Elsayegh, Omnia Mohamed, Nasser M Rizk, Masoud Ghamari-Langroudi

eLife. 2022; 11: e67368. Published online 2022 Mar 24. doi: 10.7554/eLife.67368

PMCID:: PMC8947770

Abstract Article PDF–1.1M

Select item 869290818.

HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity

Blake R McAlpin, Rajasekaran Mahalingam, Anand K Singh, Shruti Dharmaraj, Taylor T Chrisikos, Nabila Boukelmoune, Annemieke Kavelaars, Cobi J Heijnen

Theranostics. 2022; 12(2): 603–619. Published online 2022 Jan 1. doi: 10.7150/thno.67410

PMCID:: PMC8692908

Abstract Article PDF–2.5M

Select item 864180119.

HDAC6 Activates ERK in Airway and Pulmonary Vascular Remodeling of Chronic Obstructive Pulmonary Disease

Yunchao Su, Weihong Han, Anita Kovacs-Kasa, Alexander D. Verin, Laszlo Kovacs

Am J Respir Cell Mol Biol. 2021 Dec; 65(6): 603–614. Published online 2021 Mar 30. doi: 10.1165/rcmb.2020-0520OC

PMCID:: PMC8641801

Abstract Article PDF–2.0M

Select item 856738620.

Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation

Valentina Poli, Victor Pui-Yan Ma, Marco Di Gioia, Achille Broggi, Mehdi Benamar, Qian Chen, Ralph Mazitschek, Stephen J. Haggarty, Talal A. Chatila, Jeffrey M. Karp, Ivan Zanoni

iScience. 2021 Nov 19; 24(11): 103256. Published online 2021 Oct 11. doi: 10.1016/j.isci.2021.103256

PMCID:: PMC8567386

Abstract Article PDF–3.2M

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