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Select item 112065341.

The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment

Szilvia Juhász, Rebecca Smith, Tamás Schauer, Dóra Spekhardt, Hasan Mamar, Siham Zentout, Catherine Chapuis, Sébastien Huet, Gyula Timinszky

Sci Adv. 2020 Dec; 6(51): eabb8626. Published online 2020 Dec 18. doi: 10.1126/sciadv.abb8626

PMCID:: PMC11206534

Abstract Article PDF–2.9M

Select item 106173952.

Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population

Vanessa E. Schulz, Jeffrey F. Tuff, Riley H. Tough, Lara Lewis, Benjamin Chimukangara, Nigel Garrett, Quarraisha Abdool Karim, Salim S. Abdool Karim, Lyle R. McKinnon, Ayesha B. M. Kharsany, Paul J. McLaren

J Virol. 2023 Oct; 97(10): e00954-23. Published online 2023 Sep 25. doi: 10.1128/jvi.00954-23

PMCID:: PMC10617395

Abstract Article PDF–2.2M

Select item 105658763.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99501835.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 97725586.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 97696987.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 95403458.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 94819339.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 905883611.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 897411412.

Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells

Xueyao Zhang, Yingxian Sun

Bioengineered. 2022; 13(2): 2597–2609. Published online 2022 Jan 9. doi: 10.1080/21655979.2021.2019869

PMCID:: PMC8974114

Abstract Article PDF–4.1M

Select item 868308513.

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

Jugal Mohapatra, Kyuto Tashiro, Ryan L Beckner, Jorge Sierra, Jessica A Kilgore, Noelle S Williams, Glen Liszczak

eLife. 2021; 10: e71502. Published online 2021 Dec 7. doi: 10.7554/eLife.71502

PMCID:: PMC8683085

Abstract Article PDF–6.3M

Select item 852000614.

CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3

Xiaofeng Zhang, Yinshan Bai, Li Huang, Shanshan Liu, Yanxuan Mo, Wei Cheng, Guangliang Wang, Zhiming Cao, Xiaogang Chen, Huiqing Cui, Ling Qi, Lei Ma, Ming Liu, Xin-Yuan Guan, Ning-Fang Ma

Cell Death Dis. 2021 Oct; 12(10): 950. Published online 2021 Oct 15. doi: 10.1038/s41419-021-04254-x

PMCID:: PMC8520006

Abstract Article PDF–5.5M

Select item 848126915.

CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis

Guangliang Wang, Xiaofeng Zhang, Wei Cheng, Yanxuan Mo, Juan Chen, Zhiming Cao, Xiaogang Chen, Huiqin Cui, Shanshan Liu, Li Huang, Ming Liu, Lei Ma, Ning-Fang Ma

Cell Death Dis. 2021 Oct; 12(10): 891. Published online 2021 Sep 29. doi: 10.1038/s41419-021-04167-9

Correction in:: Cell Death Dis. 2022 Mar; 13(3): 196.

PMCID:: PMC8481269

Abstract Article PDF–3.7M

Select item 846307116.

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

Luka Bacic, Guillaume Gaullier, Anton Sabantsev, Laura C Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halic, Graeme Hewitt, Simon J Boulton, Sebastian Deindl

eLife. 2021; 10: e71420. Published online 2021 Sep 6. doi: 10.7554/eLife.71420

PMCID:: PMC8463071

Abstract Article PDF–5.3M

Select item 843358517.

Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling

Soon-Keat Ooi, Shigeo Sato, Chieri Tomomori-Sato, Ying Zhang, Zhihui Wen, Charles A. S. Banks, Michael P. Washburn, Jay R. Unruh, Laurence Florens, Ronald C. Conaway, Joan W. Conaway

Proc Natl Acad Sci U S A. 2021 Sep 7; 118(36): e2107277118. Published online 2021 Aug 31. doi: 10.1073/pnas.2107277118

PMCID:: PMC8433585

Abstract Article PDF–905K

Select item 824941418.

Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome

Li Wang, Kangjing Chen, Zhucheng Chen

Nat Commun. 2021; 12: 4057. Published online 2021 Jul 1. doi: 10.1038/s41467-021-24320-4

PMCID:: PMC8249414

Abstract Article PDF–1.8M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 796928020.

The high expression of CHD1L and its clinical significance in human solid tumors: A meta-analysis

Long Zhang, Yufen Jiang, Panpan Jiao, Xiaohong Deng, Yuancai Xie

Medicine (Baltimore) 2021 Mar 12; 100(10): e24851. Published online 2021 Mar 12. doi: 10.1097/MD.0000000000024851

PMCID:: PMC7969280

Abstract Article PDF–833K

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