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Select item 110228941.

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah, Janne T. Backman

Drug Metab Dispos. 2019 Apr; 47(4): 436–443. Published online 2019 Apr. doi: 10.1124/dmd.118.085498

PMCID:: PMC11022894

Abstract Article PDF–1.2M

Select item 104877872.

Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients

Evelyn Incze, Katalin Mangó, Ferenc Fekete, Ádám Ferenc Kiss, Ádám Póti, Tünde Harkó, Judit Moldvay, Dávid Szüts, Katalin Monostory

Int J Mol Sci. 2023 Sep; 24(17): 13380. Published online 2023 Aug 29. doi: 10.3390/ijms241713380

PMCID:: PMC10487787

Abstract Article PDF–1.1M

Select item 101783503.

Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F)

Yoo-Bin Lee, Vitchan Kim, Sung-Gyu Lee, Gyu-Hyeong Lee, Changmin Kim, Eunseo Jeong, Donghak Kim

Int J Mol Sci. 2023 May; 24(9): 8032. Published online 2023 Apr 28. doi: 10.3390/ijms24098032

PMCID:: PMC10178350

Abstract Article PDF–3.5M

Select item 95549544.

The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility

Weixing Qu, Fuzhou Zhang, Yongyi Cheng, Jing Li, Jiancheng Zhou

Front Endocrinol (Lausanne) 2022; 13: 989030. Published online 2022 Sep 28. doi: 10.3389/fendo.2022.989030

PMCID:: PMC9554954

Abstract Article PDF–715K

Select item 93632735.

The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals

Sigrid Haeggström, Magnus Ingelman-Sundberg, Svante Pääbo, Hugo Zeberg

Pharmacogenomics J. 2022; 22(4): 247–249. Published online 2022 Jul 2. doi: 10.1038/s41397-022-00284-6

PMCID:: PMC9363273

Abstract Article PDF–410K

Select item 90698736.

CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project

Andrea Gaedigk, Erin C. Boone, Steven E. Scherer, Seung-been Lee, Ibrahim Numanagić, Cenk Sahinalp, Joshua D. Smith, Sean McGee, Aparna Radhakrishnan, Xiang Qin, Wendy Y. Wang, Emily G. Farrow, Nina Gonzaludo, Aaron L. Halpern, Deborah A. Nickerson, Neil A. Miller, Victoria M. Pratt, Lisa V. Kalman

J Mol Diagn. 2022 Apr; 24(4): 337–350. doi: 10.1016/j.jmoldx.2021.12.011

PMCID:: PMC9069873

Abstract Article PDF–1.4M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 77227898.

CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer

Kezhi Li, Yonglun Chen

Cancer Biol Ther. 2020; 21(12): 1145–1153. Published online 2020 Nov 12. doi: 10.1080/15384047.2020.1840886

PMCID:: PMC7722789

Abstract Article PDF–8.7M

Select item 73179979.

Influence of CYP2C8, CYP3A4, and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax

Anne C. G. Almeida, Maria C. B. Puça, Erick F. G. Figueiredo, Laila R. Barbosa, Yanka E. A. R. Salazar, Emanuelle L. Silva, Marcelo A. M. Brito, André M. Siqueira, José L. F. Vieira, Marcus V. G. Lacerda, Wuelton M. Monteiro, Gisely C. Melo

Antimicrob Agents Chemother. 2020 Jul; 64(7): e02125-19. Prepublished online 2020 May 4. Published online 2020 Jun 23. doi: 10.1128/AAC.02125-19

PMCID:: PMC7317997

Abstract Article PDF–862K

Select item 676958610.

Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling

William R. Arnold, Susan Zelasko, Daryl D. Meling, Kimberly Sam, Aditi Das

Int J Mol Sci. 2019 Sep; 20(18): 4626. Published online 2019 Sep 18. doi: 10.3390/ijms20184626

PMCID:: PMC6769586

Abstract Article PDF–1.3M

Select item 656294311.

Patients carrying CYP2C8*3 have shorter systemic paclitaxel exposure

Lauren A Marcath, Kelley M Kidwell, Adam C Robinson, Kiran Vangipuram, Monika L Burness, Jennifer J Griggs, Catherine Van Poznak, Anne F Schott, Daniel F Hayes, Norah Lynn Henry, Daniel L Hertz

Pharmacogenomics. 2019 Jan; 20(2): 95–104. Published online 2018 Dec 6. doi: 10.2217/pgs-2018-0162

PMCID:: PMC6562943

Abstract Article PDF–492K

Select item 594752312.

Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP

Ming‐Liang Tan, Kenta Yoshida, Ping Zhao, Lei Zhang, Thomas D. Nolin, Micheline Piquette‐Miller, Aleksandra Galetin, Shiew‐Mei Huang

Clin Pharmacol Ther. 2018 May; 103(5): 854–867. Published online 2017 Oct 9. doi: 10.1002/cpt.807

PMCID:: PMC5947523

Abstract Article PDF–603K

Select item 512981713.

Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients

Siu W Lam, Charlotte N Frederiks, Tahar van der Straaten, Aafke H Honkoop, Henk-Jan Guchelaar, Epie Boven

Br J Cancer. 2016 Nov 22; 115(11): 1335–1342. Published online 2016 Oct 13. doi: 10.1038/bjc.2016.326

PMCID:: PMC5129817

Abstract Article PDF–237K

Select item 506593414.

Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke

Xingyang Yi, Lang Wu, Duanxiu Liao, Chun Wang, Biao Zhang

J Atheroscler Thromb. 2016 Nov 1; 23(11): 1286–1293. doi: 10.5551/jat.35279

PMCID:: PMC5065934

Abstract Article PDF–115K

Select item 501017615.

Cytochrome P450 oxidase 2C inhibition adds to ω-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal neovascularization

Yan Gong, Zhongjie Fu, Matthew L. Edin, Chi-Hsiu Liu, Zhongxiao Wang, Zhuo Shao, Thomas W. Fredrick, Nicholas J. Saba, Peyton C. Morss, Samuel B. Burnim, Steven S. Meng, Fred B. Lih, Kin Sing Stephen Lee, Elizabeth P. Moran, John Paul SanGiovanni, Ann Hellström, Bruce D. Hammock, Darryl C. Zeldin, Lois E. H. Smith

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9): 1919–1927. Published online 2016 Jul 14. doi: 10.1161/ATVBAHA.116.307558

PMCID:: PMC5010176

Abstract Article PDF–1.3M

Select item 442674316.

Genetic markers in the EET metabolic pathway are associated with outcomes in patients with aneurysmal subarachnoid hemorrhage

Mark K Donnelly, Yvette P Conley, Elizabeth A Crago, Dianxu Ren, Paula R Sherwood, Jeffery R Balzer, Samuel M Poloyac

J Cereb Blood Flow Metab. 2015 Feb; 35(2): 267–276. Published online 2014 Nov 12. doi: 10.1038/jcbfm.2014.195

PMCID:: PMC4426743

Abstract Article PDF–643K

Select item 438092817.

Phospho-tyrosine dependent protein–protein interaction network

Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl

Mol Syst Biol. 2015 Mar; 11(3): 0794. Published online 2015 Mar 26. doi: 10.15252/msb.20145968

PMCID:: PMC4380928

Abstract Article PDF–1.9M

Select item 425615318.

Genetic Heterogeneity Beyond CYP2C8*3 Does Not Explain Differential Sensitivity to Paclitaxel-Induced Neuropathy

Daniel L. Hertz, Siddharth Roy, John Jack, Alison A. Motsinger-Reif, Amy Drobish, L. Scott Clark, Lisa A. Carey, E. Claire Dees, Howard L. McLeod

Breast Cancer Res Treat. Author manuscript; available in PMC 2014 Dec 4.

Published in final edited form as: Breast Cancer Res Treat. 2014 May; 145(1): 245–254. Published online 2014 Apr 6. doi: 10.1007/s10549-014-2910-1

PMCID:: PMC4256153

Abstract Article PDF–628K

Select item 424723819.

Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer

Xiaolong Wei, Donghong Zhang, Xiaowei Dou, Na Niu, Wenhe Huang, Jingwen Bai, Guojun Zhang

BMC Cancer. 2014; 14: 841. Published online 2014 Nov 18. doi: 10.1186/1471-2407-14-841

PMCID:: PMC4247238

Abstract Article PDF–1.0M

Select item 420797720.

Targeting of Splice Variants of Human Cytochrome P450 2C8 (CYP2C8) to Mitochondria and Their Role in Arachidonic Acid Metabolism and Respiratory Dysfunction

Prachi Bajpai, Satish Srinivasan, Jyotirmoy Ghosh, Leslie D. Nagy, Shouzou Wei, F. Peter Guengerich, Narayan G. Avadhani

J Biol Chem. 2014 Oct 24; 289(43): 29614–29630. Published online 2014 Aug 26. doi: 10.1074/jbc.M114.583062

PMCID:: PMC4207977

Abstract Article PDF–3.8M

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