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Items: 1 to 20 of 168

1.
BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway
Elena Prosdocimi, Veronica Carpanese, Luca Matteo Todesca, Tatiana Varanita, Magdalena Bachmann, Margherita Festa, Daniele Bonesso, Mireia Perez-Verdaguer, Andrea Carrer, Angelo Velle, Roberta Peruzzo, Silvia Muccioli, Davide Doni, Luigi Leanza, Paola Costantini, Frank Stein, Mandy Rettel, Antonio Felipe, Michael J. Edwards, Erich Gulbins, Laura Cendron, Chiara Romualdi, Vanessa Checchetto, Ildiko Szabo
Sci Adv. 2024 Sep 6; 10(36): eadn9361. Published online 2024 Sep 4. doi: 10.1126/sciadv.adn9361
PMCID:
PMC11373599
AbstractArticlePDF–11M
2.
Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV
Cagla Akay-Espinoza, Sarah E.B. Newton, Beth A. Dombroski, Asha Kallianpur, Ajay Bharti, Donald R. Franklin, Gerard D. Schellenberg, Robert K. Heaton, Igor Grant, Ronald J. Ellis, Scott L. Letendre, Kelly L. Jordan-Sciutto
J Neuroimmune Pharmacol. 2024; 19(1): 25. Published online 2024 May 25. doi: 10.1007/s11481-024-10125-x
PMCID:
PMC11126443
AbstractArticlePDF–1.5M
3.
ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton
Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012
PMCID:
PMC10990277
AbstractArticlePDF–3.9M
4.
DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response
Minjing Li, Xingli Wu, Meiyang Chen, Shiyu Hao, Yue Yu, Xiang Li, Erdi Zhao, Ming Xu, Zhenhai Yu, Zhiqiang Wang, Ning Xu, Changzhu Jin, Yancun Yin
Haematologica. 2024 Mar 1; 109(3): 751–764. Published online 2023 Jul 27. doi: 10.3324/haematol.2023.282691
PMCID:
PMC10905105
AbstractArticlePDF–3.8M
5.
The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells
Fang Liu, Zhun Liu, Weisheng Cheng, Qingquan Zhao, Xinyu Zhang, He Zhang, Miao Yu, He Xu, Yichen Gao, Qianrui Jiang, Guojun Shi, Likun Wang, Shanshan Gu, Jia Wang, Nan Cao, Zhongyan Chen
Adv Sci (Weinh) 2023 Dec; 10(35): 2303799. Published online 2023 Oct 27. doi: 10.1002/advs.202303799
PMCID:
PMC10724406
AbstractArticlePDF–11M
6.
Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation
Suravi Majumder, Abhijnan Chattopadhyay, Jamie M. Wright, Pujun Guan, L. Maximilian Buja, Callie S. Kwartler, Dianna M. Milewicz
JCI Insight. 2023 Nov 8; 8(21): e173247. Published online 2023 Nov 8. doi: 10.1172/jci.insight.173247
PMCID:
PMC10721278
AbstractArticlePDF–21M
7.
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis
Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley
J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295
PMCID:
PMC10641524
AbstractArticlePDF–3.8M
8.
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis
Alexandre Janer, Jordan L Morris, Michiel Krols, Hana Antonicka, Mari J Aaltonen, Zhen-Yuan Lin, Hanish Anand, Anne-Claude Gingras, Julien Prudent, Eric A Shoubridge
Life Sci Alliance. 2024 Jan; 7(1): e202302335. Published online 2023 Nov 6. doi: 10.26508/lsa.202302335
PMCID:
PMC10627786
AbstractArticlePDF–5.2M
9.
SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1
Pengtao Jiao, Wenhui Fan, Xiaoya Ma, Runshan Lin, Yuna Zhao, Yabo Li, He Zhang, Xiaojuan Jia, Yuhai Bi, Xiaoli Feng, Minghua Li, Wenjun Liu, Ke Zhang, Lei Sun
Autophagy. 2023; 19(12): 3113–3131. Published online 2023 Jul 23. doi: 10.1080/15548627.2023.2238579
PMCID:
PMC10621274
AbstractArticlePDF–5.8M
10.
Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer
Krishan Kumar Saini, Priyank Chaturvedi, Abhipsa Sinha, Manish Pratap Singh, Muqtada Ali Khan, Ayushi Verma, Mushtaq Ahmad Nengroo, Saumya Ranjan Satrusal, Sanjeev Meena, Akhilesh Singh, Sameer Srivastava, Jayanta Sarkar, Dipak Datta
Redox Biol. 2023 Sep; 65: 102833. Published online 2023 Jul 28. doi: 10.1016/j.redox.2023.102833
PMCID:
PMC10412847
AbstractArticlePDF–11M
11.
PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia
Tao Wang, Yunxia Zhou, Yunping Fan, Hao Duan, Xiaoyu Guo, Jinlong Chang, Youheng Jiang, Changxue Li, Zhang Fu, Yunfei Gao, Xiaoran Guo, Kastytis Sidlauskas, Zhenqiang He, Clive Da Costa, Xia Sheng, Dinglan Wu, Jinqiu Yuan, Huiliang Li, Yulong He, Yonggao Mou, Ningning Li
Adv Sci (Weinh) 2023 Jul; 10(20): 2205949. Published online 2023 May 11. doi: 10.1002/advs.202205949
PMCID:
PMC10369258
AbstractArticlePDF–9.7M
12.
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest
Bipul R Acharya, Jennifer S Fang, Erin D Jeffery, Nicholas W Chavkin, Gael Genet, Hema Vasavada, Elizabeth A Nelson, Gloria M Sheynkman, Martin J Humphries, Karen K Hirschi
Life Sci Alliance. 2023 Aug; 6(8): e202201685. Published online 2023 May 17. doi: 10.26508/lsa.202201685
PMCID:
PMC10192821
AbstractArticlePDF–3.0M
13.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
14.
Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice
Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori
Mol Biol Cell. 2023 Mar 1; 34(3): ar20. Published online 2023 Feb 21. doi: 10.1091/mbc.E22-07-0292
PMCID:
PMC10011727
AbstractArticlePDF–11M
15.
PERK recruits E-Syt1 at ER–mitochondria contacts for mitochondrial lipid transport and respiration
Maria Livia Sassano, Alexander R. van Vliet, Ellen Vervoort, Sofie Van Eygen, Chris Van den Haute, Benjamin Pavie, Joris Roels, Johannes V. Swinnen, Marco Spinazzi, Leen Moens, Kristina Casteels, Isabelle Meyts, Paolo Pinton, Saverio Marchi, Leila Rochin, Francesca Giordano, Blanca Felipe-Abrio, Patrizia Agostinis
J Cell Biol. 2023 Mar 6; 222(3): e202206008. Published online 2023 Feb 23. doi: 10.1083/jcb.202206008
PMCID:
PMC9998969
AbstractArticlePDF–7.3M
16.
Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation
Goonho Park, Ke Xu, Leon Chea, Kyle Kim, Lance Safarta, Keon-Hyoung Song, Jian Wu, Soyoung Park, Hyejung Min, Nobuhiko Hiramatsu, Jaeseok Han, Jonathan H. Lin
J Biol Chem. 2023 Feb; 299(2): 102821. Published online 2022 Dec 21. doi: 10.1016/j.jbc.2022.102821
PMCID:
PMC9852698
AbstractArticlePDF–2.8M
17.
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality
Arti T. Navare, Fred D. Mast, Jean Paul Olivier, Thierry Bertomeu, Maxwell L. Neal, Lindsay N. Carpp, Alexis Kaushansky, Jasmin Coulombe-Huntington, Mike Tyers, John D. Aitchison
J Cell Biol. 2022 Nov 7; 221(11): e202011050. Published online 2022 Oct 28. doi: 10.1083/jcb.202011050
PMCID:
PMC9623979
AbstractArticlePDF–3.7M
18.
PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells
Neil Saptarshi, Louise F. Porter, Luminita Paraoan
Sci Rep. 2022; 12: 13324. Published online 2022 Aug 3. doi: 10.1038/s41598-022-16909-6
PMCID:
PMC9349321
AbstractArticlePDF–4.1M
19.
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1
Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen
Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119
PMCID:
PMC9231623
AbstractArticlePDF–6.0M
20.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M

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