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Items: 1 to 20 of 42

1.
HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes
Kentaro Akagi, Shiro Baba, Hiroaki Fujita, Yasuhiro Fuseya, Daisuke Yoshinaga, Hirohito Kubota, Eitaro Kume, Fumiaki Fukumura, Koichi Matsuda, Takayuki Tanaka, Takuya Hirata, Megumu K. Saito, Kazuhiro Iwai, Junko Takita
Sci Rep. 2024; 14: 8871. Published online 2024 Apr 17. doi: 10.1038/s41598-024-57504-1
Correction in:
Sci Rep. 2024; 14: 10331.
PMCID:
PMC11024103
AbstractArticlePDF–4.4M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency
Silvia Nitschke, Mitchell A Sullivan, Sharmistha Mitra, Charlotte R Marchioni, Jennifer P  Y Lee, Brandon H Smith, Saija Ahonen, Jun Wu, Erin E Chown, Peixiang Wang, Sara Petković, Xiaochu Zhao, Laura F DiGiovanni, Ami M Perri, Lori Israelian, Tamar R Grossman, Holly Kordasiewicz, Francisco Vilaplana, Kazuhiro Iwai, Felix Nitschke, Berge A Minassian
Brain. 2022 Jul; 145(7): 2361–2377. Published online 2022 Jan 27. doi: 10.1093/brain/awac017
PMCID:
PMC9612801
AbstractArticlePDF–2.9M
4.
HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine
Matthew J. Wood, Jeffrey N. Marshall, Victoria L. Hartley, Ta-Chiang Liu, Kazuhiro Iwai, Thaddeus S. Stappenbeck, Donna A. MacDuff
Mucosal Immunol. 2022; 15(4): 642–655. Published online 2022 May 9. doi: 10.1038/s41385-022-00520-z
PMCID:
PMC9259497
AbstractArticlePDF–11M
5.
HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation
Ian R Kelsall, Elisha H McCrory, Yingqi Xu, Cheryl L Scudamore, Sambit K Nanda, Paula Mancebo‐Gamella, Nicola T Wood, Axel Knebel, Stephen J Matthews, Philip Cohen
EMBO J. 2022 Apr; 41(8): e109700. Published online 2022 Mar 11. doi: 10.15252/embj.2021109700
PMCID:
PMC9016349
AbstractArticlePDF–4.3M
6.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
7.
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains
Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
iScience. 2021 Nov 19; 24(11): 103241. Published online 2021 Oct 8. doi: 10.1016/j.isci.2021.103241
PMCID:
PMC8561004
AbstractArticlePDF–4.4M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection
Patricia L. Brazee, Luisa Morales-Nebreda, Natalia D. Magnani, Joe G.N. Garcia, Alexander V. Misharin, Karen M. Ridge, G.R. Scott Budinger, Kazuhiro Iwai, Laura A. Dada, Jacob I. Sznajder
J Clin Invest. 2020 Mar 2; 130(3): 1301–1314. Published online 2020 Jan 27. doi: 10.1172/JCI128368
PMCID:
PMC7269564
AbstractArticlePDF–1.9M
10.
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
Yibo Zuo, Qian Feng, Lincong Jin, Fan Huang, Ying Miao, Jin Liu, Ying Xu, Xiangjie Chen, Hongguang Zhang, Tingting Guo, Yukang Yuan, Liting Zhang, Jun Wang, Hui Zheng
Nat Commun. 2020; 11: 1146. Published online 2020 Mar 2. doi: 10.1038/s41467-020-14948-z
PMCID:
PMC7052135
AbstractArticlePDF–3.5M
11.
The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells
Ian R. Kelsall, Jiazhen Zhang, Axel Knebel, J. Simon C. Arthur, Philip Cohen
Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13293–13298. Published online 2019 Jun 17. doi: 10.1073/pnas.1905873116
PMCID:
PMC6613137
AbstractArticlePDF–1.0M
12.
Tumour necrosis factor signalling in health and disease
Jonathan Holbrook, Samuel Lara-Reyna, Heledd Jarosz-Griffiths, Michael F. McDermott
Version 1. F1000Res. 2019; 8: F1000 Faculty Rev-111. Published online 2019 Jan 28. doi: 10.12688/f1000research.17023.1
PMCID:
PMC6352924
AbstractArticlePDF–1.8M
13.
HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection
Donna A. MacDuff, Megan T. Baldridge, Arwa M. Qaqish, Timothy J. Nice, Azad D. Darbandi, Victoria L. Hartley, Stefan T. Peterson, Jonathan J. Miner, Kazuhiro Iwai, Herbert W. Virgin
J Virol. 2018 Dec 1; 92(23): e01368-18. Prepublished online 2018 Sep 12. Published online 2018 Nov 12. doi: 10.1128/JVI.01368-18
PMCID:
PMC6232484
AbstractArticlePDF–1.7M
14.
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak
Nat Commun. 2018; 9: 3910. Published online 2018 Sep 25. doi: 10.1038/s41467-018-06155-8
PMCID:
PMC6156229
AbstractArticlePDF–3.3M
15.
Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization
Hiroaki Fujita, Akira Tokunaga, Satoshi Shimizu, Amanda L. Whiting, Francisco Aguilar-Alonso, Kenji Takagi, Erik Walinda, Yoshiteru Sasaki, Taketo Shimokawa, Tsunehiro Mizushima, Izuru Ohki, Mariko Ariyoshi, Hidehito Tochio, Federico Bernal, Masahiro Shirakawa, Kazuhiro Iwai
Cell Rep. Author manuscript; available in PMC 2019 Apr 24.
Published in final edited form as: Cell Rep. 2018 Apr 24; 23(4): 1192–1204. doi: 10.1016/j.celrep.2018.03.112
PMCID:
PMC6044281
AbstractArticlePDF–1.0M
16.
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L. Haas, Yutaka Shimizu, Charlotta Böiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T. Ashworth, Allison Beal, Tariq Enver, John Bertin, William Kaiser, Andreas Strasser, John Silke, Philippe Bouillet, Henning Walczak
Nature. Author manuscript; available in PMC 2018 Oct 25.
Published in final edited form as: Nature. 2018 May; 557(7703): 112–117. Published online 2018 Apr 25. doi: 10.1038/s41586-018-0064-8
PMCID:
PMC5947819
AbstractArticlePDF–5.6M
17.
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy
Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon
eLife. 2018; 7: e32866. Published online 2018 Apr 20. doi: 10.7554/eLife.32866
PMCID:
PMC5927771
AbstractArticlePDF–9.1M
18.
HIF and HOIL-1L–mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury
Natalia D. Magnani, Laura A. Dada, Markus A. Queisser, Patricia L. Brazee, Lynn C. Welch, Kishore R. Anekalla, Guofei Zhou, Olga Vagin, Alexander V. Misharin, G. R. Scott Budinger, Kazuhiro Iwai, Aaron J. Ciechanover, Jacob I. Sznajder
Proc Natl Acad Sci U S A. 2017 Nov 21; 114(47): E10178–E10186. Published online 2017 Nov 6. doi: 10.1073/pnas.1713563114
PMCID:
PMC5703319
AbstractArticlePDF–1.7M
19.
Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection
Satoshi Shimizu, Hiroaki Fujita, Yoshiteru Sasaki, Tatsuaki Tsuruyama, Kazuhiko Fukuda, Kazuhiro Iwai
Mol Cell Biol. 2016 May 15; 36(10): 1569–1583. Prepublished online 2016 Mar 14. Published online 2016 May 2. doi: 10.1128/MCB.01049-15
PMCID:
PMC4859691
AbstractArticlePDF–5.9M
20.
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling
Theo Klein, Shan-Yu Fung, Florian Renner, Michael A. Blank, Antoine Dufour, Sohyeong Kang, Madison Bolger-Munro, Joshua M. Scurll, John J. Priatel, Patrick Schweigler, Samu Melkko, Michael R. Gold, Rosa I. Viner, Catherine H. Régnier, Stuart E. Turvey, Christopher M. Overall
Nat Commun. 2015; 6: 8777. Published online 2015 Nov 3. doi: 10.1038/ncomms9777
PMCID:
PMC4659944
AbstractArticlePDF–5.2M

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