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Select item 112039201.

Mitochondrial DNA Instability Supersedes Parkin Mutations in Driving Mitochondrial Proteomic Alterations and Functional Deficits in Polg Mutator Mice

Andrew J. Trease, Steven Totusek, Eliezer Z. Lichter, Kelly L. Stauch, Howard S. Fox

Int J Mol Sci. 2024 Jun; 25(12): 6441. Published online 2024 Jun 11. doi: 10.3390/ijms25126441

PMCID:: PMC11203920

Abstract Article PDF–4.4M

Select item 109287182.

Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication

Li Zhou, Ruochuan Liu, Heather Pathak, Xiaoyu Wang, Geon H. Jeong, Pratima Kumari, Mukesh Kumar, Jun Yin

ACS Infect Dis. 2024 Mar 8; 10(3): 879–889. Published online 2024 Feb 22. doi: 10.1021/acsinfecdis.3c00418

PMCID:: PMC10928718

Abstract Article PDF–4.9M

Select item 108898663.

The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease

Anne Ward, Forrest Jessop, Robert Faris, Jason Hollister, Daniel Shoup, Brent Race, Catharine M. Bosio, Suzette A. Priola

PLoS One. 2024; 19(2): e0298095. Published online 2024 Feb 23. doi: 10.1371/journal.pone.0298095

PMCID:: PMC10889866

Abstract Article PDF–4.4M

Select item 108084134.

Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice

Alejandro Delgado-Anglés, Albert Blasco-Roset, Francisco J. Godoy-Nieto, Montserrat Cairó, Francesc Villarroya, Marta Giralt, Joan Villarroya

J Physiol Biochem. 2024; 80(1): 41–51. Published online 2023 Nov 2. doi: 10.1007/s13105-023-00977-x

PMCID:: PMC10808413

Abstract Article PDF–3.1M

Select item 106964005.

Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin–Mediated Mitophagy

Yu Zhang, Ziyi Wang, Chenyang Jia, Wenjie Yu, Xiangdong Li, Nan Xia, Huiling Nie, Likalamu Pascalia Wikana, Minhao Chen, Yong Ni, Sheng Han, Liyong Pu

Cell Mol Gastroenterol Hepatol. 2024; 17(1): 149–169. Published online 2023 Sep 16. doi: 10.1016/j.jcmgh.2023.09.004

PMCID:: PMC10696400

Abstract Article PDF–13M

Select item 105889816.

C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy

Hui Zhang, Chan Li, Qingyang Liu, Jingmei Li, Hao Wu, Rui Xu, Yidan Sun, Ming Cheng, Xiaoe Zhao, Menghao Pan, Qiang Wei, Baohua Ma

eLife. 2023; 12: RP88523. Published online 2023 Oct 20. doi: 10.7554/eLife.88523

PMCID:: PMC10588981

Abstract Article PDF–9.3M

Select item 104670417.

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

Xu Hou, Taylor Hsuan‐Yu Chen, Shunsuke Koga, Jenny M. Bredenberg, Ayman H. Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K. Wszolek, Jonathan A. Carr, Owen A. Ross, Pamela J. McLean, Melissa E. Murray, Dennis W. Dickson, Fabienne C. Fiesel, Wolfdieter Springer

Brain Pathol. 2023 Sep; 33(5): e13175. Published online 2023 May 31. doi: 10.1111/bpa.13175

PMCID:: PMC10467041

Abstract Article PDF–2.9M

Select item 103491118.

Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency

K. L. Stauch, S. Totusek, A. J. Trease, L. D. Estrella, K. Emanuel, A. Fangmeier, H. S. Fox

Sci Rep. 2023; 13: 11414. Published online 2023 Jul 14. doi: 10.1038/s41598-023-38484-0

PMCID:: PMC10349111

Abstract Article PDF–5.7M

Select item 103061929.

Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages

Rachel L. Kinsella, Jacqueline M. Kimmey, Asya Smirnov, Reilly Woodson, Margaret R. Gaggioli, Sthefany M. Chavez, Darren Kreamalmeyer, Christina L. Stallings

PLoS Biol. 2023 Jun; 21(6): e3002159. Published online 2023 Jun 15. doi: 10.1371/journal.pbio.3002159

PMCID:: PMC10306192

Abstract Article PDF–1.8M

Select item 1026516410.

Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease

Yi‐Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi‐Hao Lin, Nai‐Jia Xue, Ying Chen, Bao‐Rong Zhang, Jia‐Li Pu

Aging Cell. 2023 Jun; 22(6): e13834. Published online 2023 Apr 7. doi: 10.1111/acel.13834

PMCID:: PMC10265164

Abstract Article PDF–11M

Select item 1025965011.

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates

Hideaki Matsui, Roberto Gavinio, Takeshi Asano, Norihito Uemura, Hidefumi Ito, Yoshihito Taniguchi, Yoshito Kobayashi, Takakuni Maki, Jie Shen, Shunichi Takeda, Kengo Uemura, Hodaka Yamakado, Ryosuke Takahashi

Hum Mol Genet. 2013 Jun 15; 22(12): 2423–2434. Published online 2013 Feb 27. doi: 10.1093/hmg/ddt095

PMCID:: PMC10259650

Abstract Article PDF–785K

Select item 1017234412.

Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis

R. Undamatla, O. G. Fagunloye, J. Chen, L. R. Edmunds, A. Murali, A. Mills, B. Xie, M. M. Pangburn, I. Sipula, G. Gibson, C. St. Croix, M. J. Jurczak

Sci Rep. 2023; 13: 7575. Published online 2023 May 10. doi: 10.1038/s41598-023-34710-x

PMCID:: PMC10172344

Abstract Article PDF–2.5M

Select item 1011716513.

Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease

Willcyn Tang, John Thundyil, Grace Gui Yin Lim, Teddy J W Tng, Sean Qing Zhang Yeow, Aditya Nair, Chou Chai, Tso-Pang Yao, Kah-Leong Lim

Hum Mol Genet. 2023 May 1; 32(9): 1466–1482. Published online 2022 Nov 26. doi: 10.1093/hmg/ddac297

Correction in:: Hum Mol Genet. 2023 Jun 1; 32(11): 1943.

PMCID:: PMC10117165

Abstract Article PDF–2.3M

Select item 1002065714.

RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy

Joanne Ern Chi Soh, Akio Shimizu, Md Rasel Molla, Dimitar P. Zankov, Le Kim Chi Nguyen, Mahbubur Rahman Khan, Wondwossen Wale Tesega, Si Chen, Misa Tojo, Yoshito Ito, Akira Sato, Masahito Hitosugi, Shigeru Miyagawa, Hisakazu Ogita

J Biol Chem. 2023 Mar; 299(3): 102993. Published online 2023 Feb 8. doi: 10.1016/j.jbc.2023.102993

PMCID:: PMC10020657

Abstract Article PDF–6.6M

Select item 1000868915.

Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

Qisheng Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chaojun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Minfang Zhang, Jiayi Cheng, Leyi Gu, Shan Mou, Zhaohui Ni

Int J Biol Sci. 2023; 19(4): 1192–1210. Published online 2023 Feb 13. doi: 10.7150/ijbs.80775

PMCID:: PMC10008689

Abstract Article PDF–15M

Select item 999370316.

Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity

Eun-Young Kim, Ji-Eun Kim, Young-Eun Kim, Bongkun Choi, Dong Hyun Sohn, Si-On Park, Yeon-Ho Chung, Yongsub Kim, William H. Robinson, Yong-Gil Kim, Eun-Ju Chang

Cell Biosci. 2023; 13: 48. Published online 2023 Mar 7. doi: 10.1186/s13578-023-00973-0

PMCID:: PMC9993703

Abstract Article PDF–10M

Select item 999014617.

PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease

Areum Jo, Yunjong Lee, Tae-In Kam, Sung-Ung Kang, Stewart Neifert, Senthilkumar S. Karuppagounder, Rin Khang, Hojin Kang, Hyejin Park, Shih-Ching Chou, Sungtaek Oh, Haisong Jiang, Deborah A. Swing, Sangwoo Ham, Sheila Pirooznia, George K. E. Umanah, Xiaobo Mao, Manoj Kumar, Han Seok Ko, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Shaida A. Andrabi, Chi-Hu Park, Ji-Yeong Lee, Hanna Kim, Hyein Kim, Hyojung Kim, Jin Whan Cho, Sun Ha Paek, Chan Hyun Na, Lino Tessarollo, Valina L. Dawson, Ted M. Dawson, Joo-Ho Shin

Sci Transl Med. Author manuscript; available in PMC 2023 Mar 7.

Published in final edited form as: Sci Transl Med. 2021 Jul 28; 13(604): eaax8891. doi: 10.1126/scitranslmed.aax8891

PMCID:: PMC9990146

Abstract Article PDF–3.4M

Select item 990506118.

PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products

Wei Li, Wang-Sheng Jiang, Ya-Ru Su, Ke-Wu Tu, Lin Zou, Cong-Rui Liao, Qian Wu, Zi-Han Wang, Zhao-Ming Zhong, Jian-Ting Chen, Si-Yuan Zhu

Cell Death Dis. 2023 Feb; 14(2): 88. Published online 2023 Feb 7. doi: 10.1038/s41419-023-05595-5

PMCID:: PMC9905061

Abstract Article PDF–7.4M

Select item 989825219.

Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis

Ne N. Wu, Lifeng Wang, Lu Wang, Xihui Xu, Gary D. Lopaschuk, Yingmei Zhang, Jun Ren

Exp Mol Med. 2023 Jan; 55(1): 269–280. Published online 2023 Jan 19. doi: 10.1038/s12276-022-00923-9

PMCID:: PMC9898252

Abstract Article PDF–5.9M

Select item 986953520.

Parkin coregulates glutathione metabolism in adult mammalian brain

Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher

Acta Neuropathol Commun. 2023; 11: 19. Published online 2023 Jan 23. doi: 10.1186/s40478-022-01488-4

PMCID:: PMC9869535

Abstract Article PDF–2.6M

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