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Select item 112475071.

Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning

George R. Bjorklund, Katherina P. Rees, Kavya Balasubramanian, Lauren T. Hewitt, Kenji Nishimura, Jason M. Newbern

Dis Model Mech. 2024 Jun 1; 17(6): dmm050570. Published online 2024 Jul 2. doi: 10.1242/dmm.050570

PMCID:: PMC11247507

Abstract Article

Select item 109901562.

ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period

Mengge Sun, Yanjing Gao, Zhenmeiyu Li, Lin Yang, Guoping Liu, Zhejun Xu, Rongliang Guo, Yan You, Zhengang Yang

Proc Natl Acad Sci U S A. 2024 Mar 26; 121(13): e2314802121. Published online 2024 Mar 18. doi: 10.1073/pnas.2314802121

PMCID:: PMC10990156

Abstract Article PDF–13M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103297124.

Arteriovenous malformation Map2k1 mutation affects vasculogenesis

Christopher L. Sudduth, Patrick J. Smits, Matthew P. Vivero, Yu Sheng Cheng, Michal Ad, Dennis J. Konczyk, Joyce Bischoff, Matthew L. Warman, Arin K. Greene

Sci Rep. 2023; 13: 11074. Published online 2023 Jul 8. doi: 10.1038/s41598-023-35301-6

PMCID:: PMC10329712

Abstract Article PDF–1.8M

Select item 103078525.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 99186236.

Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice

Patrick J. Smits, Christopher L. Sudduth, Dennis J. Konczyk, Yu Sheng Cheng, Matthew Vivero, Harry Kozakewich, Matthew L. Warman, Arin K. Greene

Angiogenesis. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Angiogenesis. 2023 Feb; 26(1): 97–105. Published online 2022 Aug 16. doi: 10.1007/s10456-022-09853-6

PMCID:: PMC9918623

Abstract Article PDF–1.4M

Select item 96416637.

Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism

Hyuk Nam Kwon, Kristen Kurtzeborn, Vladislav Iaroshenko, Xing Jin, Abigail Loh, Nathalie Escande-Beillard, Bruno Reversade, Sunghyouk Park, Satu Kuure

Development. 2022 Oct 1; 149(19): dev200986. Published online 2022 Oct 3. doi: 10.1242/dev.200986

PMCID:: PMC9641663

Abstract Article

Select item 95191498.

7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

Hideaki Tomita, Kelly M Hines, Josi M Herron, Amy Li, David W Baggett, Libin Xu

eLife. 2022; 11: e67141. Published online 2022 Sep 16. doi: 10.7554/eLife.67141

PMCID:: PMC9519149

Abstract Article PDF–16M

Select item 94174169.

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein CH van der Meulen, Ren Xu, Matthew B Greenblatt, Jae-hyuck Shim

eLife. 2022; 11: e78069. Published online 2022 Aug 17. doi: 10.7554/eLife.78069

PMCID:: PMC9417416

Abstract Article PDF–5.4M

Select item 910274610.

Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney

Kristen Kurtzeborn, Hyuk Nam Kwon, Vladislav Iaroshenko, Imrul Faisal, Martin Ambrož, Xing Jin, Talha Qureshi, Jussi Kupari, Anneliis Ihermann-Hella, Juho Väänänen, Henna Tyynismaa, Iva Boušová, Sunghyouk Park, Satu Kuure

BMC Biol. 2022; 20: 112. Published online 2022 May 13. doi: 10.1186/s12915-022-01309-z

PMCID:: PMC9102746

Abstract Article PDF–2.6M

Select item 858032611.

Phase transition specified by a binary code patterns the vertebrate eye cup

Revathi Balasubramanian, Xuanyu Min, Peter M. J. Quinn, Quentin Lo Giudice, Chenqi Tao, Karina Polanco, Neoklis Makrides, John Peregrin, Michael Bouaziz, Yingyu Mao, Qian Wang, Bruna L. da Costa, Diego Buenaventura, Fen Wang, Liang Ma, Stephen H. Tsang, Pierre J. Fabre, Xin Zhang

Sci Adv. 2021 Nov; 7(46): eabj9846. Published online 2021 Nov 10. doi: 10.1126/sciadv.abj9846

PMCID:: PMC8580326

Abstract Article PDF–3.8M

Select item 854982612.

Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways

Peng Xu, Yongyan Dang, Luyang Wang, Xia Liu, Xiaolin Ren, Jun Gu, Mingyao Liu, Xing Dai, Xiyun Ye

Cancer Lett. Author manuscript; available in PMC 2021 Oct 27.

Published in final edited form as: Cancer Lett. 2016 Dec 28; 383(2): 161–170. Published online 2016 Sep 30. doi: 10.1016/j.canlet.2016.09.005

PMCID:: PMC8549826

Abstract Article PDF–2.7M

Select item 844039613.

TRIM15 and CYLD regulate ERK activation via lysine 63-linked polyubiquitination

Guixin Zhu, Meenhard Herlyn, Xiaolu Yang

Nat Cell Biol. Author manuscript; available in PMC 2022 Mar 8.

Published in final edited form as: Nat Cell Biol. 2021 Sep; 23(9): 978–991. Published online 2021 Sep 8. doi: 10.1038/s41556-021-00732-8

PMCID:: PMC8440396

Abstract Article PDF–6.2M

Select item 835323614.

Mek1 and Mek2 Functional Redundancy in Erythropoiesis

Laurent Beuret, Simon-Pierre Fortier-Beaulieu, Vincent Rondeau, Sophie Roy, Nicolas Houde, Karl Balabanian, Marion Espéli, Jean Charron

Front Cell Dev Biol. 2021; 9: 639022. Published online 2021 Jul 27. doi: 10.3389/fcell.2021.639022

PMCID:: PMC8353236

Abstract Article PDF–4.3M

Select item 832501915.

Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition

Michael C Holter, Lauren T Hewitt, Kenji J Nishimura, Sara J Knowles, George R Bjorklund, Shiv Shah, Noah R Fry, Katherina P Rees, Tanya A Gupta, Carter W Daniels, Guohui Li, Steven Marsh, David Michael Treiman, Michael Foster Olive, Trent R Anderson, Federico Sanabria, William D Snider, Jason M Newbern

Cereb Cortex. 2021 Jun; 31(6): 3064–3081. Published online 2021 Feb 11. doi: 10.1093/cercor/bhaa413

PMCID:: PMC8325019

Abstract Article PDF–3.0M

Select item 831323916.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 820224117.

Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer

Benjamin L. Shneider, Nahir Cortes-Santiago, Deborah A. Schady, Swapna Krishnamoorthy, Sundararajah Thevananther, Kimal Rajapakshe, Dimuthu Perera, Shixia Huang, Cristian Coarfa

Am J Physiol Gastrointest Liver Physiol. 2021 Mar 1; 320(3): G366–G379. Published online 2021 Jan 20. doi: 10.1152/ajpgi.00065.2020

PMCID:: PMC8202241

Abstract Article

Select item 818733118.

VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9 dependent pathway

Ming Jiang, Yinshan Fang, Yu Li, Huachao Huang, Zichen Wei, Xia Gao, Hoon-Ki Sung, Jim Hu, Li Qiang, Jian Ruan, Qixuan Chen, Dianhua Jiang, Jeffrey A. Whitsett, Xingbin Ai, Jianwen Que

Dev Cell. Author manuscript; available in PMC 2022 Jun 7.

Published in final edited form as: Dev Cell. 2021 Jun 7; 56(11): 1646–1660.e5. Published online 2021 May 18. doi: 10.1016/j.devcel.2021.04.027

PMCID:: PMC8187331

Abstract Article PDF–3.5M

Select item 793877019.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 771827620.

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Sanja Pajovic, Robert Siddaway, Taylor Bridge, Javal Sheth, Patricia Rakopoulos, Byungjin Kim, Scott Ryall, Sameer Agnihotri, Lauren Phillips, Man Yu, Christopher Li, Scott Milos, Palak Patel, Dilakshan Srikanthan, Annie Huang, Cynthia Hawkins

Nat Commun. 2020; 11: 6216. Published online 2020 Dec 4. doi: 10.1038/s41467-020-19972-7

PMCID:: PMC7718276

Abstract Article PDF–2.5M

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